标题
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance
作者
关键词
-
出版物
Cells
Volume 9, Issue 12, Pages 2598
出版商
MDPI AG
发表日期
2020-12-05
DOI
10.3390/cells9122598
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
- (2020) Russel J. Reiter et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
- (2020) Cyril Corbet et al. Nature Communications
- Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK
- (2020) Nurbubu T. Moldogazieva et al. Cancers
- Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy
- (2020) Alexander Kabakov et al. Cells
- 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells
- (2020) Xiaodong Sun et al. BIOCHEMICAL PHARMACOLOGY
- Energy metabolism in cancer stem cells
- (2020) Xuan Zhu et al. World Journal of Stem Cells
- Lactate Exposure Promotes Immunosuppressive Phenotypes in Innate Immune Cells
- (2020) Rapeepat Sangsuwan et al. Cellular and Molecular Bioengineering
- Integrative Analysis of Hypoxia-Associated Signature in Pan-Cancer
- (2020) Qian Zhang et al. iScience
- Pharmacologic Targeting of Hypoxia-Inducible Factors
- (2019) Gregg L. Semenza Annual Review of Pharmacology and Toxicology
- Cancer Stem Cells: The Architects of the Tumor Ecosystem
- (2019) Briana C. Prager et al. Cell Stem Cell
- Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy
- (2019) Sheng Wang et al. Advanced Science
- HIF Inhibitors: Status of Current Clinical Development
- (2019) Jaleh Fallah et al. Current Oncology Reports
- Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma
- (2019) Prashant Mujumdar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lactate secreted by cervical cancer cells modulates macrophage phenotype
- (2019) Simone Cardozo Stone et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Causes, consequences, and therapy of tumors acidosis
- (2019) Smitha R. Pillai et al. CANCER AND METASTASIS REVIEWS
- Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation
- (2019) Nahyeon Kang et al. BMC CANCER
- The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy
- (2019) Najah Albadari et al. Expert Opinion on Drug Discovery
- Wnt/IL‐1β/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5
- (2019) Vladan Milosevic et al. INTERNATIONAL JOURNAL OF CANCER
- Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer
- (2019) Luigi Ippolito et al. ONCOGENE
- Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?
- (2019) Joanna Kopecka et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances
- (2019) Pouya Saraei et al. Cancer Management and Research
- HIF-1α is overexpressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia
- (2019) Valentina Griggio et al. HAEMATOLOGICA
- Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma
- (2019) Jinkyu Jung et al. CANCER RESEARCH
- What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg
- (2019) Teodora Alexa-Stratulat et al. DRUG RESISTANCE UPDATES
- p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer
- (2019) Chae Young Han et al. MOLECULAR CARCINOGENESIS
- Characterization of glycolysis-related gene expression in malignant melanoma
- (2019) Andreas Koch et al. PATHOLOGY RESEARCH AND PRACTICE
- Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
- (2019) Inês Godet et al. Nature Communications
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
- (2019) Karen G. de la Cruz-López et al. Frontiers in Oncology
- Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway
- (2019) David Kung-Chun Chiu et al. Cell Death & Disease
- miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target
- (2018) Marcin Serocki et al. ANGIOGENESIS
- Metabolic reprogramming in keloid fibroblasts: Aerobic glycolysis and a novel therapeutic strategy
- (2018) Qi Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma
- (2018) Ke Duan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
- (2018) Debangshu Samanta et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- The Science and Translation of Lactate Shuttle Theory
- (2018) George A. Brooks Cell Metabolism
- Including the mitochondrial metabolism of l-lactate in cancer metabolic reprogramming
- (2018) Lidia de Bari et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- An inhibitory antibody targeting Carbonic Anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo
- (2018) Bettina von Neubeck et al. INTERNATIONAL JOURNAL OF CANCER
- Hypoxia-induced autophagy promotes gemcitabine resistance in human bladder cancer cells through hypoxia-inducible factor 1α activation
- (2018) Xiaoyu Yang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- An inhibitor of oxidative phosphorylation exploits cancer vulnerability
- (2018) Jennifer R. Molina et al. NATURE MEDICINE
- Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer
- (2018) Yen-An Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
- (2018) Cyril Corbet et al. Nature Communications
- Propofol Reversed Hypoxia-Induced Docetaxel Resistance in Prostate Cancer Cells by Preventing Epithelial–Mesenchymal Transition by Inhibiting Hypoxia-Inducible Factor 1α
- (2018) Jiang Qian et al. Biomed Research International
- MCT1 regulates aggressive and metabolic phenotypes in bladder cancer
- (2018) Guiming Zhang et al. Journal of Cancer
- Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells
- (2018) Elena Gazzano et al. Frontiers in Pharmacology
- Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers
- (2018) Aziz Aiderus et al. BMC CANCER
- Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers
- (2018) Susmita Mondal et al. INTERNATIONAL JOURNAL OF CANCER
- Carbonic anhydrase XII inhibitors overcome P-glycoprotein-mediated resistance to temozolomide in glioblastoma
- (2018) Iris C. Salaroglio et al. MOLECULAR CANCER THERAPEUTICS
- Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
- (2018) Giovanna Butera et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Role of HIF-1 in Cancer Progression: Novel Insights. A Review
- (2018) Aldo Pezzuto et al. CURRENT MOLECULAR MEDICINE
- Pyruvate Treatment Restores the Effectiveness of Chemotherapeutic Agents in Human Colon Adenocarcinoma and Pleural Mesothelioma Cells
- (2018) Eleonora Mungo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer
- (2018) Iris C. Salaroglio et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin
- (2018) Miao He et al. Molecular Oncology
- Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
- (2018) Fengming Lin et al. MOLECULES
- New horizons in hypoxia signaling pathways
- (2017) Christopher W. Pugh et al. EXPERIMENTAL CELL RESEARCH
- Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A “structure-activity relationship” perspective
- (2017) Deepak Bhattarai et al. MEDICINAL RESEARCH REVIEWS
- PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy
- (2017) Iris C. Salaroglio et al. Molecular Cancer
- Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
- (2017) Lindsay Wilde et al. SEMINARS IN ONCOLOGY
- HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
- (2017) Weinan Du et al. Nature Communications
- VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
- (2017) Xiaosai Yao et al. Cancer Discovery
- Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms
- (2017) Balaraman Kalyanaraman et al. Interface Focus
- Fatty acid metabolism in breast cancer subtypes
- (2017) Marie E. Monaco Oncotarget
- Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression
- (2017) Ayano Kondo et al. Cell Reports
- The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction
- (2017) Giulia Cheloni et al. Stem Cells International
- The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
- (2017) Chang Dong Yeo et al. KOREAN JOURNAL OF INTERNAL MEDICINE
- Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells
- (2017) F Pepe et al. Oncogenesis
- HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death
- (2017) Akihisa Okamoto et al. Scientific Reports
- Hypoxia-inducible factor 3 biology: complexities and emerging themes
- (2016) Cunming Duan AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
- (2016) Johann Matschke et al. ANTIOXIDANTS & REDOX SIGNALING
- Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells
- (2016) Baoqing Guo et al. BMC CANCER
- Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis
- (2016) Marco Cordani et al. CANCER LETTERS
- Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect
- (2016) Iñigo San-Millán et al. CARCINOGENESIS
- Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation
- (2016) Cyril Corbet et al. Cell Metabolism
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Molecular mechanisms for tumour resistance to chemotherapy
- (2016) Shu-Ting Pan et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition
- (2016) Jessica Brandi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Integration of superoxide formation and cristae morphology for mitochondrial redox signaling
- (2016) Lydie Plecitá-Hlavatá et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export
- (2016) Scott K. Parks et al. MOLECULAR ASPECTS OF MEDICINE
- Lactate metabolism is associated with mammalian mitochondria
- (2016) Ying-Jr Chen et al. Nature Chemical Biology
- Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
- (2016) Edoardo Gaude et al. Nature Communications
- P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
- (2016) Joanna Kopecka et al. Oncotarget
- Emetine induces chemosensitivity and reduces clonogenicity of acute myeloid leukemia cells
- (2016) Josep Maria Cornet-Masana et al. Oncotarget
- Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
- (2016) Laura Pisarsky et al. Cell Reports
- Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions
- (2016) Gaspard Cretenet et al. Scientific Reports
- Common Responses of Tumors and Wounds to Hypoxia
- (2015) Valéry L. Payen et al. CANCER JOURNAL
- Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein
- (2015) Chiara Riganti et al. CANCER LETTERS
- Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism
- (2015) Gang Cheng et al. CANCER LETTERS
- Tumors and Mitochondrial Respiration: A Neglected Connection
- (2015) Andrea Viale et al. CANCER RESEARCH
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
- (2015) An S. Tan et al. Cell Metabolism
- Sugar, fat, and protein: new insights into what T cells crave
- (2015) Greg M Delgoffe et al. CURRENT OPINION IN IMMUNOLOGY
- The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells
- (2015) Yun Shen et al. EXPERIMENTAL CELL RESEARCH
- HIF3α: the little we know
- (2015) Linda Ravenna et al. FEBS Journal
- HIF-1 at the crossroads of hypoxia, inflammation, and cancer
- (2015) Kuppusamy Balamurugan INTERNATIONAL JOURNAL OF CANCER
- Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
- (2015) Ibtissam Marchiq et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Emerging roles of hypoxia-inducible factors and reactive oxygen species in cancer and pluripotent stem cells
- (2015) Shigeo Saito et al. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
- Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)
- (2015) SHENG-LI YANG et al. Molecular Medicine Reports
- Nutrient-sensing mechanisms and pathways
- (2015) Alejo Efeyan et al. NATURE
- Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
- (2015) Haiquan Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC, Metabolism, and Cancer
- (2015) Z. E. Stine et al. Cancer Discovery
- Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells
- (2015) Joanna Kopecka et al. Oncotarget
- Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
- (2015) Micol Rigoni et al. Oncotarget
- Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells
- (2015) Joanna Kopecka et al. Oncotarget
- Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
- (2015) Mauricio Reginato et al. Cancer Management and Research
- 2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells
- (2015) Shuo-Yu Wang et al. PLoS One
- Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma
- (2015) Iris Chiara Salaroglio et al. Oncotarget
- Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate
- (2014) Rakesh K. Pathak et al. ACS Chemical Biology
- Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
- (2014) S R McKeown BRITISH JOURNAL OF RADIOLOGY
- The SIRT1/HIF2 Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
- (2014) C. Corbet et al. CANCER RESEARCH
- The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy
- (2014) Elisabetta Rovida et al. CELL CYCLE
- The anti-androgen drug dutasteride renders triple negative breast cancer cells more sensitive to chemotherapy via inhibition of HIF-1α-/VEGF-signaling
- (2014) Marie-Kristin von Wahlde et al. GYNECOLOGICAL ENDOCRINOLOGY
- The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I
- (2014) Casey L. Quinlan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress
- (2014) Apolinar Maya-Mendoza et al. Molecular Oncology
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- (2014) Valerie S. LeBleu et al. NATURE CELL BIOLOGY
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Tanshinone IIA blocks epithelial-mesenchymal transition through HIF-1α downregulation, reversing hypoxia-induced chemotherapy resistance in breast cancer cell lines
- (2014) PEIFEN FU et al. ONCOLOGY REPORTS
- Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities
- (2014) María Cristina Estañ et al. PLoS One
- Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia
- (2014) Catherine J. Kelly et al. RADIOTHERAPY AND ONCOLOGY
- Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival
- (2014) Mireille Khacho et al. Nature Communications
- Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia
- (2014) J. Ye et al. Cancer Discovery
- HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
- (2014) De Huang et al. Cell Reports
- Hypoxia-regulated microRNAs in human cancer
- (2013) Guomin Shen et al. ACTA PHARMACOLOGICA SINICA
- Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype
- (2013) Shiva Kant et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids
- (2013) Sharon M. Louie et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Epithelial–mesenchymal transition and cancer stemness: the Twist1–Bmi1 connection
- (2013) Kou‑Juey Wu et al. BIOSCIENCE REPORTS
- Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma
- (2013) Hironori Betsunoh et al. BMC CANCER
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
- (2013) Peter J. Ratcliffe JOURNAL OF PHYSIOLOGY-LONDON
- The SLC3 and SLC7 families of amino acid transporters
- (2013) Dimitrios Fotiadis et al. MOLECULAR ASPECTS OF MEDICINE
- Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/ -catenin pathway
- (2013) C. Riganti et al. NEURO-ONCOLOGY
- Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation
- (2013) Ajay Kumar et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Nutrient transporters: the Achilles’ heel of anabolism
- (2013) Alison N. McCracken et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Expression and significance of hypoxia-inducible factor-1α and MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2 cells
- (2013) JIN XIE et al. Oncology Letters
- BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I
- (2013) Peter Ellinghaus et al. Cancer Medicine
- Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
- (2013) Zaheed Husain et al. OncoImmunology
- Expression of glucose transporters in cancers
- (2012) Leszek Szablewski BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast
- (2012) Sophie Doublier et al. BMC CANCER
- Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
- (2012) Ralph J. DeBerardinis et al. CELL
- The extracellular matrix: A dynamic niche in cancer progression
- (2012) Pengfei Lu et al. JOURNAL OF CELL BIOLOGY
- Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
- (2012) I. Mylonis et al. JOURNAL OF CELL SCIENCE
- HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5
- (2012) Ainara Elorza et al. MOLECULAR CELL
- Physiological Roles of Mitochondrial Reactive Oxygen Species
- (2012) Laura A. Sena et al. MOLECULAR CELL
- PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations
- (2012) Z Yao et al. ONCOGENE
- BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery
- (2012) J Hagenbuchner et al. ONCOGENE
- The VHL/HIF axis in clear cell renal carcinoma
- (2012) Chuan Shen et al. SEMINARS IN CANCER BIOLOGY
- Acute versus chronic hypoxia in tumors
- (2012) C. Bayer et al. STRAHLENTHERAPIE UND ONKOLOGIE
- Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
- (2012) Gregg L. Semenza TRENDS IN PHARMACOLOGICAL SCIENCES
- The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
- (2011) Marcus Conrad et al. AMINO ACIDS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
- (2011) Nadine Rohwer et al. DRUG RESISTANCE UPDATES
- Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
- (2011) K. Zaugg et al. GENES & DEVELOPMENT
- Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
- (2011) Aude Carreau et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
- (2011) R. D. Michalek et al. JOURNAL OF IMMUNOLOGY
- Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers
- (2011) Man Yu LIFE SCIENCES
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Invited review: decoding the microRNA response to hypoxia
- (2011) Roger Pocock PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Regulation of vitamin metabolism by p53 and p63 in development and cancer
- (2010) Huiqing Zhou et al. CELL CYCLE
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB
- (2010) Nadine Rohwer et al. PLoS One
- Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
- (2010) F. Weinberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quiescent Fibroblasts Exhibit High Metabolic Activity
- (2010) Johanna M. S. Lemons et al. PLOS BIOLOGY
- Tumor Angiogenesis: Insights and Innovations
- (2010) Fernando Nussenbaum et al. Journal of Oncology
- Suppression of Hypoxia-Inducible Factor 2 Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells
- (2009) A. M. Roberts et al. CANCER RESEARCH
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- HIF-1: upstream and downstream of cancer metabolism
- (2009) Gregg L Semenza CURRENT OPINION IN GENETICS & DEVELOPMENT
- Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1
- (2009) R. Sullivan et al. MOLECULAR CANCER THERAPEUTICS
- Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
- (2009) R J DeBerardinis et al. ONCOGENE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- P-Glycoprotein Senses Its Substrates and the Lateral Membrane Packing Density: Consequences for the Catalytic Cycle†
- (2008) Päivi Äänismaa et al. BIOCHEMISTRY
- Tumor Cell Metabolism: Cancer's Achilles' Heel
- (2008) Guido Kroemer et al. CANCER CELL
- Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1
- (2008) E. Furuta et al. CANCER RESEARCH
- Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH
- (2008) J. Chiche et al. CANCER RESEARCH
- Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 -deficient mouse embryonic fibroblasts
- (2008) R. Wirthner et al. CARCINOGENESIS
- Role and regulation of prolyl hydroxylase domain proteins
- (2008) G-H Fong et al. CELL DEATH AND DIFFERENTIATION
- Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes
- (2008) Manlio Vinciguerra et al. HEPATOLOGY
- Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance
- (2008) Lili Liu et al. INTERNATIONAL JOURNAL OF CANCER
- Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
- (2008) Huafeng Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
- Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2
- (2008) Fusun Baumann et al. NEURO-ONCOLOGY
- Effect of Hypoxia-inducible Factor-1α Silencing on the Sensitivity of Human Brain Glioma Cells to Doxorubicin and Etoposide
- (2008) Lei Chen et al. NEUROCHEMICAL RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search