Article
Chemistry, Medicinal
Zhiyuan Chen, Ran Ke, Zhiqiang Song, Yang Zhou, Xiaomei Ren, Weixue Huang, Zhen Wang, Ke Ding
Summary: Photoinduced drug release is a promising strategy for precise cancer therapy. The newly designed photocaged B-RafV600E inhibitor 2 can release active drugs under UV irradiation, effectively inhibiting the proliferation of melanoma cells and showing similar effects under sunlight exposure.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Oncology
Pui-Kei Wu, Seung-Keun Hong, Jong-In Park
Summary: The study found that RNA interference of mortalin can induce cell death in vemurafenib-resistant B-Raf mutant melanoma cells, and chemical inhibition of MEK1/2 and ERK1/2 can suppress mortalin depletion-induced death. Therefore, mortalin may serve as a potential therapeutic target for BRAFi-resistant BRAF mutant tumors.
Article
Multidisciplinary Sciences
Wenping Zhou, Wenxue Li, Shisheng Wang, Barbora Salovska, Zhenyi Hu, Bo Tao, Yi Di, Ujwal Punyamurtula, Benjamin E. E. Turk, William C. C. Sessa, Yansheng Liu
Summary: The authors used optogenetics and mass spectrometry-based phosphoproteomics to study the effects of different intensities, durations, and patterns of Akt1 activation on phosphorylation circuits, revealing downstream signaling outcomes of Akt1. The study showed that different intensities, durations, and patterns of Akt1 activation lead to distinct phosphorylation profiles in vascular endothelial cells, and also revealed the interaction between Akt1 signaling and growth factor signaling in these cells. The resulting dataset provides an important resource for future studies on AKT signaling and dynamics.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Shirley Tong, Shaban Darwish, Hanieh Hossein Nejad Ariani, Kate Alison Lozada, David Salehi, Maris A. Cinelli, Richard B. Silverman, Kamaljit Kaur, Sun Yang
Summary: This study demonstrates the potential of using KK-11 peptide to enhance drug delivery to melanoma cells, showing promising results in both in vitro and in vivo experiments. The findings have important implications for the development of targeted therapies for human melanoma.
Article
Oncology
Keshava K. Datta, Parthiban Periasamy, Sonali V. Mohan, Rebekah Ziegman, Harsha Gowda
Summary: The study identified mechanisms by which cancer cells adapt and survive in oxygen-poor environments, providing novel avenues for treatment. Cancer cells in hypoxic environments are resistant to chemotherapy and radiation, and identifying proteins and pathways regulating their survival could improve anticancer therapy efficacy. The study's proteomic profiling revealed metabolic reprogramming and novel phosphorylation changes, indicating potential vulnerabilities that can be targeted for therapeutic purposes.
Article
Oncology
Laurence Booth, Cameron West, Daniel Von Hoff, John M. Kirkwood, Paul Dent
Summary: The study revealed a lethal interaction between GZ17-6.02 and the MEK1/2 inhibitor trametinib and the B-RAF inhibitor dabrafenib, showing potential in killing melanoma cells and impacting multiple signaling pathways differently.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kevin Yao, Emily Zhou, Chao Cheng
Summary: In this study, a B-Raf signature score was defined using RNA-seq data, which could predict B-Raf mutation status and other aberrations. Patients dichotomized by the median B-Raf score showed more significant stratification compared to other metrics. High B-Raf score also predicted higher sensitivity to B-Raf inhibitors and drugs targeting other relevant oncogenic pathways.
Article
Oncology
Thomas Gruber, Steve Robatel, Mirela Kremenovic, Lukas Bariswyl, Jurg Gertsch, Mirjam Schenk
Summary: The study highlights the critical role of CB2R in regulating tumor immunity in melanoma, with high CB2R gene expression associated with improved overall survival. Mouse models and in-depth analysis of tumor-infiltrating lymphocytes suggest that CB2R deficiency may lead to an immunosuppressive microenvironment by affecting B cell differentiation. This insight could potentially inform the development of novel CB2R-targeted cancer therapies.
Article
Biochemistry & Molecular Biology
Joong-Seok Woo, Eun-Seon Yoo, Sung-Hyun Kim, Jae-Han Lee, So-Hee Han, Soo-Hyun Jung, Gi-Hwan Jung, Ji-Youn Jung
Summary: OA treatment leads to induction of apoptosis in melanoma cells through increased apoptotic bodies and decreased expression of antiapoptotic proteins such as Bcl-2.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Cathleen Haase-Kohn, Markus Laube, Cornelius K. Donat, Birgit Belter, Jens Pietzsch
Summary: The inducible isoenzyme cyclooxygenase-2 (COX-2) plays a crucial role in cellular signaling and tumor progression. Knockout of COX-2 in melanoma cells significantly reduces invasion, colony and spheroid formation potential, and tumor development. COX-2 knockout also alters cellular metabolic activity and downstream signaling pathways that are closely related to cancer metastasis. Targeted suppression of COX-2, combined with modulation of related signaling pathways, shows promise as a therapeutic approach for melanoma.
Article
Chemistry, Organic
Tyler Fahrenhorst-Jones, Dehui Kong, Jed M. Burns, Gregory K. Pierens, Paul V. Bernhardt, G. Paul Savage, Craig M. Williams
Summary: It is found that seco-1-Azacubane-2-carboxylic acid can undergo amide bond formation at both the N- and C-termini using proline-based bioactive molecule templates as a concept platform.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Oncology
Inna Smalley, Zhihua Chen, Manali Phadke, Jiannong Li, Xiaoqing Yu, Clayton Wyatt, Brittany Evernden, Jane L. Messina, Amod Sarnaik, Vernon K. Sondak, Chaomei Zhang, Vincent Law, Nam Tran, Arnold Etame, Robert J. B. Macaulay, Zeynep Eroglu, Peter A. Forsyth, Paulo C. Rodriguez, Y. Ann Chen, Keiran S. M. Smalley
Summary: This study used single-cell RNA sequencing to define the immune landscape of melanoma CNS metastases in different sites. The results showed that immune environment in LMM was distinct from MBM and skin metastases, and therapy in MBM patients led to increased immune infiltrate.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Hansol Lee, Ines Pires Da Silva, Umaimainthan Palendira, Richard A. Scolyer, Georgina V. Long, James S. Wilmott
Summary: NK cells play a crucial role in the innate immune system and can enhance adaptive immune responses. The activation of NK cells is regulated by a balance of inhibitory and activating receptors. These cells are potent producers of proinflammatory cytokines and can elicit strong antitumor responses through secretion of perforin and granzyme B. Strategies to enhance NK cell responses are being evaluated in clinical trials to improve immunotherapy effectiveness.
Article
Genetics & Heredity
Stephanie Jonuscheit, Tina Jost, Fritzi Gajdosova, Maximilian Wrobel, Markus Hecht, Rainer Fietkau, Luitpold Distel
Summary: Niraparib and Talazoparib, as PARP 1/2 inhibitors, sensitize melanoma cells to ionizing radiation (IR), with healthy tissue being less affected. However, the heterogeneity of results suggests the need for prior testing of tumor cells for personalized treatment.
Article
Multidisciplinary Sciences
Thibault Houles, Genevieve Lavoie, Sami Nourreddine, Winnie Cheung, Eric Vaillancourt-Jean, Celia M. Guerin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux
Summary: The study reveals the regulation of CDK12 activity by the RAS/MAPK pathway in melanoma, highlighting the potential of CDK12 inhibitors in combination with other pathways to suppress melanoma growth. Increased CDK12 activity in melanoma cells leads to higher expression of DNA repair genes, while its inhibition promotes the expression of genes associated with growth promotion.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Vladimir A. Volkov, Paula M. Grissom, Vladimir K. Arzhanik, Anatoly V. Zaytsev, Kutralanathan Renganathan, Tristan McClure-Begley, William M. Old, Natalie Ahn, J. Richard McIntosh
JOURNAL OF CELL BIOLOGY
(2015)
Correction
Biochemical Research Methods
Robert Brown, Scott A. Stuart, Stephane Houel, Natalie G. Ahn, William M. Old
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2015)
Article
Biochemical Research Methods
Robert Brown, Scott S. Stuart, Stephane Houel, Natalie G. Ahn, William M. Old
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2015)
Article
Cell Biology
Jun Long, Robert Tokhunts, William M. Old, Stephane Houel, Jezabel Rodgriguez-Blanco, Samer Singh, Neal Schilling, Anthony J. Capobianco, Natalie G. Ahn, David J. Robbins
Article
Biochemistry & Molecular Biology
Laura J. Marholz, Le Chang, William M. Old, Xiang Wang
ACS CHEMICAL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Erin A. Peden, Marko Boehm, David W. Mulder, ReAnna Davis, William M. Old, Paul W. King, Maria L. Ghirardi, Alexandra Dubini
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Dermatology
Sudeshna M. Chatterjea, Katheryn A. Resing, William Old, Wilas Nirunsuksiri, Philip Fleckman
JOURNAL OF DERMATOLOGICAL SCIENCE
(2011)
Article
Biochemistry & Molecular Biology
Steven L. Ponicsan, Stephane Houel, William M. Old, Natalie G. Ahn, James A. Goodrich, Jennifer F. Kugel
JOURNAL OF MOLECULAR BIOLOGY
(2013)
Article
Chemistry, Physical
Charles M. Nichols, William M. Old, W. Carl Lineberger, Veronica M. Bierbaum
JOURNAL OF PHYSICAL CHEMISTRY A
(2015)
Article
Biochemical Research Methods
Venkataramanan Subramanian, Alexandra Dubini, David P. Astling, Lieve M. L. Laurens, William M. Old, Arthur R. Grossman, Matthew C. Posewitz, Michael Seibert
JOURNAL OF PROTEOME RESEARCH
(2014)
Article
Biochemical Research Methods
Thomas Lee, Nan Wang, Stephane Houel, Kasey Couts, William Old, Natalie Ahn
MOLECULAR & CELLULAR PROTEOMICS
(2015)
Article
Genetics & Heredity
Jennifer S. Avena, Shannon Burns, Zulin Yu, Christopher C. Ebmeier, William M. Old, Sue L. Jaspersen, Mark Winey
Article
Multidisciplinary Sciences
Steven E. Guard, Zachary C. Poss, Christopher C. Ebmeier, Maria Pagratis, Helen Simpson, Dylan J. Taatjes, William M. Old
SCIENTIFIC REPORTS
(2019)
Article
Biology
Kerri A. Ball, Kristofor J. Webb, Stephen J. Coleman, Kira A. Cozzolino, Jeremy Jacobsen, Kevin R. Jones, Michael H. B. Stowell, William M. Old
COMMUNICATIONS BIOLOGY
(2020)