Article
Biochemistry & Molecular Biology
Sho Koyasu, Shoichiro Horita, Keisuke Saito, Minoru Kobayashi, Hiroshi Ishikita, Christalle C. T. Chow, Gouki Kambe, Shigeto Nishikawa, Toshi Menju, Akiyo Morinibu, Yasushi Okochi, Yoshiaki Tabuchi, Yasuhito Onodera, Norihiko Takeda, Hiroshi Date, Gregg L. Semenza, Ester M. Hammond, Hiroshi Harada
Summary: p53 deficiency triggers the activation of HIF-1 and ZBTB2 plays a crucial role in this process. ZBTB2 promotes invasion and growth of p53-deficient cancers and is associated with poor prognosis in lung cancer patients. ZBTB2 N-terminus-mimetic polypeptides inhibit ZBTB2 activity and suppress tumor aggressiveness.
Article
Medicine, Research & Experimental
Jingyao Yang, Long Li, Xiaoxiao Zheng, Zhaoyang Lu, Hua Zhou
Summary: As a sodium-glucose transporter 2 inhibitor (SGLT2i), Dapagliflozin (DAPA) has been widely recognized for its cardioprotective benefits. This study explored the underlying mechanisms of DAPA on angiotensin II (Ang II)-induced myocardial hypertrophy and found that DAPA treatment can alleviate Ang II-induced cardiac injury, hypertrophy, and fibrosis. It also reversed the changes in HIF-1a and SIRT1 levels induced by Ang II. Overall, activating the SIRT1/HIF-1a signaling pathway may be an effective therapeutic target for pathological cardiac hypertrophy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Hui Wang, Runling Ren, Zizhong Yang, Jun Cai, Shaoxia Du, Xiaohong Shen
Summary: COL11A1 modulates apoptotic inhibition and chemoresistance in pancreatic cancer cells by activating the Akt/CREB/BCL-2/BAX signaling pathway, suggesting it may serve as a distinct prognostic indicator and an attractive therapeutic target for PDAC.
Article
Biochemistry & Molecular Biology
Jungwhoi Lee, Eunsoo Kim, Kyuha Chong, Seung-Wook Ryu, Chungyeul Kim, Kyungsun Choi, Jae-Hoon Kim, Chulhee Choi
Summary: Contact-based pericellular interactions play an important role in cancer progression, specifically in glioblastoma multiforme (GBM) cells through Notch1 signaling and HIF-1 alpha expression. Inhibiting Notch1 signaling and HIF pathway can lead to reduced tumor development and increased sensitivity to treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Jing-Hua Liu, Wen-Ting Li, Yue Yang, Yan-Bo Qi, Yu Cheng, Jia-Hui Wu
Summary: The study revealed that miR-526b-3p plays a crucial role in regulating breast cancer stem cell properties and chemoresistance by targeting the HIF-miR-526b-3p/Notch signaling pathway. This suggests that miR-526b-3p may be a potential therapeutic target for overcoming chemoresistance in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis
Summary: ERK-mediated phosphorylation of HIF-1 alpha enhances its interaction with NPM1, which influences the transcriptional activation of HIF-1 target genes. NPM1 and HIF-1 co-regulate genes enriched in different cancer types, and their expression correlates with hypoxic tumor status and patient prognosis.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Feikai Lin, Xiaoduan Li, Xinjing Wang, Huizhen Sun, Ziliang Wang, Xipeng Wang
Summary: This study found that STC1 is significantly enhanced in ovarian cancer tissues, especially in peritoneal metastasis tissues. STC1 promotes metastasis, lipid metabolism, and cisplatin chemoresistance in ovarian cancer through the FOXC2/ITGB6 signaling pathway. Therefore, STC1 may serve as a prognostic indicator for metastatic ovarian cancer and a potential therapeutic target for patients with cisplatin resistance.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Min Yin, Chunli Lu, Huimei Zhou, Qian Liu, Jiaxin Yang
Summary: While the pathogenesis of ovarian clear cell carcinoma (OCCC) has been widely studied, the mechanism of chemoresistance remains unknown. This study identified fibroblast growth factor 11 (FGF11) as a key gene associated with platinum resistance in OCCC tissues. Inhibition of FGF11 reversed the resistance to cisplatin and suppressed the progression of OCCC. Mechanistically, FGF11 expression was regulated by hypoxia-inducible factor-1α (HIF-1α) to modulate cisplatin sensitivity.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Lu Yu, Wei Li
Summary: The Notch1 signaling pathway is upregulated in cervical cancer and its depletion leads to apoptotic cell death and increased sensitivity to DNA-targeting drugs, suggesting its essential role in cervical cancer progression and apoptosis resistance.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Po-Li Wei, Chien-Yu Huang, Tung-Cheng Chang, Jang-Chun Lin, Cheng-Chin Lee, G. M. Shazzad Hossain Prince, Precious Takondwa Makondi, Angelina Wong-Ying Chui, Yu-Jia Chang
Summary: Colorectal cancer is a common and lethal type of cancer, and finding effective treatments for it is urgently needed. This study revealed that PCTK1 can suppress the proliferation and cancer stemness of colorectal cancer by regulating the BMPR1B-Smad1/5/8 signaling pathway, and enhance its response to chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Hao Wu, Yijun Chu, Shanshan Sun, Guozheng Li, Shouping Xu, Xianyu Zhang, Yongdong Jiang, Song Gao, Qin Wang, Jian Zhang, Da Pang
Summary: This study found that hypoxia-induced HIF-1 alpha upregulated C1QBP, which when inhibited, notably blocked the metastasis of TNBC cells and increased their sensitivity to PTX under hypoxic conditions. Depletion of C1QBP decreased VCAM-1 expression by reducing the amount of P65 in the nucleus and suppressed the activation of hypoxia-induced PKC-NF-kappa B signaling. Targeting C1QBP along with PTX treatment could be a potential treatment for TNBC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhiguo Niu, Jianing Fan, Fengzhe Chen, Huijie Yang, Xin Li, Ting Zhuang, Chunlei Guo, Qi Cao, Jian Zhu, Hui Wang, Qingsong Huang
Summary: Breast cancer is the most common malignancy in women globally. Abnormal expression of RBCK1 protein in breast tumors makes it a valuable diagnostic marker and drug target. Hypoxic regions in breast cancer activate the HIF1 pathway, influencing tumor recurrence and metastasis. Targeting RBCK1 could be a promising treatment strategy for ER-positive breast cancer.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jing Zhou, Yang Lin, Xiuhua Kang, Zhicheng Liu, Juntao Zou, Fei Xu
Summary: This study reveals the role of FBXL7 in NSCLC and its upstream and downstream mechanisms. FBXL7 is downregulated in NSCLC and degrades PFKFB4, inhibiting glucose metabolism and malignant phenotypes. The EZH2/FBXL7/PFKFB4 axis plays a regulatory role in glucose metabolism and tumor growth of NSCLC.
CELL DEATH & DISEASE
(2023)
Review
Medicine, Research & Experimental
Ana R. Costa, Ana C. Duarte, Ana R. Costa-Brito, Isabel Goncalves, Cecilia R. A. Santos
Summary: Pharmacoresistance of cancer cells to chemotherapy drugs is a major challenge. ABC transporters are a leading cause of drug resistance as they transport drugs out of the cells. TAS2Rs, regulated by bitter taste receptors, have been found in various cancer types and organs, and their activation has been linked to multiple biological actions. Bitter compounds, such as flavonoids and alkaloids, have shown potential as adjuvants in cancer therapy. This review discusses the therapeutic role of TAS2Rs and bitter compounds in overcoming chemoresistance in different types of cancer.
Review
Oncology
Yukari Shirai, Christalle C. T. Chow, Gouki Kambe, Tatsuya Suwa, Minoru Kobayashi, Itsuki Takahashi, Hiroshi Harada, Jin-Min Nam
Summary: HIF-1 is a critical target for cancer therapy due to its association with hypoxia, malignant phenotype, and therapy resistance in tumors. Recent research has focused on uncovering the molecular mechanisms of HIF-1 activation, identifying HIF-1 activators, and developing anticancer drugs targeting HIF-1.
