☆ 4.7 Article

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

SCIENTIFIC REPORTS (2017)

期刊

SCIENTIFIC REPORTS

卷 7, 期 -, 页码 -

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NATURE PUBLISHING GROUP

DOI: 10.1038/s41598-017-10993-9

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Multidisciplinary Sciences

资金

NIH [R01 NS083660, R01 CA206573, T32 GM008281]
Pew Scholar Award in Biomedical Sciences
Irma T. Hirschl Career Scientist Award

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摘要

Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

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