Structural basis for pharmacological modulation of the TRPC6 channel

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

(2019) Brian Leei Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

(2019) Jingjing Duan et al.   Science Advances

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

A structural overview of the ion channels of the TRPM family

(2019) Yihe Huang et al.   CELL CALCIUM

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

(2018) Qinglin Tang et al.   CELL RESEARCH

Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6)

(2018) Caleigh M. Azumaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel

(2018) Michaela Lichtenegger et al.   Nature Chemical Biology

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

(2018) Appu K. Singh et al.   Nature Communications

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

(2018) Deivanayagabarathy Vinayagam et al.   eLife

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

Structure–function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating

(2018) Francisco Sierra-Valdez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the mouse TRPC4 ion channel

(2018) Jingjing Duan et al.   Nature Communications

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Automated tilt series alignment and tomographic reconstruction in IMOD

(2017) David N. Mastronarde et al.   JOURNAL OF STRUCTURAL BIOLOGY

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

X-ray structures define human P2X3 receptor gating cycle and antagonist action

(2016) Steven E. Mansoor et al.   NATURE

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

(2016) Lin Tang et al.   NATURE

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels

(2015) T Maier et al.   BRITISH JOURNAL OF PHARMACOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy

(2014) K. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?

(2013) Robin S Bon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

A novel TRPC6mutation in a family with podocytopathy and clinical variability

(2013) Amy K Mottl et al.   BMC Nephrology

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

(2012) Jennifer Davis et al.   DEVELOPMENTAL CELL

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

(2012) Jian Xie et al.   Nature Communications

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TRPC channels are necessary mediators of pathologic cardiac hypertrophy

(2010) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

(2010) D. Tian et al.   Science Signaling

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Novel TRPC6 Mutation That Causes Childhood FSGS

(2009) Saskia F. Heeringa et al.   PLoS One