Structural insights into TRPM8 inhibition and desensitization

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Ca2+ Regulation of TRP Ion Channels

(2018) Raquibul Hasan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison

(2018) María Pertusa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy

(2018) M. Gregor Madej et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

(2018) Wang Zheng et al.   Cell Reports

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

(2018) Rozbeh Baradaran et al.   NATURE

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

Structure and gating mechanism of the transient receptor potential channel TRPV3

(2018) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of TRPV2 in distinct conformations provide insight into role of the pore turret

(2018) Timothy L. Dosey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights on TRPV5 gating by endogenous modulators

(2018) Taylor E. T. Hughes et al.   Nature Communications

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cough and airway disease: The role of ion channels

(2017) Sara J. Bonvini et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters

(2017) Vanessa Matos-Cruz et al.   Cell Reports

A pipeline approach to single-particle processing inRELION

(2017) Rafael Fernandez-Leiro et al.   Acta Crystallographica Section D-Structural Biology

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Modulation of Thermoreceptor TRPM8 by Cooling Compounds

(2012) Sonali S. Bharate et al.   ACS Chemical Neuroscience

N-Glycosylation of TRPM8 Ion Channels Modulates Temperature Sensitivity of Cold Thermoreceptor Neurons

(2012) María Pertusa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology

(2012) V. Blair Journigan et al.   LIFE SCIENCES

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

TRPM8 acute desensitization is mediated by calmodulin and requires PIP2: distinction from tachyphylaxis

(2011) Ignacio Sarria et al.   JOURNAL OF NEUROPHYSIOLOGY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TRPM8: From Cold to Cancer, Peppermint to Pain

(2010) Wendy M. Knowlton et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

(2010) Daniel J. Parks et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gating of Transient Receptor Potential Melastatin 8 (TRPM8) Channels Activated by Cold and Chemical Agonists in Planar Lipid Bilayers

(2010) E. Zakharian et al.   JOURNAL OF NEUROSCIENCE

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sensing voltage across lipid membranes

(2008) Kenton J. Swartz   NATURE