标题
Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition
作者
关键词
-
出版物
Biomolecules
Volume 10, Issue 5, Pages 697
出版商
MDPI AG
发表日期
2020-05-05
DOI
10.3390/biom10050697
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Hydroxylamine and Carboxymethoxylamine Can Inhibit Toxoplasma gondii Growth through an Aspartate Aminotransferase-Independent Pathway
- (2020) Jixu Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism
- (2020) Francisco Portillo et al. BIOCHIMIE
- The re‐emerging pathophysiological role of the cystathionine‐β‐synthase ‐ hydrogen sulfide system in Down syndrome
- (2020) Csaba Szabo FEBS Journal
- Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy
- (2020) Anne McMahon et al. JOURNAL OF CONTROLLED RELEASE
- Jan Kraus PhD., Professor of Pediatrics at the University of Colorado Anschutz Medical Campus, Aurora, CO, USA (b London, UK, June 5, 1942; q 1965 Faculty of Science Prague, d July 4, 2019, CO, USA)
- (2020) Brian Fowler et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
- (2020) Vikram Saini et al. Nature Communications
- Clinical Significance of CBS and CCL21 in Gallbladder Adenocarcinomas and Squamous Cell/Adenosquamous Carcinomas
- (2020) Daiqiang Li et al. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
- Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells
- (2020) Fiona Augsburger et al. Biomolecules
- Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats
- (2019) José Eduardo Roa-Coria et al. BMC NEUROSCIENCE
- Down syndrome: neurobiological alterations and therapeutic targets
- (2019) Rosa Anna Vacca et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods
- (2019) Karim Zuhra et al. Scientific Reports
- A Practical Review of Proteasome Pharmacology
- (2019) Tiffany A. Thibaudeau et al. PHARMACOLOGICAL REVIEWS
- Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA
- (2019) Min Wang et al. CELL DEATH AND DIFFERENTIATION
- Involvement of Endothelin-1, H2S and Nrf2 in Beneficial Effects of Remote Ischemic Preconditioning in Global Cerebral Ischemia-Induced Vascular Dementia in Mice
- (2019) Jin-Ting He et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Impact of Pharmacological Inhibition of Hydrogen Sulphide Production in the SOD1G93A-ALS Mouse Model
- (2019) Alida Spalloni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions
- (2019) Maria Sobol et al. MOLECULAR NEUROBIOLOGY
- Hydrogen sulfide suppresses homocysteine-induced glial activation and inflammatory response
- (2019) Mohit Kumar et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Central administration of aminooxyacetate, an inhibitor of H2S production, affects thermoregulatory but not cardiovascular and ventilatory responses to hypercapnia in spontaneously hypertensive rats
- (2019) João Paulo J. Sabino et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction
- (2019) Sumit Kar et al. Frontiers in Physiology
- S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2
- (2019) Restituto Tocmo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway
- (2019) Lupeng Wang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- NMR experiments on the transient interaction of the intrinsically disordered N-terminal peptide of cystathionine-β-synthase with heme
- (2019) Amit Kumar et al. JOURNAL OF MAGNETIC RESONANCE
- Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade
- (2019) Suravi Majumder et al. CELLULAR SIGNALLING
- Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy
- (2019) Tomas Majtan et al. FASEB JOURNAL
- A key leader in homocystinuria research: Jan P. Kraus (1942–2019)
- (2019) Viktor Kožich et al. HUMAN MUTATION
- Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome
- (2019) Theodora Panagaki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter
- (2019) Peng Zhao et al. Cell Death & Disease
- Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology
- (2019) Masayuki Ide et al. EMBO Molecular Medicine
- Mental retardation in Down syndrome: Two ways to treat
- (2019) Pierre P. Kamoun MEDICAL HYPOTHESES
- Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics
- (2019) Turtushikh Damba et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Imbalance of Homocysteine and H2S: Significance, Mechanisms, and Therapeutic Promise in Vascular Injury
- (2019) Qin Yang et al. Oxidative Medicine and Cellular Longevity
- Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation
- (2019) Inês Santos et al. Nutrients
- Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1α activation
- (2019) Mingqi Wang et al. BIOCHEMICAL PHARMACOLOGY
- Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies
- (2019) Erez M. Bublil et al. BIOCHIMIE
- Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
- (2019) Nan Liu et al. BRITISH JOURNAL OF CANCER
- Inhibition of hydrogen sulfide synthesis reverses acquired resistance to 5-FU through miR-215-5p-EREG/TYMS axis in colon cancer cells
