Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors

Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs—A Promising Approach to Fight Cancer Drug Resistance

(2019) Gabriella Spengler et al.   MOLECULES

NCp7: targeting a multitask protein for next-generation anti-HIV drug development part 2. Noncovalent inhibitors and nucleic acid binders

(2018) Nunzio Iraci et al.   DRUG DISCOVERY TODAY

NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors

(2018) Luca Sancineto et al.   DRUG DISCOVERY TODAY

Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

(2018) Valentina Gandin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aglycone Ebselen and β-d-Xyloside Primed Glycosaminoglycans Co-contribute to Ebselen β-d-Xyloside-Induced Cytotoxicity

(2018) Yang Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents

(2018) Baijiao An et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity

(2018) Mónica Álvarez-Pérez et al.   MOLECULES

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells

(2018) Yuko Shishido et al.   CHEMBIOCHEM

Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity

(2018) Zhao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents

(2017) Yanqing Pang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selenopheno quinolinones and coumarins promote cancer cell apoptosis by ROS depletion and caspase-7 activation

(2017) Ilona Domracheva et al.   LIFE SCIENCES

Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors

(2017) Andrea Angeli et al.   ACS Medicinal Chemistry Letters

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Identification of selenocompounds with promising properties to reverse cancer multidrug resistance

(2016) Enrique Domínguez-Álvarez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural and Biochemical Analyses Reveal the Mechanism of GlutathioneS-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

(2016) Wayne Harshbarger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

(2016) Daniel Plano et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors

(2016) Katarzyna Macegoniuk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selenium potentiates the anticancer effect of cisplatin against oxidative stress and calcium ion signaling-induced intracellular toxicity in MCF-7 breast cancer cells: involvement of the TRPV1 channel

(2016) Esin Sakallı Çetin et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress

(2016) Chaoran Dong et al.   Scientific Reports

World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015

(2016) Shelley McGuire   Advances in Nutrition

Molecular Mechanism Behind the Synergistic Activity of Diphenylmethyl Selenocyanate and Cisplatin Against Murine Tumor Model

(2015) Pramita Chakraborty et al.   Anti-Cancer Agents in Medicinal Chemistry

Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides

(2015) D. Bartolini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy

(2015) Inês L. Martins et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives

(2015) Diego de Souza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity

(2015) Luca Sancineto et al.   JOURNAL OF MEDICINAL CHEMISTRY

p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening

(2015) Andrea Astolfi et al.   MOLECULES

Redox-Active Selenium Compounds—From Toxicity and Cell Death to Cancer Treatment

(2015) Sougat Misra et al.   Nutrients

Synthesis of new diorganodiselenides from organic halides: their antiproliferative effects against human breast cancer MCF-7 cells

(2014) Chaewon Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides

(2014) Masood Ahmad Rizvi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of new nitrogen-containing diselenides

(2014) Vanessa Nascimento et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic analysis of ammonium cation stability for alkaline exchange membrane fuel cells

(2014) Angela D. Mohanty et al.   Journal of Materials Chemistry A

The early research and development of ebselen

(2013) Michael J. Parnham et al.   BIOCHEMICAL PHARMACOLOGY

Computer-Aided Design, Synthesis and Validation of 2-Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity

(2013) Luca Sancineto et al.   ChemMedChem

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Synthesis and Structure of Organobismuth Chlorides and Triflates Containing (C,E)-Chelating Ligands (E=O, S) and Their Catalytic Application in the Allylation of Aldehydes with Tetraallyltin

(2013) Nianyuan Tan et al.   ChemPlusChem

Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent

(2011) Lihui Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione transferases and development of new principles to overcome drug resistance

(2010) Andrea Sau et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Organoselenium Chemistry: Role of Intramolecular Interactions†

(2010) Anna J. Mukherjee et al.   CHEMICAL REVIEWS

Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases

(2009) L. Federici et al.   CANCER RESEARCH

Synthesis and Structure-Activity Correlation Studies of Secondary- and Tertiary-Amine-Based Glutathione Peroxidase Mimics

(2009) Krishna P. Bhabak et al.   CHEMISTRY-A EUROPEAN JOURNAL

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Tumor Vascular Maturation and Improved Drug Delivery Induced by Methylselenocysteine Leads to Therapeutic Synergy with Anticancer Drugs

(2008) A. Bhattacharya et al.   CLINICAL CANCER RESEARCH

The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants

(2008) Lorien J. Parker et al.   JOURNAL OF MOLECULAR BIOLOGY