Article
Chemistry, Analytical
Taoyun Wang, Xu Huang, Sheng Yang, Shan Hu, Xianglan Zheng, Guojiang Mao, Yi Li, Yibo Zhou
Summary: In this study, a lysosome-targeted fluorogenic probe called NA-HS was developed for real-time monitoring of hydrogen sulfide (H2S) fluctuation during autophagic fusion. The probe exhibited good selectivity and high sensitivity, allowing imaging of exogenous and endogenous H2S in living cells. Results showed that H2S levels were upregulated after autophagy initiation and gradually reduced during subsequent autophagic fusion, providing insights into cellular signal pathways.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Li Li, Zhenmei Lin, Yongfang Cheng, Yaoping Tang, Ziqian Zhang
Summary: This study introduces a novel H2S donor, HSD560, which releases H2S triggered by cysteine, accompanied by enhanced green fluorescence for tracking H2S release in cells. The H2S release from HSD560 undergoes a non-enzymatic native chemical ligation process, accurately matching activated fluorescence and localizing H2S in zebrafish.
Article
Chemistry, Applied
Andrey Zagoruiko, Pavel Mikenin
Summary: The study showed that in a specific temperature range, high efficiency H2S decomposition can be achieved through chemisorption-catalytic process, with the reaction proceeding in a quasi-stationary mode. The hydrogen yield significantly exceeds the equilibrium values during this process.
Article
Chemistry, Analytical
Junli Peng, Qikai Ju, Baoshuai An, Zhengji Yin, Ningning Wei, Yanru Zhang
Summary: This study describes the design and biological applications of a novel fluorescence probe, SS-N-3, for the detection of hydrogen sulfide in vivo. The probe exhibits high selectivity and sensitivity to hydrogen sulfide, with strong anti-interference capacity. Additionally, the probe shows low cytotoxicity, improved photostability, and a large Stokes shift, making it an effective indicator of hydrogen sulfide levels in living cells.
Article
Chemistry, Multidisciplinary
Bingchen Yu, Ting Kang, Yuan Xu, Yiqing Liu, Yaru Ma, Bowen Ke
Summary: Persulfide prodrugs, such as hydrogen persulfide (H2S2), show increased pharmacological activities and reduced toxicity compared to hydrogen sulfide (H2S), indicating their potential as better therapeutic options.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Yang Ding, Zheng Li, Chenchen Xu, Wenjing Qin, Qiong Wu, Xuchun Wang, Xiamin Cheng, Lin Li, Wei Huang
Summary: Beta-lactam antibiotics are important inventions in treating infections, but the emergence of beta-lactamase in bacteria leads to drug resistance. Various detection methods and inhibitors are available, and designing improved probes may help overcome bacterial resistance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Hanchao Lin, Yixin Yu, Le Zhu, Nannan Lai, Luming Zhang, Yu Guo, Xinxin Lin, Dongqin Yang, Ning Ren, Zhiling Zhu, Qiongzhu Dong
Summary: Hydrogen sulfide (H2S) is a crucial signaling molecule in colorectal cancer (CRC), produced in the colon by enzymatic systems of colonocytes and released by intestinal microbes. Both endogenous and exogenous H2S contribute to the onset and progression of CRC. Recent advancements have led to the development of diagnostic probes, combination therapies, and tumor treatment approaches through H2S modulation for CRC. This review focuses on the mechanisms of H2S production and oxidative metabolism, as well as its role in CRC occurrence, progression, diagnosis, and treatment, providing insights into future research in this field.
Article
Chemistry, Analytical
Meng-Ya Guo, Wei Wang, Dilimulati Ainiwaer, Yu-Shun Yang, Bao-Zhong Wang, Jie Yang, Hai-Liang Zhu
Summary: A novel fluorescent probe, Rho-HS, was developed for detecting H2S with wide pH range, rapid response, high selectivity, and low cytotoxicity. It was successfully applied in biological imaging.
Review
Biochemistry & Molecular Biology
Joanna Myszkowska, Ilia Derevenkov, Sergei V. Makarov, Ute Spiekerkoetter, Luciana Hannibal
Summary: Hydrogen sulfide (H2S) plays important roles in human health, with its disease-promoting effects depending on concentration and compartmentalization. There is substantial discrepancy in H2S concentrations determined by different techniques, with no definitive protocol for continuous, real-time measurement.
Article
Chemistry, Analytical
Shaohui Han, Hui Zhang, Jingpei Wang, Lei Yang, Minhuan Lan, Benhua Wang, Xiangzhi Song
Summary: By introducing an active triple bond into the molecular structure, sensors with good selectivity for distinguishing and detecting H2S and SO2 can be constructed. These sensors can not only detect the target substances in a dual-ratiometric manner, but also be successfully applied in living cells and zebrafish.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kaylin G. Fosnacht, Matthew D. Hammers, Mary S. Earp, Annie K. Gilbert, Michael D. Pluth
Summary: A new fluorescent probe CT-MeRhoAz has been developed for the detection of H2S. The probe shows high selectivity and cell-trapping ability for H2S, and exhibits a significantly enhanced fluorescent signal in the presence of H2S.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Microbiology
Patricia G. Wolf, Elise S. Cowley, Adam Breister, Sarah Matatov, Luke Lucio, Paige Polak, Jason M. Ridlon, H. Rex Gaskins, Karthik Anantharaman
Summary: This study reveals that microbial sulfur metabolism in the human gut is more diverse and prevalent than previously known, and is statistically associated with colorectal cancer. The study also identifies new microbial genera associated with reductive taurine metabolism. Furthermore, the findings highlight the importance of organic sulfur substrates as a major source of H2S in the human gut.