- (2019) Shanwen Chen et al. CANCER LETTERS
- Hydrogen sulfide attenuates hyperhomocysteinemia-induced mitochondrial dysfunctions in brain
- (2019) Mohit Kumar et al. MITOCHONDRION
- Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling
- (2019) Wen Shen et al. Redox Biology
- Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulphide and cystathionine-β-synthase
- (2018) J. Donovan et al. Acta Physiologica
- Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase
- (2018) Tomas Majtan et al. ANTIOXIDANTS & REDOX SIGNALING
- Hydrogen sulfide in the regulation of insulin secretion and insulin sensitivity: Implications for the pathogenesis and treatment of diabetes mellitus
- (2018) Jerzy Bełtowski et al. BIOCHEMICAL PHARMACOLOGY
- A timeline of hydrogen sulfide (H 2 S) research: From environmental toxin to biological mediator
- (2018) Csaba Szabo BIOCHEMICAL PHARMACOLOGY
- Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation
- (2018) Gabor Oláh et al. BIOCHEMICAL PHARMACOLOGY
- Drug resistance induces the upregulation of H 2 S-producing enzymes in HCT116 colon cancer cells
- (2018) Ashley A. Untereiner et al. BIOCHEMICAL PHARMACOLOGY
- Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time
- (2018) Yupeng Tu et al. BIOCHEMISTRY
- Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis
- (2018) Fengjiao Zheng et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Endogenous H2S producing enzymes are involved in apoptosis induction in clear cell renal cell carcinoma
- (2018) Jan Breza et al. BMC CANCER
- Homocysteine and Hyperhomocysteinaemia
- (2018) Bozidarka L. Zaric et al. CURRENT MEDICINAL CHEMISTRY
- Exogenous hydrogen sulfide protects from endothelial cell damage, platelet activation, and neutrophils extracellular traps formation in hyperhomocysteinemia rats
- (2018) Ziqing Zhao et al. EXPERIMENTAL CELL RESEARCH
- Cystathionine β-synthase regulates mitochondrial morphogenesis in ovarian cancer
- (2018) Prabir Kumar Chakraborty et al. FASEB JOURNAL
- Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism
- (2018) Kenneth N. Maclean et al. FASEB JOURNAL
- Mitochondria as pharmacological targets in Down syndrome
- (2018) Daniela Valenti et al. FREE RADICAL BIOLOGY AND MEDICINE
- Inductive effect of Zoletil on cystathionine β-synthase expression in the rat brain
- (2018) De-Zhang Lu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells
- (2018) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond
- (2018) Weining Niu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reduction of hydrogen sulfide synthesis enzymes cystathionine-β-synthase and cystathionine-γ-lyase in the colon of patients with Hirschsprungs disease
- (2018) Christian Tomuschat et al. JOURNAL OF PEDIATRIC SURGERY
- An evaluation of the antioxidant and anticancer properties of complex compounds of copper(II), platinum(II), palladium(II) and ruthenium(III) for use in cancer therapy
- (2018) Anna Katarzyna Szczepanska et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets
- (2018) Antonella Izzo et al. MOLECULAR MEDICINE
- UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
- (2018) Vyacheslav Akimov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System
- (2018) Ulfuara Shefa et al. Oxidative Medicine and Cellular Longevity
- Blocking Endogenous H2S Signaling Attenuated Radiation-Induced Long-Term Metastasis of Residual HepG2 Cells through Inhibition of EMT
- (2018) Hang Zhang et al. RADIATION RESEARCH
- Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancer in vitro and in vivo
- (2018) Weining Niu et al. MedChemComm
- Increased H2S and its synthases in urothelial cell carcinoma of the bladder, and enhanced cisplatin‑induced apoptosis following H2S inhibition in EJ cells
- (2018) Wasilijiang Wahafu et al. Oncology Letters
- UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
- (2018) Vyacheslav Akimov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism
- (2018) Maria Caracausi et al. Scientific Reports
- Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase
- (2018) Amit Kumar et al. Scientific Reports
- Cystathionine β-Synthase in Physiology and Cancer
- (2018) Haoran Zhu et al. Biomed Research International
- Integrated Quantitative Transcriptome Maps of Human Trisomy 21 Tissues and Cells
- (2018) Maria Chiara Pelleri et al. Frontiers in Genetics
- Sulfide Protects Staphylococcus aureus from Aminoglycoside Antibiotics but Cannot Be Regarded as a General Defense Mechanism against Antibiotics
- (2018) Julia Weikum et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Differentially expressed gene (DEG) based protein-protein interaction (PPI) network identifies a spectrum of gene interactome, transcriptome and correlated miRNA in nondisjunction Down syndrome
- (2018) Ramireddy Sriroopreddy et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain
- (2018) J. London et al. MOLECULAR NEUROBIOLOGY
- Aminooxyacetic acid improves learning and memory in a rat model of chronic alcoholism
- (2018) Yu-Ming Xu et al. Neural Regeneration Research
- A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis
- (2018) Li Wang et al. Cell Death & Disease
- Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism
- (2018) Jyotirmaya Behera et al. Scientific Reports
- Cystathione β-Synthase Is Increased in Thyroid Malignancies
- (2018) ELBA A. TURBAT-HERRERA et al. ANTICANCER RESEARCH
- E2β stimulates ovine uterine artery endothelial cell H2S production in vitro by estrogen receptor-dependent upregulation of cystathionine β-synthase and cystathionine γ-lyase expression†
- (2018) Thomas J Lechuga et al. BIOLOGY OF REPRODUCTION
- Endogenous H2S production deficiencies lead to impaired renal erythropoietin production
- (2018) Jennifer Leigh et al. CUAJ-Canadian Urological Association Journal
- Cystathionine B-synthase induces multidrug resistance and metastasis in hepatocellular carcinoma
- (2018) Lupeng Wang et al. CURRENT MOLECULAR MEDICINE
- H2S, a Bacterial Defense Mechanism against the Host Immune Response
- (2018) Tracy Toliver-Kinsky et al. INFECTION AND IMMUNITY
- Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase
- (2018) Youtian Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—hydrogen sulfide (H2S) pathway in cancer cells
- (2018) Fiona Augsburger et al. PHARMACOLOGICAL RESEARCH
- Hydrogen Sulfide Affects Radical Formation in the Hippocampus of LPS Treated Rats and the Effect of Antipsychotics on Hydrogen Sulfide Forming Enzymes in Human Cell Lines
- (2018) Olaf Sommer et al. Frontiers in Psychiatry
- Carbon monoxide sensitizes cisplatin-resistant ovarian cancer cell lines toward cisplatin via attenuation of levels of glutathione and nuclear metallothionein
- (2018) Brian Kawahara et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Cystathionine β-synthase is required for body iron homeostasis
- (2017) Yu-Fu Zhou et al. HEPATOLOGY
- Increased Plasma Homocysteine Level is Associated with Executive Dysfunction in Type 2 Diabetic Patients with Mild Cognitive Impairment
- (2017) Sai Tian et al. JOURNAL OF ALZHEIMERS DISEASE
- Initial Decomposition Pathways of Aqueous Hydroxylamine Solutions
- (2017) Yu-ichiro Izato et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Loss of the Protein Cystathionine β-Synthase During Kidney Injury Promotes Renal Tubulointerstitial Fibrosis
- (2017) Xiangning Yuan et al. KIDNEY & BLOOD PRESSURE RESEARCH
- Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells
- (2017) Jarosław Paluszczak et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Cystathionine β-synthase deficiency: Of mice and men
- (2017) Warren D. Kruger MOLECULAR GENETICS AND METABOLISM
- Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement
- (2017) Haiya Pu et al. Molecular Medicine Reports
- Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
- (2017) Zdenek Skrott et al. NATURE
- Antidiarrheal effect of sodium hydrosulfide in diabetic rats: In vitro and in vivo studies
- (2017) M. Saghazadeh-Dezfuli et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system
- (2017) Huina Jia et al. ONCOLOGY REPORTS
- International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H 2 S Levels: H 2 S Donors and H 2 S Biosynthesis Inhibitors
- (2017) Csaba Szabo et al. PHARMACOLOGICAL REVIEWS
- Cystathionine-β-synthase-derived hydrogen sulfide is required for amygdalar long-term potentiation and cued fear memory in rats
- (2017) Hai-Bo Chen et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate
- (2017) Naveed A. Nadvi et al. PROTEIN SCIENCE
- Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe
- (2017) Weining Niu et al. MedChemComm
- Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
- (2017) Yansheng Liu et al. Nature Communications
- Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
- (2017) Kenjiro Hanaoka et al. Scientific Reports
- Neuroprotective Roles of l-Cysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H2S Pathway Following Subarachnoid Hemorrhage in Rats
- (2017) Tong Li et al. Frontiers in Neurology
- Cystathionine: A novel oncometabolite in human breast cancer
- (2016) Suvajit Sen et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase
- (2016) João B. Vicente et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Effects of Dietary Selenium on Inflammation and Hydrogen Sulfide in the Gastrointestinal Tract in Chickens
- (2016) Cong Wu et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis
- (2016) Caixia Wang et al. CANCER LETTERS
- Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair
- (2016) Catherine Alix-Panabières et al. CLINICAL CHEMISTRY
- Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions
- (2016) Tomas Majtan et al. CURRENT DRUG TARGETS
- Identification and characterization of PKF118-310 as a KDM4A inhibitor
- (2016) Gianluigi Franci et al. Epigenetics
- Upregulation of CBS/H2S system contributes to asymmetric dimethylarginine-triggered protection against the neurotoxicity of glutamate to PC12 cells by inhibiting NOS/NO pathway
- (2016) Xiang-Yu Wang et al. EXPERIMENTAL CELL RESEARCH
- Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration
- (2016) Sounik Saha et al. FASEB JOURNAL
- Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding
- (2016) Angel L. Pey et al. FEBS LETTERS
- Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase
- (2016) Akbar Ahmad et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine β-Synthase
- (2016) Sebastián Carballal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model
- (2016) Erez M. Bublil et al. JOURNAL OF CLINICAL INVESTIGATION
- Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
- (2016) Andrew A. M. Morris et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Hydrogen Sulfide Induced Erythropoietin Synthesis is Regulated by HIF Proteins
- (2016) Jennifer Leigh et al. JOURNAL OF UROLOGY
- Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach
- (2016) Celia Chao et al. MOLECULAR MEDICINE
- Effects of hydrogen sulfide on the expression of alkaline phosphatase, osteocalcin and collagen type I in human periodontal ligament cells induced by tension force stimulation
- (2016) Jing Qin et al. Molecular Medicine Reports
- Proteogenomics connects somatic mutations to signalling in breast cancer
- (2016) Philipp Mertins et al. NATURE
- Cancer metabolism: a therapeutic perspective
- (2016) Ubaldo E. Martinez-Outschoorn et al. Nature Reviews Clinical Oncology
- The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction
- (2016) Na Li et al. Oxidative Medicine and Cellular Longevity
- Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer
- (2016) Nadiya Druzhyna et al. PHARMACOLOGICAL RESEARCH
- Both the H 2 S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H 2 S donor AP39 exert protective effects in a mouse model of burn injury
- (2016) Akbar Ahmad et al. PHARMACOLOGICAL RESEARCH
- Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure
- (2016) Eunyoung Lee et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
- (2016) Yujun Hao et al. Nature Communications
- Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants
- (2016) Carlos Alberto Moreira-Filho et al. Oncotarget
- Multiomic Analysis of the UV-Induced DNA Damage Response
- (2016) Stefan Boeing et al. Cell Reports
- Trisomy 21 consistently activates the interferon response
- (2016) Kelly D Sullivan et al. eLife
- Uranium-induced rat kidney cell cytotoxicity is mediated by decreased endogenous hydrogen sulfide (H2S) generation involved in reduced Nrf2 levels
- (2016) Yan Yuan et al. Toxicology Research
- “Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model
- (2016) Christopher D. McCune et al. ACS Central Science
- An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome
- (2016) Faycal Guedj et al. Scientific Reports
- Urothelium muscarinic activation phosphorylates CBSSer227 via cGMP/PKG pathway causing human bladder relaxation through H2S production
- (2016) Roberta d’Emmanuele di Villa Bianca et al. Scientific Reports
- Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics
- (2016) Bartosz Szczesny et al. Scientific Reports
- rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment
- (2016) Annapina Russo et al. Scientific Reports
- The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I
- (2015) Elisa Oppici et al. ACS Chemical Biology
- Cystathionine-β-Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive Rats
- (2015) Xiao-Cui Duan et al. AMERICAN JOURNAL OF HYPERTENSION
- The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice
- (2015) Warren D. Kruger et al. Annals of the New York Academy of Sciences
- The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer
- (2015) Mark R. Hellmich et al. ANTIOXIDANTS & REDOX SIGNALING
- S-Glutathionylation Enhances Human Cystathionine β-Synthase Activity Under Oxidative Stress Conditions
- (2015) Wei-Ning Niu et al. ANTIOXIDANTS & REDOX SIGNALING
- Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications
- (2015) Sudhakar Veeranki et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells
- (2015) Cinzia Franchin et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Chemistry and diversity of pyridoxal-5′-phosphate dependent enzymes
- (2015) Robert S. Phillips BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Marine natural products as inhibitors of cystathionine beta-synthase activity
- (2015) Megan K. Thorson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The CBS/CSE system: a potential therapeutic target in NAFLD?
