Flavonoid‐Derived Human Phenyl‐γ‐Valerolactone Metabolites Selectively Detoxify Amyloid‐β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Thousands of amyloids may foil Alzheimer’s drugs

(2019) John Hodgson   NATURE BIOTECHNOLOGY

Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites

(2019) Monira Pervin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models

(2019) Donato Angelino et al.   Nutrients

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

(2019) Zahra Najarzadeh et al.   Biomolecules

The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice

(2018) Giulio Maria Pasinetti et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease, Oligomers, and Inflammation

(2018) Gianluigi Forloni et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation

(2018) Baptiste N. Jaeger et al.   MOLECULAR ASPECTS OF MEDICINE

Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings

(2018) Gina Borges et al.   MOLECULAR ASPECTS OF MEDICINE

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models

(2018) Claudia Balducci et al.   NEUROBIOLOGY OF AGING

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies

(2018) Javier I. Ottaviani et al.   Scientific Reports

5-(3′,4′-Dihydroxyphenyl-γ-valerolactone), a Major Microbial Metabolite of Proanthocyanidin, Attenuates THP-1 Monocyte-Endothelial Adhesion

(2017) Charles C. Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood-Brain Barrier Permeability of Green Tea Catechin Metabolites and their Neuritogenic Activity in Human Neuroblastoma SH-SY5Y Cells

(2017) Keiko Unno et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Synthetic and analytical strategies for the quantification of phenyl-γ-valerolactone conjugated metabolites in human urine

(2017) Nicoletta Brindani et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Clioquinol Decreases Amyloid-β Burden and Reduces Working Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Cristina Grossi et al.   JOURNAL OF ALZHEIMERS DISEASE

An Oral Aβ Vaccine Using a Recombinant Adeno-Associated Virus Vector in Aged Monkeys: Reduction in Plaque Amyloid and Increase in Aβ Oligomers

(2016) Hideo Hara et al.   JOURNAL OF ALZHEIMERS DISEASE

Chocolate Consumption is Associated with a Lower Risk of Cognitive Decline

(2016) Afonso Moreira et al.   JOURNAL OF ALZHEIMERS DISEASE

The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives

(2016) Javier I. Ottaviani et al.   Scientific Reports

Catalytic, Enantioselective Vinylogous Mukaiyama Aldol Reaction of Furan-Based Dienoxy Silanes: A Chemodivergent Approach to γ-Valerolactone Flavan-3-ol Metabolites and δ-Lactone Analogues

(2015) Claudio Curti et al.   ADVANCED SYNTHESIS & CATALYSIS

Stabilization of Nontoxic A -Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease

(2015) T. M. Ryan et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

(2015) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization

(2015) Dongjie Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Peculiar Role of the A2V Mutation in Amyloid-β (Aβ) 1–42 Molecular Assembly

(2014) Massimo Messa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults

(2014) Adam M Brickman et al.   NATURE NEUROSCIENCE

Clioquinol promotes the degradation of metal-dependent amyloid-  (A ) oligomers to restore endocytosis and ameliorate A  toxicity

(2014) K. E. S. Matlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein aggregation propensity is a crucial determinant of intracellular inclusion formation and quality control degradation

(2013) Anna Villar-Piqué et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The neuroprotective effects of cocoa flavanol and its influence on cognitive performance

(2012) Astrid Nehlig   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A yeast model for amyloid-  aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity

(2012) F. D'Angelo et al.   Disease Models & Mechanisms

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

(2012) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Potential protection of green tea polyphenols against intracellular amyloid beta-induced toxicity on primary cultured prefrontal cortical neurons of rats

(2012) Xiao-Yan Qin et al.   NEUROSCIENCE LETTERS

Antioxidative Activity of Microbial Metabolites of (−)-Epigallocatechin Gallate Produced in Rat Intestines

(2011) Akiko TAKAGAKI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Polyphenolic Glycosides and Aglycones Utilize Opposing Pathways To Selectively Remodel and Inactivate Toxic Oligomers of Amyloid β

(2011) Ali Reza A. Ladiwala et al.   CHEMBIOCHEM

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)1–40 and Aβ1–42 from the corresponding depsipeptides

(2010) Marten Beeg et al.   ANALYTICAL BIOCHEMISTRY

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

(2010) Vikram Khurana et al.   NATURE REVIEWS NEUROSCIENCE

Bioavailability and catabolism of green tea flavan-3-ols in humans

(2010) Daniele Del Rio et al.   NUTRITION

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clioquinol and other hydroxyquinoline derivatives inhibit Aβ(1–42) oligomer assembly

(2009) Harry LeVine et al.   NEUROSCIENCE LETTERS

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON