Article
Medicine, Research & Experimental
Onur Cil, Peter M. Haggie, Joseph-Anthony Tapia Tan, Amber A. Rivera, Alan S. Verkman
Summary: Functional evidence suggests complementary and region-specific roles of PAT1 and DRA in intestinal fluid absorption, with PAT1 as the predominant anion exchanger in mouse ileum. The compound PAT1(inh)-B01 is considered a novel tool for studying intestinal ion and fluid transport and potentially a drug candidate for small intestinal hyposecretory disorders.
Article
Biochemistry & Molecular Biology
Chorlada Paiboonrungruang, Zhaohui Xiong, David Lamson, Yahui Li, Brittany Bowman, Julius Chembo, Caizhi Huang, Jianying Li, Eric W. Livingston, Jon E. Frank, Vivian Chen, Yong Li, Bernard Weissman, Hong Yuan, Kevin P. Williams, M. Ben Major, Xiaoxin Chen
Summary: This study identified and validated pyrimethamine as an NRF2 inhibitor that can effectively suppress NRF2 overexpression in esophageal squamous cell carcinoma (ESCC) and showed promising results in a genetically modified mouse model.
Article
Microbiology
Mohamed Belal Hamed, Ewa Burchacka, Liselotte Angus, Arnaud Marchand, Jozefien De Geyter, Maria S. Loos, Jozef Anne, Hugo Klaassen, Patrick Chaltin, Spyridoula Karamanou, Anastassios Economou
Summary: The study identified 14 secretion inhibitors with potential antibacterial activity through high-throughput screening, some of which demonstrated bactericidal effects against both Gram-negative and Gram-positive bacteria. These results provide evidence for the development of potential antibiotics starting compounds.
Article
Cell Biology
Triana Amen, Daniel Kaganovich
Summary: Metabolic regulation is essential for stress response pathways, and the interconnection between stress granule formation and lipid droplet accumulation has been uncovered, revealing a novel relationship between stress adaptation mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Qi Cui, Gustavo Garcia, Mingzi Zhang, Cheng Wang, Hongzhi Li, Tao Zhou, Guihua Sun, Vaithilingaraja Arumugaswami, Yanhong Shi
Summary: The study identified a small molecule compound, Q34, that can efficiently block the cellular entry of SARS-CoV-2 into human cells and has a favorable safety profile, showing potential as prophylactics and therapeutics for COVID-19 and future pandemics.
Article
Multidisciplinary Sciences
Andres Andrade-Dominguez, Abigail Trejo-Hernandez, Carmen Vargas-Lagunas, Sergio Encarnacion-Guevara
Summary: The study found that the fungus promotes the growth of the bacterium and that together, these organisms form a mixed biofilm whose biomass is about 3 times greater and more structured than that of either single-species biofilm. Additionally, the study showed that the biofilm traits are dependent on a symbiotic plasmid encoding elements involved in the phenotypic plasticity of the bacterium, mitochondrial function, and in the production of a yeast-secreted sophoroside.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Miquel Navarro, Juan Jose Moreno, Marina Perez-Jimenez, Jesus Campos
Summary: There is a growing interest in bimetallic cooperative complexes for their potential in bond activation and catalysis. This field takes inspiration from metalloenzymes in nature and heterogeneous catalysis. Combining two metals in close proximity offers a wide range of opportunities, regardless of the presence of M-M interactions. The choice of metal pairs is crucial for the reactivity of the resulting complexes, including not only transition metals but also main group series, which provide additional pathways for cooperative pathways and reaction discovery. The precise synergy between the two metal atoms enables bond activation across bimetallic structures. The results discussed here indicate a promising future for the design of efficient catalytic processes and the discovery of new catalytic transformations through bimetallic synergism.
CHEMICAL COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Francesca Rapino, Ted Natoli, Francesco Limone, Erin O'Connor, Jack Blank, Matthew Tegtmeyer, William Chen, Erika Norabuena, Juhi Narula, Dane Hazelbaker, Gabriella Angelini, Lindy Barrett, Alison O'Neil, Ursula K. Beattie, Jessica M. Thanos, Heather de Rivera, Steven D. Sheridan, Roy H. Perlis, Steven A. McCarroll, Beth Stevens, Aravind Subramanian, Ralda Nehme, Lee L. Rubin
Summary: In the brain, the complement system is important in the immune response and synaptic elimination. This study identified pathways that regulate the production of complement component 4 (C4), linked to increased schizophrenia risk. A 3D protocol was developed to produce astrocytes, and a small-molecule screen identified regulators of C4 secretion. Additional regulatory pathways were predicted and validated, including one involving c-Jun-kinase. This research lays the foundation for developing therapies targeting the complement cascade in CNS diseases.
Article
Chemistry, Multidisciplinary
Antonio Carone, Pablo Mariani, Anthony Desert, Marco Romanelli, Jacopo Marcheselli, Marco Garavelli, Stefano Corni, Ivan Rivalta, Stephane Parola
Summary: Chiral plasmonic nanomaterials have promising applications. This study expands the range of available chiral plasmonic nanostructures and proposes the importance of the outer part of the nanoparticles shell on plasmonic circular dichroism.
Article
Multidisciplinary Sciences
Guodong Li, Chung-Nga Ko, Dan Li, Chao Yang, Wanhe Wang, Guan-Jun Yang, Carmelo Di Primo, Vincent Kam Wai Wong, Yaozu Xiang, Ligen Lin, Dik-Lung Ma, Chung-Hang Leung
Summary: This study reports the design and synthesis of a small molecule stabilizer of HIF-1 alpha, which promotes wound healing in diabetic patients according to experiments in mouse models. The compound accelerates wound closure in both normal and diabetic mice, with a greater effect observed in diabetic mice, indicating its potential as a therapeutic agent for diabetic wounds.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Hossein Adelnia, Fariba Sirous, Idriss Blakey, Hang Thu Ta
Summary: Poly(aspartic acid) (PASP) is a biodegradable, biocompatible water-soluble synthetic anionic polypeptide that can chelate with heavy and alkaline earth metal ions. PASP has been utilized as a scale inhibitor in industries due to its calcium chelation ability, as a stabilizer for wine preservation due to its potassium chelation ability, and as a corrosion inhibitor for steel surfaces in harsh environments due to its iron chelation ability. PASP also has potential applications in enhancing the stability of colloidal systems and mitigating the toxicity of heavy metals.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Julien Roy Ishibashi, Riya Keshri, Tommy Henry Taslim, Daniel Kennedy Brewer, Tung Ching Chan, Scott Lyons, Anika Marie McManamen, Ashley Chen, Debra Del Castillo, Hannele Ruohola-Baker
Summary: This study utilized a genetically tractable model for stem cell survival in Drosophila gonads to identify small molecule drug candidates that may sensitize cancer stem cells to apoptosis, uncovering the NF-kappa B pathway as essential in GSC quiescence and viability. The study highlights the potential of the Drosophila stem cell niche as a model system for targeted drug discovery.
Review
Materials Science, Multidisciplinary
Bin Kan, Yuanyuan Kan, Lijian Zuo, Xueliang Shi, Ke Gao
Summary: Recent breakthroughs have been made in solution-processed organic solar cells combining small-molecule donor and nonfullerene acceptor, with certified efficiency over 15%. By modifying materials and optimizing morphology, researchers have achieved impressive progress in this area. Small-molecule materials with easily tuned properties will be a key focus for future developments.