- (2015) Lindsei K. Sarna et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits
- (2015) Christopher Hine et al. CELL
- Enzymatic diagnosis of homocystinuria by determination of cystathionine-ß-synthase activity in plasma using LC-MS/MS
- (2015) P. Alcaide et al. CLINICA CHIMICA ACTA
- Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate
- (2015) P. Korangath et al. CLINICAL CANCER RESEARCH
- Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S–Nampt
- (2015) Elena A. Ostrakhovitch et al. EXPERIMENTAL CELL RESEARCH
- Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China
- (2015) Fang Ye et al. FASEB JOURNAL
- Role of cystathionine β-synthase in human breast Cancer
- (2015) Suvajit Sen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis
- (2015) Ruili Yang et al. IMMUNITY
- Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats
- (2015) Maryam Hadadha et al. Journal of Stroke & Cerebrovascular Diseases
- Tyrosol Attenuates High Fat Diet-Induced Hepatic Oxidative Stress: Potential Involvement of Cystathionine β-Synthase and Cystathionine γ-Lyase
- (2015) Lindsei K. Sarna et al. LIPIDS
- Targeting copper in cancer therapy: ‘Copper That Cancer’
- (2015) Delphine Denoyer et al. Metallomics
- A Phosphoproteomic Comparison of B-RAFV600Eand MKK1/2 Inhibitors in Melanoma Cells
- (2015) Scott A. Stuart et al. MOLECULAR & CELLULAR PROTEOMICS
- Gasotransmitters in cancer: from pathophysiology to experimental therapy
- (2015) Csaba Szabo NATURE REVIEWS DRUG DISCOVERY
- Hydrogen sulfide protects testicular germ cells against heat-induced injury
- (2015) Guang Li et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Down-regulated CBS/H2S pathway is involved in high-salt-induced hypertension in Dahl rats
- (2015) Pan Huang et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- Role of cystathionine beta synthase in lipid metabolism in ovarian cancer
- (2015) Prabir K Chakraborty et al. Oncotarget
- Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats
- (2015) Maryam Hadadha et al. Journal of Stroke & Cerebrovascular Diseases
- Hydrogen Sulfide Promotes Adipogenesis in 3T3L1 Cells
- (2015) Chin-Yi Tsai et al. PLoS One
- Alterations of Retinal Vasculature in Cystathionine–β-Synthase Heterozygous Mice
- (2014) Amany Tawfik et al. AMERICAN JOURNAL OF PATHOLOGY
- CBS and CSE Are Critical for Maintenance of Mitochondrial Function and Glucocorticoid Production in Adrenal Cortex
- (2014) Chang-Nan Wang et al. ANTIOXIDANTS & REDOX SIGNALING
- Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type
- (2014) Chenchen Du et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Copper Signaling Axis as a Target for Prostate Cancer Therapeutics
- (2014) R. Safi et al. CANCER RESEARCH
- A Proteome-Scale Map of the Human Interactome Network
- (2014) Thomas Rolland et al. CELL
- Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers
- (2014) Jing Liu et al. CHEMICAL REVIEWS
- Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide
- (2014) Sathnur Pushpakumar et al. CURRENT MEDICINAL CHEMISTRY
- Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency
- (2014) Ruben Esse et al. FASEB JOURNAL
- Inter-domain Communication of Human Cystathionine β-Synthase
- (2014) Thomas J. McCorvie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons
- (2014) Ryo Miyamoto et al. JOURNAL OF NEUROCHEMISTRY
- Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
- (2014) Jie Zha et al. Journal of Translational Medicine
- Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome
- (2014) Daniela Valenti et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Hippocampal cystathionine beta synthase in young and aged mice
- (2014) J.J. Bruintjes et al. NEUROSCIENCE LETTERS
- Hydrogen sulfide and the liver
- (2014) Sarathi Mani et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Effect of S-adenosyl-l-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro
- (2014) Katalin Módis et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Nitrite Reductase Activity and Inhibition of H2S Biogenesis by Human Cystathionine ß-Synthase
- (2014) Carmen Gherasim et al. PLoS One
- A H2S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells
- (2014) Reiko Sanokawa-Akakura et al. PLoS One
- Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases
- (2014) Tomas Majtan et al. PLoS One
- Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase byS-adenosylmethionine
- (2014) June Ereño-Orbea et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Androgen receptor (AR) suppresses normal human prostate epithelial cell proliferation via AR/β-catenin/TCF-4 complex inhibition ofc-MYCtranscription
