The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

Vitamin C Restores Behavioral Deficits and Amyloid-β Oligomerization without Affecting Plaque Formation in a Mouse Model of Alzheimer's Disease

(2018) Kazuma Murakami et al.   JOURNAL OF ALZHEIMERS DISEASE

Soluble Oligomers of Amyloid-β Cause Changes in Redox State, DNA Methylation, and Gene Transcription by Inhibiting EAAT3 Mediated Cysteine Uptake

(2018) Nathaniel Hodgson et al.   JOURNAL OF ALZHEIMERS DISEASE

Cellular Prion Protein as a Therapeutic Target in Alzheimer's Disease

(2018) Juha Laurén   JOURNAL OF ALZHEIMERS DISEASE

Rapid, Reversible Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Amyloid-β

(2018) Sangmook Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

The Mitochondrial Secret(ase) of Alzheimer's Disease

(2017) Kisha J. Young et al.   JOURNAL OF ALZHEIMERS DISEASE

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation

(2014) Peng-xin Xu et al.   BEHAVIOURAL BRAIN RESEARCH

Immunotherapy for Alzheimer's disease

(2014) Thomas Wisniewski et al.   BIOCHEMICAL PHARMACOLOGY

Tau acts as a mediator for Alzheimer's disease-related synaptic deficits

(2014) Dezhi Liao et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits

(2014) Eric C. Miller et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Dysfunction in Alzheimer’s Disease

(2014) Jie-Qiong Li et al.   MOLECULAR NEUROBIOLOGY

Axonal Transport Defects in Alzheimer’s Disease

(2014) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism

(2013) Karin E. Sandoval et al.   BRAIN RESEARCH

Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012)

(2013) Federica Belluti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicityin Vivo

(2013) Brian R. Fluharty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-  signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

(2013) M. E. Seward et al.   JOURNAL OF CELL SCIENCE

Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer's disease model by modulating BDNF signaling pathway

(2013) Annamaria Cimini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Alzheimer's Disease Related Markers, Cellular Toxicity and Behavioral Deficits Induced Six Weeks after Oligomeric Amyloid-β Peptide Injection in Rats

(2013) Charleine Zussy et al.   PLoS One

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Correlation of Specific Amyloid-β Oligomers With Tau in Cerebrospinal Fluid From Cognitively Normal Older Adults

(2013) Maureen Handoko et al.   JAMA Neurology

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca2+ via InsP3R-dependent and -independent mechanisms

(2013) Laura E. Jensen et al.   Frontiers in Molecular Neuroscience

Isolated Amyloid-β(1–42) Protofibrils, But Not Isolated Fibrils, Are Robust Stimulators of Microglia

(2012) Geeta S. Paranjape et al.   ACS Chemical Neuroscience

Pittsburgh compound B and the postmortem diagnosis of alzheimer disease

(2012) Dana M. Niedowicz et al.   ANNALS OF NEUROLOGY

Soluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response

(2012) Yan He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunotherapy for Alzheimer’s disease: from anti-β-amyloid to tau-based immunization strategies

(2012) Francesco Panza et al.   Immunotherapy

Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-β at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3β Signaling Pathway

(2012) Takayoshi Tokutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Choline Acetyltransferase as a Mechanism for Cholinergic Dysfunction Induced by Amyloid-β Peptide Oligomers

(2012) Nilson Nunes-Tavares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in insulin-signaling transduction pathway underlie learning/memory deficits in an Alzheimer’s disease rat model

(2012) Xiaojuan Han et al.   JOURNAL OF NEURAL TRANSMISSION

Different effects of soluble and aggregated amyloid β42 on gene/protein expression and enzyme activity involved in insulin and APP pathways

(2012) Jasmin Bartl et al.   JOURNAL OF NEURAL TRANSMISSION

Stable Size Distribution of Amyloid Plaques Over the Course of Alzheimer Disease

(2012) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

(2012) Zhiyou Cai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Orally bioavailable small molecule drug protects memory in Alzheimer's disease models

(2012) Eugene O'Hare et al.   NEUROBIOLOGY OF AGING

Amyloid-β Protein Modulates Insulin Signaling in Presynaptic Terminals

(2012) David Heras-Sandoval et al.   NEUROCHEMICAL RESEARCH

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

(2012) Maj-Linda B. Selenica et al.   Neurodegenerative Diseases

Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity

(2012) Pradeep Dewapriya et al.   NEUROTOXICOLOGY

A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

(2012) H. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early and Selective Impairments in Axonal Transport Kinetics of Synaptic Cargoes Induced by Soluble Amyloid β-Protein Oligomers

(2012) Yong Tang et al.   TRAFFIC

Inhibition of AMPA receptor trafficking at hippocampal synapses by β-amyloid oligomers: the mitochondrial contribution

(2012) Yanfang Rui et al.   Molecular Brain

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

(2011) Giovanna Cenini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Estrogen-induced signaling attenuates soluble Aβ peptide-mediated dysfunction of pathways in synaptic plasticity

(2011) Shaun M. Logan et al.   BRAIN RESEARCH

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

(2011) Dong-Young Choi et al.   BRAIN RESEARCH BULLETIN

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

(2011) Bruno P Imbimbo et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Soluble Oligomers of Amyloid-β Peptide Disrupt Membrane Trafficking of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Contributing to Early Synapse Dysfunction

(2011) Alfredo J. Miñano-Molina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins

(2011) Clive Bate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

(2011) Kazuma Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-channel Ca2+imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

(2011) Angelo Demuro et al.   JOURNAL OF CELL BIOLOGY

Low-n oligomers as therapeutic targets of Alzheimer’s disease

(2011) Kenjiro Ono et al.   JOURNAL OF NEUROCHEMISTRY

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

(2011) Bibiana DaRocha-Souto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

(2011) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Anesthetic Propofol Attenuates the Isoflurane-Induced Caspase-3 Activation and Aβ Oligomerization

(2011) Yiying Zhang et al.   PLoS One

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

The history of the cholinergic hypothesis

(2010) Antonio Contestabile   BEHAVIOURAL BRAIN RESEARCH

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

DMXB (GTS-21) ameliorates the cognitive deficits in beta amyloid25-35−injected mice through preventing the dysfunction of alpha7 nicotinic receptor

(2010) Lei Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

(2010) Young-Don Kwak et al.   Molecular Neurodegeneration

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Calcium Signalling and Alzheimer’s Disease

(2010) Michael J. Berridge   NEUROCHEMICAL RESEARCH

H2O2 and PAF mediate Aβ1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761

(2010) Chun Shi et al.   NEUROCHEMISTRY INTERNATIONAL

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Formulation of a Medical Food Cocktail for Alzheimer's Disease: Beneficial Effects on Cognition and Neuropathology in a Mouse Model of the Disease

(2010) Anna Parachikova et al.   PLoS One

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-beta Leads to Impaired Cellular Respiration, Energy Production and Mitochondrial Electron Chain Complex Activities in Human Neuroblastoma Cells

(2009) V. Rhein et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Disease-Modifying Approach to the Treatment of Alzheimerʼs Disease

(2009) Francesco Panza et al.   DRUGS & AGING

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

(2009) Zhenglin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

(2009) S. D. Buckingham et al.   PHARMACOLOGICAL REVIEWS

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans

(2009) Siler H. Panowski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

(2008) Lindsay C. Reese et al.   AGING CELL

Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin

(2008) Masafumi Sakono et al.   FEBS Journal

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation

(2008) Kohei Yuyama et al.   JOURNAL OF NEUROCHEMISTRY

ER stress is involved in Aβ‐induced GSK‐3β activation and tau phosphorylation

(2008) Rosa Resende et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid-β immunisation for Alzheimer's disease

(2008) Thomas Wisniewski et al.   LANCET NEUROLOGY

Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

(2008) T Chiba et al.   MOLECULAR PSYCHIATRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

β-Amyloid Oligomers Affect the Structure and Function of the Postsynaptic Region: Role of the Wnt Signaling Pathway

(2008) Margarita C. Dinamarca et al.   Neurodegenerative Diseases

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

(2008) R. Resende et al.   NEUROSCIENCE

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE