Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

The evolving use of arsenic in pharmacotherapy of malignant disease

(2013) Athena Kritharis et al.   ANNALS OF HEMATOLOGY

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

(2013) Haibin Xi et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells

(2013) S Scotland et al.   LEUKEMIA

Growth of xenotransplanted leukemia cells is influenced by diet nutrients and is attenuated with 2-deoxyglucose

(2013) Norikazu Tsunekawa-Imai et al.   LEUKEMIA RESEARCH

Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel

(2013) Jiajin Li et al.   PLoS One

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

2-Deoxy-d-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: Involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways

(2012) María Cristina Estañ et al.   BIOCHEMICAL PHARMACOLOGY

Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease

(2012) Massimo Breccia et al.   EXPERT OPINION ON PHARMACOTHERAPY

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

(2012) Y. H. Ko et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Inhibition of Fatty Acid Metabolism Reduces Human Myeloma Cells Proliferation

(2012) José Manuel Tirado-Vélez et al.   PLoS One

Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation

(2011) Eva Calviño et al.   BIOCHEMICAL PHARMACOLOGY

AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia

(2011) J. N. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Curcumin Stimulates Reactive Oxygen Species Production and Potentiates Apoptosis Induction by the Antitumor Drugs Arsenic Trioxide and Lonidamine in Human Myeloid Leukemia Cell Lines

(2010) Y. Sanchez et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Energy metabolism of leukemia cells: glycolysisversusoxidative phosphorylation

(2010) Kazuto Suganuma et al.   LEUKEMIA & LYMPHOMA

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy

(2009) BS Dwarakanath et al.   Future Oncology

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir

(2008) Emma Hernlund et al.   INTERNATIONAL JOURNAL OF CANCER

Genistein selectively potentiates arsenic trioxide‐induced apoptosis in human leukemia cellsviareactive oxygen species generation and activation of reactive oxygen species‐inducible protein kinases (p38‐MAPK, AMPK)

(2008) Yolanda Sánchez et al.   INTERNATIONAL JOURNAL OF CANCER