- (2014) Lizamma Antony et al. PROSTATE
- Salutary Effect of Aurintricarboxylic Acid on Endotoxin- and Sepsis-Induced Changes in Muscle Protein Synthesis and Inflammation
- (2014) Lacee J. Laufenberg et al. SHOCK
- Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
- (2014) Kirti Sharma et al. Cell Reports
- Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe
- (2013) Megan K. Thorson et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Enzymology of H2S Biogenesis, Decay and Signaling
- (2013) Omer Kabil et al. ANTIOXIDANTS & REDOX SIGNALING
- CBS domains: Ligand binding sites and conformational variability
- (2013) June Ereño-Orbea et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Further evidence of endogenous hydrogen sulphide as a mediator of relaxation in human and rat bladder
- (2013) Jun-Wei Gai et al. ASIAN JOURNAL OF ANDROLOGY
- Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow
- (2013) Liman Luo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression
- (2013) Naoharu Takano et al. BIOCHEMICAL JOURNAL
- Sulfide inhibition of and metabolism by cytochromecoxidase
- (2013) Peter Nicholls et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)
- (2013) Antonia Asimakopoulou et al. BRITISH JOURNAL OF PHARMACOLOGY
- Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms
- (2013) Csaba Szabo et al. BRITISH JOURNAL OF PHARMACOLOGY
- Inhibition of cystathionine β-synthase is associated with glucocorticoids over-secretion in psychological stress-induced hyperhomocystinemia rat liver
- (2013) Yun Zhao et al. CELL STRESS & CHAPERONES
- High-throughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathway
- (2013) Yueyang Zhou et al. CHEMICAL COMMUNICATIONS
- Characterization of two pathogenic mutations in cystathionine beta-synthase: Different intracellular locations for wild-type and mutant proteins
- (2013) L. Casique et al. GENE
- Correction of Cystathionine β-Synthase Deficiency in Mice by Treatment with Proteasome Inhibitors
- (2013) Sapna Gupta et al. HUMAN MUTATION
- Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects
- (2013) GILDON CHOI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The Expression Changes of Cystathionine-β-synthase in Brain Cortex After Traumatic Brain Injury
- (2013) Mingyang Zhang et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons
- (2013) I. Llorente-Folch et al. JOURNAL OF NEUROSCIENCE
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome
- (2013) Yangyang Bian et al. Journal of Proteomics
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- Role of hydrogen sulfide in secondary neuronal injury
- (2013) Jun-Feng Wang et al. NEUROCHEMISTRY INTERNATIONAL
- l-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway
- (2013) Z. Wang et al. NEUROSCIENCE
- Hydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice
- (2013) P.K. Kamat et al. NEUROSCIENCE
- Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance
- (2013) Sanjib Bhattacharyya et al. PLoS One
- Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
- (2013) C. Szabo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of regulation and oligomerization of human cystathionine -synthase, the central enzyme of transsulfuration
- (2013) J. Ereno-Orbea et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxygen-sensitive mitochondrial accumulation of cystathionine -synthase mediated by Lon protease
- (2013) H. Teng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia
- (2013) R. d'Emmanuele di Villa Bianca et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar/AGC1
- (2013) Beatriz Pardo et al. Frontiers in Endocrinology
- Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia
- (2012) Utpal Sen et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
- (2012) Jan Lewerenz et al. ANTIOXIDANTS & REDOX SIGNALING
- The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613
- (2012) John M. Hourihan et al. ANTIOXIDANTS & REDOX SIGNALING
- Human cystathionine β-synthase (CBS) contains two classes of binding sites forS-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM
- (2012) Angel L. Pey et al. BIOCHEMICAL JOURNAL
- Hydrogen sulphide-induced relaxation of porcine peripheral bronchioles
- (2012) S Rashid et al. BRITISH JOURNAL OF PHARMACOLOGY
- Severe Hyperhomocysteinemia Promotes Bone Marrow–Derived and Resident Inflammatory Monocyte Differentiation and Atherosclerosis in LDLr/CBS-Deficient Mice
- (2012) Daqing Zhang et al. CIRCULATION RESEARCH
- Detection of Reaction Intermediates during Human Cystathionine β-Synthase-monitored Turnover and H2S Production
- (2012) Pramod Kumar Yadav et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster
- (2012) F. Talaei et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- Aurintricarboxylic Acid Ameliorates Experimental Autoimmune Encephalomyelitis by Blocking Chemokine-Mediated Pathogenic Cell Migration and Infiltration
- (2012) F. Zhang et al. JOURNAL OF IMMUNOLOGY
- Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome
- (2012) Houjiang Zhou et al. JOURNAL OF PROTEOME RESEARCH
- Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
- (2012) Martin Klammer et al. MOLECULAR & CELLULAR PROTEOMICS
- Promoter demethylation of cystathionine-β-synthetase gene contributes to inflammatory pain in rats
- (2012) Feihu Qi et al. PAIN
- Synergizing Genomic Analysis With Biological Knowledge to Identify and Validate Novel Genes in Pancreatic Development
- (2012) Suparna A. Sarkar et al. PANCREAS
- Characterization of Hydrogen Sulfide and Its Synthases, Cystathionine β-Synthase and Cystathionine γ-Lyase, in Human Prostatic Tissue and Cells
- (2012) Hui Guo et al. UROLOGY
- Interdependency of Cystathione -Lyase and Cystathione -Synthase in Hydrogen Sulfide-Induced Blood Pressure Regulation in Rats
- (2011) A. Roy et al. AMERICAN JOURNAL OF HYPERTENSION
- The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues
- (2011) Omer Kabil et al. ANTIOXIDANTS & REDOX SIGNALING
- Hydrogen Sulfide Ameliorates Tobacco Smoke-Induced Oxidative Stress and Emphysema in Mice
- (2011) Weihong Han et al. ANTIOXIDANTS & REDOX SIGNALING
- PLP-dependent H2S biogenesis
- (2011) Sangita Singh et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Possible role of cysteine-S-conjugate β-lyase in species differences in cisplatin nephrotoxicity
- (2011) Rieko Katayama et al. FOOD AND CHEMICAL TOXICOLOGY
- Hydrogen Sulfide Is an Endogenous Potentiator of T Cell Activation
- (2011) Thomas W. Miller et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase
- (2011) Carsten Kriebitzsch et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy
- (2011) Di Chen et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract
- (2011) James R. Austgen et al. JOURNAL OF NEUROPHYSIOLOGY
- Hydrogen Sulfide Contributes to Hypoxia-induced Radioresistance on Hepatoma Cells
- (2011) Jianghong ZHANG et al. JOURNAL OF RADIATION RESEARCH
- The association of Cystathionine β Synthase (CBS) T833C polymorphism and the risk of stroke: A meta-analysis
- (2011) Rui Ding et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Endogenous Production of Hydrogen Sulfide in Isolated Bovine Eye
- (2011) Madhura Kulkarni et al. NEUROCHEMICAL RESEARCH
- Expression of Cystathionine β-synthase and Cystathionine γ-lyase in Human Pregnant Myometrium and Their Roles in the Control of Uterine Contractility
- (2011) Xing-Ji You et al. PLoS One
- Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/ H2S Pathway
- (2011) Fatemeh Talaei et al. PLoS One
- Cystathionine Beta-Synthase Deficiency Causes Fat Loss in Mice
- (2011) Sapna Gupta et al. PLoS One
- Effects of Hydrogen Sulfide Synthesis Inhibitors on Posthypoxic Ventilatory Behavior in the C57BL/6J Mouse
- (2011) Lucas M. Donovan et al. RESPIRATION
- Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells
- (2011) Katarzyna Walczak et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- H2S: A Universal Defense Against Antibiotics in Bacteria
- (2011) K. Shatalin et al. SCIENCE
- System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation
- (2011) K. T. G. Rigbolt et al. Science Signaling
- Sulfur amino acid metabolism in doxorubicin-resistant breast cancer cells
- (2011) Chang Seon Ryu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery
- (2011) Poulami Basu et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction
- (2010) Benjamin L. Predmore et al. AGE
- Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research
- (2010) Richard S. Beard et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mechanisms of Cardiovascular Remodeling in Hyperhomocysteinemia
- (2010) Mesia M. Steed et al. ANTIOXIDANTS & REDOX SIGNALING
- Cross-Talk between the Catalytic Core and the Regulatory Domain in Cystathionine β-Synthase: Study by Differential Covalent Labeling and Computational Modeling
- (2010) Aleš Hnízda et al. BIOCHEMISTRY
- Residue N84 of Yeast Cystathionine β-Synthase is a Determinant of Reaction Specificity
- (2010) Pratik H. Lodha et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice
- (2010) Kristian K. Jensen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Ischemia/Reperfusion Reduces Transcription Factor Sp1-mediated Cystathionine β-Synthase Expression in the Kidney
- (2010) Nan Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency
- (2010) Jakub Krijt et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Vascular presentation of cystathionine beta-synthase deficiency in adulthood
- (2010) Martin Magner et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Specific Inhibition of the Aspartate Aminotransferase of Plasmodium falciparum
- (2010) Carsten Wrenger et al. JOURNAL OF MOLECULAR BIOLOGY
- Mass Spectrometry Following Mild Enzymatic Digestion Reveals Phosphorylation of Recombinant Proteins inEscherichia coliThrough Mechanisms Involving Direct Nucleotide Binding
- (2010) Yi-Min She et al. JOURNAL OF PROTEOME RESEARCH
- The Plk1-dependent Phosphoproteome of the Early Mitotic Spindle
- (2010) Anna Santamaria et al. MOLECULAR & CELLULAR PROTEOMICS
- Phosphoproteome profile of human lung cancer cell line A549
- (2010) Guangchuang Yu et al. Molecular BioSystems
- A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment
- (2010) Kenneth N. Maclean et al. MOLECULAR GENETICS AND METABOLISM
- Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
- (2010) Kenneth N. Maclean et al. MOLECULAR GENETICS AND METABOLISM
- Burkholderia glumae: next major pathogen of rice?
- (2010) JONG HYUN HAM et al. MOLECULAR PLANT PATHOLOGY
- Inhibition of Hydrogen Sulfide Generation Contributes to 1-Methy-4-Phenylpyridinium Ion-Induced Neurotoxicity
- (2010) Xiao-Qing Tang et al. NEUROTOXICITY RESEARCH
- Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthase
- (2010) M. Koutmos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
- (2010) J. V. Olsen et al. Science Signaling
- Lys-N and Trypsin Cover Complementary Parts of the Phosphoproteome in a Refined SCX-Based Approach
- (2009) Sharon Gauci et al. ANALYTICAL CHEMISTRY
- High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth
- (2009) K. Iljin et al. CLINICAL CANCER RESEARCH
- Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells
- (2009) Pay-Chin Leow et al. INVESTIGATIONAL NEW DRUGS
- Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions
- (2009) Sangita Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Endogenous Hydrogen Sulfide Producing Enzyme Cystathionine-β Synthase Contributes to Visceral Hypersensitivity in a Rat Model of Irritable Bowel Syndrome
- (2009) Guang-Yin Xu et al. Molecular Pain
- Homocysteine levels after acute levodopa intake in patients with Parkinson's disease
- (2009) Thomas Müller et al. MOVEMENT DISORDERS
- Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide
- (2009) Moonhee Lee et al. NEUROBIOLOGY OF AGING
- Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver
- (2009) Natalia Guillén et al. PHYSIOLOGICAL GENOMICS
- The endogenous production of hydrogen sulphide in intrauterine tissues
- (2009) Pushpa Patel et al. Reproductive Biology and Endocrinology
- Crystal structure of ST2348, a CBS domain protein, from hyperthermophilic archaeon Sulfolobus tokodaii
- (2008) Preethi Ragunathan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice
- (2008) Julien Hamelet et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mouse models of cystathionine β-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia
- (2008) Sapna Gupta et al. FASEB JOURNAL
- Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose
- (2008) Yukiko Kaneko et al. FEBS LETTERS
- Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia
- (2008) Noriyuki Akahoshi et al. HUMAN MOLECULAR GENETICS
- Stimulation of osteoblast activity by homocysteine
- (2008) Markus Herrmann et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Mono- (Ag, Hg) and di- (Cu, Hg) valent metal ions effects on the activity of jack bean urease. Probing the modes of metal binding to the enzyme
- (2008) Barbara Krajewska JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats
- (2008) G.S. Dawe et al. NEUROSCIENCE
- Endogenous hydrogen sulfide is involved in regulation of respiration in medullary slice of neonatal rats
- (2008) H. Hu et al. NEUROSCIENCE
- The interconversion of ACC deaminase and d-cysteine desulfhydrase by directed mutagenesis
- (2008) Biljana Todorovic et al. PLANTA
- Human Polycomb 2 Protein Is a SUMO E3 Ligase and Alleviates Substrate-Induced Inhibition of Cystathionine β-Synthase Sumoylation
- (2008) Nitish Agrawal et al. PLoS One
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started