Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy

Antitumor effects of a selenium heteropoly complex in K562 cells

(2014) Yang Jun-Ying et al.   Pharmacological Reports

Anticancer Effects of Garlic and Garlic-derived Compounds for Breast Cancer Control

(2012) Airo Tsubura et al.   Anti-Cancer Agents in Medicinal Chemistry

p38MAPK and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y

(2012) Giuseppe Filomeni et al.   BIOCHEMICAL PHARMACOLOGY

Methylselenocysteine Treatment Leads to Diselenide Formation in Human Cancer Cells: Evidence from X-ray Absorption Spectroscopy Studies

(2012) Claire M. Weekley et al.   BIOCHEMISTRY

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Decreased Selenium-Binding Protein 1 Enhances Glutathione Peroxidase 1 Activity and Downregulates HIF-1  to Promote Hepatocellular Carcinoma Invasiveness

(2012) C. Huang et al.   CLINICAL CANCER RESEARCH

The Quinoline Imidoselenocarbamate EI201 Blocks the AKT/mTOR Pathway and Targets Cancer Stem Cells Leading to a Strong Antitumor Activity

(2012) E. Ibanez et al.   CURRENT MEDICINAL CHEMISTRY

2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies

(2012) Kamaljit Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells

(2012) Patience Cole-Ezea et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural Features of Caspase-Activating Complexes

(2012) Hyun Ho Park   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant activity of β-selenoamines and their capacity to mimic different enzymes

(2012) Alessandro de Souza Prestes et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in TC-1 tumor development

(2012) YONG-WAN KIM et al.   ONCOLOGY REPORTS

Methylseleninic Acid Enhances Paclitaxel Efficacy for the Treatment of Triple-Negative Breast Cancer

(2012) Yanfeng Qi et al.   PLoS One

Rational Incorporation of Selenium into Temozolomide Elicits Superior Antitumor Activity Associated with Both Apoptotic and Autophagic Cell Death

(2012) Yan Cheng et al.   PLoS One

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

(2012) N. Gammoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of oxidative stress by selenomethionine in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss)

(2012) Sougat Misra et al.   TOXICOLOGY IN VITRO

Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad

(2011) Shutao Yin et al.   APOPTOSIS

5-Phenylselenyl- and 5-methylselenyl-methyl-2′-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells

(2011) Byeong Mo Kim et al.   APOPTOSIS

Delayed cell cycle progression from SEPW1 depletion is p53- and p21-dependent in MCF-7 breast cancer cells

(2011) Wayne Chris Hawkes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate cancer cell line

(2011) Mariana Freitas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p38 mitogen-activated protein kinase is a key regulator of 5-phenylselenyl- and 5-methylselenyl-methyl-2′-deoxyuridine-induced apoptosis in human HL-60 cells

(2011) Byeong Mo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis

(2011) Ling Kong et al.   BIOMATERIALS

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

(2011) Gowdahalli Krishnegowda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

P53 transcription-independent activity mediates selenite-induced acute promyelocytic leukemia NB4 cell apoptosis

(2011) Liying Guan et al.   BMB Reports

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

(2011) Yun Ren et al.   BMB Reports

Augmented therapeutic efficacy of irinotecan is associated with enhanced drug accumulation

(2011) Rami G. Azrak et al.   CANCER LETTERS

Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis

(2011) Hui Luo et al.   CANCER LETTERS

Melanoma Prevention Using Topical PBISe

(2011) C.-Y. Chung et al.   Cancer Prevention Research

Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply

(2011) Susanne Krehl et al.   CARCINOGENESIS

Susceptibility of the Antioxidant Selenoenyzmes Thioredoxin Reductase and Glutathione Peroxidase to Alkylation-Mediated Inhibition by Anticancer Acylfulvenes

(2011) Xiaodan Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model

(2011) A. K. Sharma et al.   CLINICAL CANCER RESEARCH

Kinase Regulation by Sulfur and Selenium Containing Compounds

(2011) C. Sanmartin et al.   CURRENT CANCER DRUG TARGETS

Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer

(2011) Alberto J. Montero et al.   DRUGS

Seleno-cyclodextrin sensitises human breast cancer cells to TRAIL-induced apoptosis through DR5 induction and NF-κB suppression

(2011) Tingting Lin et al.   EUROPEAN JOURNAL OF CANCER

Non-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathway

(2011) Tatjana Srdić-Rajić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent

(2011) Lihui Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagic and Apoptotic Effects of HDAC Inhibitors on Cancer Cells

(2011) Hidemi Rikiishi   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid

(2011) Chengfei Liu et al.   MOLECULAR CARCINOGENESIS

Novel Library of Selenocompounds as Kinase Modulators

(2011) Daniel Plano et al.   MOLECULES

Helichrysum gymnocephalum Essential Oil: Chemical Composition and Cytotoxic, Antimalarial and Antioxidant Activities, Attribution of the Activity Origin by Correlations

(2011) Samia Afoulous et al.   MOLECULES

Methylselenol, a Selenium Metabolite, Plays Common and Different Roles in Cancerous Colon HCT116 Cell and Noncancerous NCM460 Colon Cell Proliferation

