Enzymology of H2S Biogenesis, Decay and Signaling

Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase

(2012) Iori Ueki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

High Turnover Rates for Hydrogen Sulfide Allow for Rapid Regulation of Its Tissue Concentrations

(2012) Victor Vitvitsky et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Sulfide:Quinone Oxidoreductase Catalyzes the First Step in Hydrogen Sulfide Metabolism and Produces a Sulfane Sulfur Metabolite

(2012) Michael R. Jackson et al.   BIOCHEMISTRY

Distribution of hydrogen sulfide (H2S)-producing enzymes and the roles of the H2S donor sodium hydrosulfide in diabetic nephropathy

(2012) Junichiro Yamamoto et al.   Clinical and Experimental Nephrology

Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase

(2012) Jeffrey G. Dickhout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Patient Mutations in Human Persulfide Dioxygenase (ETHE1) Involved in H2S Catabolism

(2012) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–activity characterization of sulfide:quinone oxidoreductase variants

(2012) Maia M. Cherney et al.   JOURNAL OF STRUCTURAL BIOLOGY

Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols

(2012) Milos R. Filipovic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

(2012) T. Morikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues

(2011) Omer Kabil et al.   ANTIOXIDANTS & REDOX SIGNALING

Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells

(2011) Dominika Sliwa et al.   BIOCHEMICAL JOURNAL

Reversible Heme-Dependent Regulation of Human Cystathionine β-Synthase by a Flavoprotein Oxidoreductase

(2011) Omer Kabil et al.   BIOCHEMISTRY

Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

(2011) Asif K. Mustafa et al.   CIRCULATION RESEARCH

Taurine Biosynthesis by Neurons and Astrocytes

(2011) Victor Vitvitsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Free and Acid-Labile Hydrogen Sulfide Concentrations in Mouse Tissues: Anomalously High Free Hydrogen Sulfide in Aortic Tissue

(2010) Michael D. Levitt et al.   ANTIOXIDANTS & REDOX SIGNALING

Rapid Reaction of Hydrogen Sulfide with the Neutrophil Oxidant Hypochlorous Acid to Generate Polysulfides

(2010) Péter Nagy et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxygen Activation at Mononuclear Nonheme Iron Centers: A Superoxo Perspective

(2010) Anusree Mukherjee et al.   INORGANIC CHEMISTRY

Redox Biochemistry of Hydrogen Sulfide

(2010) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Sulfide:Quinone Oxidoreductase from Acidithiobacillus ferrooxidans: Insights into Sulfidotrophic Respiration and Detoxification

(2010) Maia M. Cherney et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Functional Insights into Sulfide:Quinone Oxidoreductase,

(2009) José A. Brito et al.   BIOCHEMISTRY

Vascular Endothelium Expresses 3-Mercaptopyruvate Sulfurtransferase and Produces Hydrogen Sulfide

(2009) N. Shibuya et al.   JOURNAL OF BIOCHEMISTRY

H2S Biogenesis by Human Cystathionine γ-Lyase Leads to the Novel Sulfur Metabolites Lanthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia

(2009) Taurai Chiku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions

(2009) Sangita Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mercaptopyruvate Sulfurtransferase ofTrichomonas vaginalisLinks Cysteine Catabolism to the Production of Thioredoxin Persulfide

(2009) Gareth D. Westrop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of the heme electronic structure and cystathionine β-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation

(2009) Sangita Singh et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy

(2009) Valeria Tiranti et al.   NATURE MEDICINE

The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respiration

(2009) M. Marcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values

(2008) Julie Furne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

(2008) Norihiro Shibuya et al.   ANTIOXIDANTS & REDOX SIGNALING

A Source of Hydrogen Sulfide and a Mechanism of Its Release in the Brain

(2008) Mari Ishigami et al.   ANTIOXIDANTS & REDOX SIGNALING

Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria

(2008) Tatjana M. Hildebrandt et al.   FEBS Journal

Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats

(2008) Lingyun Wu et al.   LABORATORY INVESTIGATION

Human Polycomb 2 Protein Is a SUMO E3 Ligase and Alleviates Substrate-Induced Inhibition of Cystathionine β-Synthase Sumoylation

(2008) Nitish Agrawal et al.   PLoS One

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE