Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Structural basis for pharmacological modulation of the TRPC6 channel

(2020) Yonghong Bai et al.   eLife

Irritant-evoked activation and calcium modulation of the TRPA1 receptor

(2020) Jianhua Zhao et al.   NATURE

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

(2019) Feng Zhang et al.   eLife

TRPC-mediated Ca2+ signaling and control of cellular functions

(2019) Sanja Curcic et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Protein Multiple Alignments: Sequence-based vs Structure-based Programs

(2019) Mathilde Carpentier et al.   BIOINFORMATICS

Structural insight into TRPV5 channel function and modulation

(2019) Shangyu Dang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

(2019) Lejla Zubcevic et al.   eLife

Regulatory switch at the cytoplasmic interface controls TRPV channel gating

(2019) Lejla Zubcevic et al.   eLife

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Opening TRPP2 (PKD2L1) requires the transfer of gating charges

(2019) Leo C. T. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

(2019) Jingjing Duan et al.   Science Advances

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

(2019) Yihe Huang et al.   eLife

Molecular mechanism of TRPV2 channel modulation by cannabidiol

(2019) Ruth A Pumroy et al.   eLife

The role of π-helices in TRP channel gating

(2019) Lejla Zubcevic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis of temperature sensation by the TRP channel TRPV3

(2019) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

(2019) Ying Yin et al.   Nature Communications

Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii

(2019) Luke L. McGoldrick et al.   Nature Communications

The ion selectivity filter is not an activation gate in TRPV1-3 channels

(2019) Andrés Jara-Oseguera et al.   eLife

Structure-based characterization of novel TRPV5 inhibitors

(2019) Taylor ET Hughes et al.   eLife

Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology

(2019) Xiao Tao et al.   eLife

Structural Basis of Human KCNQ1 Modulation and Gating

(2019) Ji Sun et al.   CELL

Molecular structures of the human Slo1 K+ channel in complex with β4

(2019) Xiao Tao et al.   eLife

TRP Channels as Potential Drug Targets

(2018) Magdalene M. Moran   Annual Review of Pharmacology and Toxicology

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

(2018) Qinglin Tang et al.   CELL RESEARCH

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational plasticity in the selectivity filter of the TRPV2 ion channel

(2018) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of full-length human TRPM4

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures

(2018) Chia-Hsueh Lee et al.   SCIENCE

Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

(2018) Qiang Su et al.   Nature Communications

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

(2018) Wang Zheng et al.   Nature Communications

Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

(2018) Appu K. Singh et al.   Nature Communications

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational plasticity in the selectivity filter of the TRPV2 ion channel

(2018) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

(2018) Deivanayagabarathy Vinayagam et al.   eLife

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

Cryo-EM structure of the polycystin 2-l1 ion channel

(2018) Raymond E Hulse et al.   eLife

Protein–Lipid Interfaces Can Drive the Functions of Membrane-Embedded Protein–Protein Complexes

(2018) Debayan Sarkar et al.   ACS Chemical Biology

Inhibitory effects of cannabidiol on voltage-dependent sodium currents

(2018) Mohammad-Reza Ghovanloo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

Structure and gating mechanism of the transient receptor potential channel TRPV3

(2018) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human PKD1-PKD2 complex

(2018) Qiang Su et al.   SCIENCE

Structure of the mouse TRPC4 ion channel

(2018) Jingjing Duan et al.   Nature Communications

Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6

(2018) Appu K. Singh et al.   Science Advances

A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine

(2018) Marina A. Kasimova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structures of TRPV2 in distinct conformations provide insight into role of the pore turret

(2018) Timothy L. Dosey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRPV1 pore turret dictates distinct DkTx and capsaicin gating

(2018) Matan Geron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures and gating mechanism of human TRPM2

(2018) Longfei Wang et al.   SCIENCE

Structural basis for PtdInsP2-mediated human TRPML1 regulation

(2018) Michael Fine et al.   Nature Communications

Conformational ensemble of the human TRPV3 ion channel

(2018) Lejla Zubcevic et al.   Nature Communications

Structural insights on TRPV5 gating by endogenous modulators

(2018) Taylor E. T. Hughes et al.   Nature Communications

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

(2017) Marscha Hirschi et al.   NATURE

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

(2017) Qingfeng Chen et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of a putative binding site critical for general anesthetic activation of TRPA1

(2017) Hoai T. Ton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

(2017) Appu K. Singh et al.   Scientific Reports

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

X-ray structures define human P2X3 receptor gating cycle and antagonist action

(2016) Steven E. Mansoor et al.   NATURE

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Cannabidiol Mellows Out Resurgent Sodium Current

(2016) Christopher H. Thompson et al.   Epilepsy Currents

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Selective potentiation of 2-APB-induced activation of TRPV1–3 channels by acid

(2016) Luna Gao et al.   Scientific Reports

Engineering vanilloid-sensitivity into the rat TRPV2 channel

(2016) Feng Zhang et al.   eLife

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

(2016) Chanhyung Bae et al.   eLife

An external sodium ion binding site controls allosteric gating in TRPV1 channels

(2016) Andres Jara-Oseguera et al.   eLife

How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy

(2015) Monique S. J. Brewster et al.   BIOESSAYS

Comparative sequence analysis suggests a conserved gating mechanism for TRP channels

(2015) Eugene Palovcak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Structure alignment of membrane proteins: Accuracy of available tools and a consensus strategy

(2015) Marcus Stamm et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation

(2014) Samia Hassan et al.   BRITISH JOURNAL OF PHARMACOLOGY

A series of PDB-related databanks for everyday needs

(2014) Wouter G. Touw et al.   NUCLEIC ACIDS RESEARCH

Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors

(2013) Mohamed Mahgoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB)

(2012) Gergely Kovacs et al.   CELL CALCIUM

2-Aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism

(2012) Rikki Chokshi et al.   Channels

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

(2012) Jianjun Pan et al.   Nature Communications

Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2

(2011) Eleonora Zakharian et al.   FASEB JOURNAL

Regulation of TRPM8 channel activity

(2011) Yevgen Yudin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

The history of TRP channels, a commentary and reflection

(2011) Craig Montell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

How significant is a protein structure similarity with TM-score = 0.5?

(2010) Jinrui Xu et al.   BIOINFORMATICS

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

The elusive π-helix

(2010) R. Peter Riek et al.   JOURNAL OF STRUCTURAL BIOLOGY

Biopython: freely available Python tools for computational molecular biology and bioinformatics

(2009) P. J. A. Cock et al.   BIOINFORMATICS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Fr-TM-align: a new protein structural alignment method based on fragment alignments and the TM-score

(2009) Shashi Pandit et al.   BMC BIOINFORMATICS

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4

(2009) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

(2008) K Togashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Recombinant Human T-type Calcium Channels by Δ9-Tetrahydrocannabinol and Cannabidiol

(2008) Hamish Redmond Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Properties of the Inner Pore Region of TRPV1 Channels Revealed by Block with Quaternary Ammoniums

(2008) Andrés Jara-Oseguera et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

(2008) N. Qin et al.   JOURNAL OF NEUROSCIENCE

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect

(2005) Shang-Zhong Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY