Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase

(2018) Tomas Majtan et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulators of the Transsulfuration Pathway

(2018) Juan I Sbodio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemoresistance in ovarian cancer: exploiting cancer stem cell metabolism

(2018) Shan-Shan Li et al.   Journal of Gynecologic Oncology

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

(2017) Takeo Goji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

(2017) Ilaria Marrocco et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanical Ventilation Augments Poly(I:C)-Induced Lung Injury via a WISP1-Integrin β3-Dependent Pathway in Mice

(2016) Shuqing Jin et al.   MOLECULAR MEDICINE

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

The Effects of Sequence Variation on Genome-wide NRF2 Binding—New Target Genes and Regulatory SNPs

(2016) Suvi M. Kuosmanen et al.   NUCLEIC ACIDS RESEARCH

Chemoresistance and targeted therapies in ovarian and endometrial cancers

(2016) Kevin Brasseur et al.   Oncotarget

Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement

(2015) Kenneth Hensley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer

(2015) Prabir K Chakraborty et al.   Oncotarget

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance

(2013) Sanjib Bhattacharyya et al.   PLoS One

Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

(2013) R. d'Emmanuele di Villa Bianca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Sildenafil Effect on the Human Bladder Involves the L-cysteine/Hydrogen Sulfide Pathway: A Novel Mechanism of Action of Phosphodiesterase Type 5 Inhibitors

(2012) Ferdinando Fusco et al.   EUROPEAN UROLOGY

The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

(2011) Gethin J. McBean   AMINO ACIDS

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress

(2010) Shawn E. Bearden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research

(2010) Richard S. Beard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions

(2009) Sangita Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystathionine γ-lyase: Clinical, metabolic, genetic, and structural studies

(2009) Jan P. Kraus et al.   MOLECULAR GENETICS AND METABOLISM

Hydrogen Sulfide Scavenges the Cytotoxic Lipid Oxidation Product 4-HNE

(2009) Sabine M. Schreier et al.   NEUROTOXICITY RESEARCH