Article
Chemistry, Analytical
Jiangfeng Li, Donghao Ding, Jiangyan Wang, Ling Huang, Jingting Zhan, Weiying Lin
Summary: A novel activatable near-infrared photoacoustic probe (PAP-H2S) was designed for monitoring H2S levels in a mouse inflammation model using PA imaging technology. The probe showed a 9.2-fold signal enhancement after being activated by H2S, providing a potential tool for diagnosing and monitoring inflammation-related diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Carolyn M. Levinn, Michael D. Pluth
Summary: This study reported two dioxetane-based chemiluminescent probes for hydrogen sulfide (H2S) detection. Results showed that the SNAr cleavage of the DNP group resulted in a larger response and greater stability in water.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Spectroscopy
Li Li, Ziqian Zhang
Summary: Hydrogen sulfide (H2S) is a crucial gasotransmitter in biological systems and is widely used in biological studies. A newly developed donor molecule, HSD545, triggers the release of H2S in response to reactive oxygen species (ROS) and simultaneously generates a fluorescent substance for real-time monitoring. The donor exhibits low cytotoxicity and provides strong cytoprotection against ROS-induced oxidative stress.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Genetics & Heredity
Tomas Majtan, Insun Park, Erez M. Bublil, Jan P. Kraus
Article
Biochemistry & Molecular Biology
Tomas Majtan, Jakub Krijt, Jitka Sokolova, Michaela Krizkova, Maria A. Ralat, Jana Kent, Jesse F. Gregory, Viktor Kozich, Jan P. Kraus
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Biochemistry & Molecular Biology
Tomas Majtan, Insun Park, Allaura Cox, Brian R. Branchford, Jorge di Paola, Erez M. Bublil, Jan P. Kraus
Biographical-Item
Genetics & Heredity
Viktor Kozich, Tomas Majtan
Review
Biochemistry & Molecular Biology
Karim Zuhra, Fiona Augsburger, Tomas Majtan, Csaba Szabo
Article
Genetics & Heredity
Insun Park, Helena Hulkova, Jakub Krijt, Viktor Kozich, Erez M. Bublil, Tomas Majtan
Article
Biochemistry & Molecular Biology
Insun Park, Linda K. Johnson, Allaura Cox, Brian R. Branchford, Jorge Di Paola, Erez M. Bublil, Tomas Majtan
Review
Endocrinology & Metabolism
Viktor Kozich, Tomas Majtan
Summary: The metabolism of sulfur amino acids (SAA) is essential for many cellular functions. Current treatments for genetic disorders of SAA metabolism involve dietary measures and provision of lacking products. Recent studies have identified additional therapeutic targets and explored novel treatments like chaperone and gene therapy.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2021)
Article
Chemistry, Multidisciplinary
Megan K. Youmans
JOURNAL OF CHEMICAL EDUCATION
(2020)
Article
Nutrition & Dietetics
Insun Park, Erez M. Bublil, Frank Glavin, Tomas Majtan
Article
Biochemistry & Molecular Biology
Theodora Panagaki, Laura Lozano-Montes, Lucia Janickova, Karim Zuhra, Marcell P. Szabo, Tomas Majtan, Gregor Rainer, Damien Marechal, Yann Herault, Csaba Szabo
Summary: This study investigates the functional role of the cystathionine-beta-synthase (CBS)/hydrogen sulfide (H2S) pathway in the pathogenesis of brain wave pattern alterations and neurobehavioral dysfunction in a rat model of Down syndrome (DS). The overexpression of CBS and subsequent overproduction of H2S in the brain of DS rats were observed. The study suggests that the CBS/H2S pathway contributes to the neurological dysfunction in DS through dysregulation of cellular bioenergetics and gene expression.
Article
Biochemistry & Molecular Biology
Maria Petrosino, Karim Zuhra, Jola Kopec, Andrew Hutchin, Csaba Szabo, Tomas Majtan
Summary: In this study, the binding and inhibitory mechanism of the CBS inhibitor AOAA were characterized. It was found that AOAA can be replaced by serine, which allows for the continuation of the catalytic cycle. Serine rescued the activity and function of AOAA-inhibited CBS. The results demonstrate the complexity of using AOAA as a CBS inhibitor and highlight the need for a potent, selective, and specific pharmacological CBS inhibitor.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Tomas Majtan, Viktor Kozich, Warren D. Kruger
Summary: Homocystinuria, a common metabolic disorder, is characterized by increased homocysteine levels, leading to various clinical complications. Current treatment primarily involves dietary interventions, but alternative therapies such as enzyme and gene therapies have been explored.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Renata Collard, Tomas Majtan
Summary: Homocystinuria is an inherited metabolic disorder caused by lack of cystathionine beta-synthase (CBS) activity. This study found that pathogenic CBS variants result in dysregulation of gene expression of small heat shock proteins and HSP40 family members, as well as endoplasmic reticulum stress and protein degradation. Manipulation of cellular proteostasis could rescue CBS variant function and potentially serve as a therapeutic approach for treating HCU.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Erez M. Bublil, Tomas Majtan
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