Review
Chemistry, Inorganic & Nuclear
Ashta C. Ghosh, Carole Duboc, Marcello Gennari
Summary: Transition metal-driven small molecule activation is essential for the production of fuels and chemicals or energy supply. The use of multimetallic catalysts, where two or more metal centers act in synergy to activate and transform the substrate(s), is widespread both in nature (metalloenzymes) and (bio)inorganic chemistry. Benefits of this strategy in terms of catalytic performances result from cooperation between different metals to bind and activate a single substrate, to activate different substrates reacting together, or with one assisting metal tuning the reactivity of the active metal center.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Inorganic & Nuclear
Mahendra Kumar Awasthi, S. K. Tarik Aziz, Abhishek Saini, Goutam K. Lahiri, Arnab Dutta
Summary: This article discusses the development of bifunctional catalysts for the conversion of renewable energy into chemical energy. These catalysts play a key role in the H2 production/water oxidation and O2 reduction/water oxidation reactions. By modulating the surface morphology of the catalysts, active heterogeneous bifunctional catalysts can be developed, providing a foundation for efficient and sustainable energy usage and storage.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Multidisciplinary Sciences
J. Brucker Nourse, Gilad Harshefi, Adi Marom, Abdelrahaman Karmi, Hagit Cohen Ben-Ami, Kim A. Caldwell, Guy A. Caldwell, Millet Treinin
Summary: Tobacco-derived nicotine selectively protects dopaminergic neurons by activating nicotinic acetylcholine receptors, involving conserved functions of various genes and pathways, such as calcium modulation, mitochondrial stress, and cytoplasmic quality control.
Article
Medicine, Research & Experimental
Reini E. N. van der Welle, Rebekah Jobling, Christian Burns, Paolo Sanza, Jan A. van der Beek, Alfonso Fasano, Lan Chen, Fried J. Zwartkruis, Susan Zwakenberg, Edward F. Griffin, Corlinda ten Brink, Tineke Veenendaal, Nalan Liv, Conny M. A. van Ravenswaaij-Arts, Henny H. Lemmink, Rolph Pfundt, Susan Blaser, Carolina Sepulveda, Andres M. Lozano, Grace Yoon, Teresa Santiago-Sim, Cedric S. Asensio, Guy A. Caldwell, Kim A. Caldwell, David Chitayat, Judith Klumperman
Summary: Mutations in VPS41 disrupt HOPS function, interfere with the TFEB/TFE3 axis of mTORC1 signaling, and result in a neurodegenerative disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Chenglong Xie, Xu-Xu Zhuang, Zhangming Niu, Ruixue Ai, Sofie Lautrup, Shuangjia Zheng, Yinghui Jiang, Ruiyu Han, Tanima Sen Gupta, Shuqin Cao, Maria Jose Lagartos-Donate, Cui-Zan Cai, Li-Ming Xie, Domenica Caponio, Wen-Wen Wang, Tomas Schmauck-Medina, Jianying Zhang, He-ling Wang, Guofeng Lou, Xianglu Xiao, Wenhua Zheng, Konstantinos Palikaras, Guang Yang, Kim A. Caldwell, Guy A. Caldwell, Han-Ming Shen, Hilde Nilsen, Jia-Hong Lu, Evandro F. Fang
Summary: This study utilized machine learning and a cross-species approach to identify and validate two potent mitophagy inducers. These compounds improved neuronal survival and functionality, abrogated pathology in AD models, and enhanced memory.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Neurosciences
Saranna Fanning, Haley Cirka, Jennifer L. Thies, Jooyoung Jeong, Sarah M. Niemi, Joon Yoon, Gary P. H. Ho, Julian A. Pacheco, Ulf Dettmer, Lei Liu, Clary B. Clish, Kevin J. Hodgetts, John N. Hutchinson, Christina R. Muratore, Guy A. Caldwell, Kim A. Caldwell, Dennis Selkoe
Summary: Study finds targeting lipid metabolism can reverse pathological phenotypes of synucleinopathy and identifies lipase enzyme LIPE as a potential therapeutic target.
NPJ PARKINSONS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Melanie Mew, Kim A. Caldwell, Guy A. Caldwell
Summary: The exponential growth of DNA sequencing data has provided new opportunities for discovering the role of SNPs in neurological diseases. Invertebrate models, such as flies and worms, have proven to be valuable tools for classifying genetic variants and accelerating drug development for these diseases.
HUMAN MOLECULAR GENETICS
(2022)
Article
Genetics & Heredity
Anthony L. Gaeta, J. Brucker Nourse, Karolina Willicott, Luke E. Mckay, Candice M. Keogh, Kylie Peter, Shannon N. Russell, Shusei Hamamichi, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell
Summary: The fine-tuning of gene expression is crucial for cellular processes, and dysregulation can lead to disease. This study examines the effects of gene silencing defects on Parkinson's disease in Caenorhabditis elegans, and identifies specific microRNAs and their targets that modulate neurodegeneration. The findings suggest potential therapeutic targets for PD intervention.
Article
Multidisciplinary Sciences
J. Brucker Nourse, Shannon N. Russell, Nathan A. Moniz, Kylie Peter, Lena M. Seyfarth, Madison Scott, Han-A Park, Kim A. Caldwell, Guy A. Caldwell
Summary: This study investigates the TNK2 gene variants in Parkinson's disease (PD) patients and their potential impact on dopaminergic neurodegeneration. The findings suggest that TNK2 dysfunction may contribute to PD, possibly through sustained or aberrant activity. The study also highlights the importance of TNK2 and its ortholog SID-3 in coordinating dopaminergic and epigenetic signaling. Experimental results using Caenorhabditis elegans and rat primary neurons demonstrate the neuroprotective effects of TNK2 inhibition and NEDD4 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Endocrinology & Metabolism
Linda G. Yang, Zachary M. March, Roxan A. Stephenson, Priyanka S. Narayan
Summary: Dysregulation of lipid metabolism plays a crucial role in neurodegenerative diseases, including late-onset Alzheimer's disease. Variants of the APOE gene affect lipid metabolism and are associated with cellular and systemic phenotypes. Targeting APOE-associated metabolic pathways could potentially alter disease-related phenotypes and reduce the risk of neurodegenerative diseases.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Cell Biology
Jennifer L. Thies, Karolina Willicott, Maici L. Craig, Madeline R. Greene, Cassandra N. DuGay, Guy A. Caldwell, Kim A. Caldwell
Summary: Exposure to S. ven metabolites enhances oxidative stress and mitochondrial dysfunction in C. elegans, leading to dopaminergic neurodegeneration. Gene analysis reveals that a majority of the differentially expressed genes are associated with the transcription factor DAF-16 (FOXO). Exposure to S. ven metabolites also increases XO activity in C. elegans.
Article
Multidisciplinary Sciences
Anthony L. Gaeta, Karolina Willicott, Corey W. Willicott, Luke E. Mckay, Candice M. Keogh, Tyler J. Altman, Logan C. Kimble, Abigail L. Yarbrough, Kim A. Caldwell, Guy A. Caldwell
Summary: Failure of protective cellular processes and misfolded protein-associated stress contribute to the loss of dopamine neurons in Parkinson's disease. The microbiome has been found to play a role in PD, and C. elegans is used as a model to study gene expression and neurodegeneration in transgenic animals. Different gene expression and neuroprotective responses were observed in C. elegans strains overexpressing alpha-synuclein when fed different bacterial food sources. Genetic analysis revealed the involvement of the dsRNA-mediated gene silencing machinery and endopeptidase activity in neuroprotection.
Article
Developmental Biology
Lindsey A. Starr, Luke E. McKay, Kylie N. Peter, Lena M. Seyfarth, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell
Summary: Reduced expression of xdh-1, the ortholog of human xanthine dehydrogenase (XDH), is protective against alpha-synuclein-induced dopaminergic neurodegeneration. The worm ortholog of the human ABCG2 transporter, WHT-2, is the rate-limiting factor in this system. Modifying specific targets of RNA editing may represent a promising therapeutic strategy for Parkinson's disease.
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2023)