(2011) Huawei Zeng et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

A superoxide anion-scavenger, 1,3-selenazolidin-4-one suppresses serum deprivation-induced apoptosis in PC12 cells by activating MAP kinase

(2011) Atsuyoshi Nishina et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selenium: a double-edged sword for defense and offence in cancer

(2010) Jela Brozmanová et al.   ARCHIVES OF TOXICOLOGY

Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction

(2010) Robyn L. Poerschke et al.   BIOCHEMICAL PHARMACOLOGY

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

(2010) Nilkamal Karelia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells

(2010) Maiko Suzuki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Melanoma Chemoprevention in Skin Reconstructs and Mouse Xenografts Using Isoselenocyanate-4

(2010) N. Nguyen et al.   Cancer Prevention Research

1,4-Phenylenebis(Methylene)Selenocyanate, but Not Selenomethionine, Inhibits Androgen Receptor and Akt Signaling in Human Prostate Cancer Cells

(2010) N. D. Facompre et al.   Cancer Prevention Research

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

(2010) Ria R. Ramoutar et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Selenium- and Tellurium-Containing Multifunctional Redox Agents as Biochemical Redox Modulators with Selective Cytotoxicity

(2010) Vincent Jamier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Persistent P21Cip1 Induction Mediates G1 Cell Cycle Arrest by Methylseleninic Acid in DU145 Prostate Cancer Cells

(2010) Z. Wang et al.   CURRENT CANCER DRUG TARGETS

Selenium Compounds Activate Early Barriers of Tumorigenesis

(2010) Min Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide

(2010) Snežana Bjelogrlić et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Genistein-Selenium Combination Induces Growth Arrest in Prostate Cancer Cells

(2010) James Kumi-Diaka et al.   JOURNAL OF MEDICINAL FOOD

Antioxidant-Prooxidant Properties of a New Organoselenium Compound Library

(2010) Daniel Plano et al.   MOLECULES

Downregulation of Protein Kinase Cα Was Involved in Selenite-Induced Apoptosis of NB4 Cells

(2010) Zhu-shi Li et al.   ONCOLOGY RESEARCH

Antileishmanial activity of imidothiocarbamates and imidoselenocarbamates

(2010) David Moreno et al.   PARASITOLOGY RESEARCH

SECIS-Binding Protein 2 Promotes Cell Survival by Protecting Against Oxidative Stress

(2009) Laura V. Papp et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

(2009) Markus Selenius et al.   ANTIOXIDANTS & REDOX SIGNALING

In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: a review

(2009) Vanessa Valdiglesias et al.   ARCHIVES OF TOXICOLOGY

SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors

(2009) Dhimant Desai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells

(2009) Rizky Abdulah et al.   BMC CANCER

Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate

(2009) Pramita Chakraborty et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Differential apoptotic response of human cancer cells to organoselenium compounds

(2009) Maiko Suzuki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The selenium analog of the chemopreventive compound S,S′-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer

(2009) Arunangshu Das et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In vivo radioprotection studies of 3,3′-diselenodipropionic acid, a selenocystine derivative

(2009) Amit Kunwar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of β-catenin signaling

(2009) Wenfeng Fang et al.   INTERNATIONAL JOURNAL OF CANCER

Preparation, Characterization, and Antiproliferative Activities of the Se-Containing Polysaccharide SeGLP-2B-1 from Se-Enriched Ganoderma lucidum

(2009) Dejing Shang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Methylselenol, a Selenium Metabolite, Induces Cell Cycle Arrest in G1 Phase and Apoptosis via the Extracellular-Regulated Kinase 1/2 Pathway and Other Cancer Signaling Genes

(2009) Huawei Zeng et al.   JOURNAL OF NUTRITION

Apoptosis induced by modulation in selenium status involves p38 MAPK and ROS: implications in spermatogenesis

(2009) Pavitra Ranawat et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis

(2009) Huawei Zeng   MOLECULES

Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity

(2009) Matthew Honeggar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selenite causes cytotoxicity in rainbow trout (Oncorhynchus mykiss) hepatocytes by inducing oxidative stress

(2009) Sougat Misra et al.   TOXICOLOGY IN VITRO

Diet, Autophagy, and Cancer: A Review

(2008) K. Singletary et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation

(2008) Tianfeng Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Antitumor effects of a novel sulfur-containing hydroxamate histone deacetylase inhibitor H40

(2008) Juan Long et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

(2008) Scott M. Lippman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Locally Generated Methylseleninic Acid Induces Specific Inactivation of Protein Kinase C Isoenzymes

(2008) Usha Gundimeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoproteins

(2008) Jun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metals and apoptosis: Recent developments

(2008) Suresh Vir Singh Rana   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Selenium Compounds and Apoptotic Modulation: A New Perspective in Cancer Therapy

(2008) Carmen Sanmartin et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis in breast cancer cells

(2008) Z. Li et al.   MOLECULAR CANCER THERAPEUTICS

The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo

(2008) Fengxia Xing et al.   ORAL ONCOLOGY

Selenium in food and the human body: A review

(2008) Miguel Navarro-Alarcon et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion

(2007) Huawei Zeng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY