The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction

ANN Prediction of Metabolic Syndrome: a Complex Puzzle that will be Completed

(2016) Darko Ivanović et al.   JOURNAL OF MEDICAL SYSTEMS

Different BCR/Abl protein suppression patterns as a converging trait of chronic myeloid leukemia cell adaptation to energy restriction

(2016) Silvia Bono et al.   Oncotarget

The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo

(2015) Hal E. Broxmeyer et al.   CURRENT OPINION IN HEMATOLOGY

The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapy

(2014) Elisabetta Rovida et al.   CELL CYCLE

CD63 Tetraspanin Is a Negative Driver of Epithelial-to-Mesenchymal Transition in Human Melanoma Cells

(2014) Antonella Lupia et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

(2013) B. Li et al.   CLINICAL CANCER RESEARCH

AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia

(2013) V Barbetti et al.   Cell Death & Disease

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

Selection pressure exerted by imatinib therapy leads to disparate outcomes of imatinib discontinuation trials

(2012) M. Tang et al.   HAEMATOLOGICA

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

(2011) A. Hamilton et al.   BLOOD

Combination of low O2concentration and mesenchymal stromal cells during culture of cord blood CD34+cells improves the maintenance and proliferative capacity of hematopoietic stem cells

(2011) Mohammad Hammoud et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exploiting the balance between life and death: Targeted cancer therapy and “oncogenic shock”

(2010) Sreenath V. Sharma et al.   BIOCHEMICAL PHARMACOLOGY

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen

(2010) Amélie V. Guitart et al.   EXPERIMENTAL HEMATOLOGY

Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate

(2010) S. Giuntoli et al.   HAEMATOLOGICA

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia or in situ normoxia: The stem cell paradigm

(2009) Zoran Ivanovic   JOURNAL OF CELLULAR PHYSIOLOGY