TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

(2018) Guoliang Lyu et al.   Nature Communications

Haplodeficiency of activin receptor-like kinase 4 alleviates myocardial infarction-induced cardiac fibrosis and preserves cardiac function

(2017) Yi-He Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Brain trauma and autophagy: What flies and mice can teach us about conserved responses

(2016) Eric P. Ratliff et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells

(2016) Long-Xing Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways

(2016) Juan Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Partial inhibition of activin receptor-like kinase 4 attenuates pressure overload-induced cardiac fibrosis and improves cardiac function

(2016) Chang-Yi Li et al.   JOURNAL OF HYPERTENSION

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury

(2016) Ayeh Barekat et al.   Scientific Reports

Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles

(2016) Eric P. Ratliff et al.   PLoS One

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

(2015) Emma L. Baar et al.   AGING CELL

DrosophilaGyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis

(2015) Myungjin Kim et al.   Autophagy

Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy

(2015) Pankaj Shende et al.   CARDIOVASCULAR RESEARCH

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

(2015) Marcel Tiebe et al.   DEVELOPMENTAL CELL

TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules

(2015) Irena Jevtov et al.   JOURNAL OF CELL SCIENCE

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1

(2015) Sebastiano Sciarretta et al.   Cell Reports

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

(2014) Dudley W. Lamming et al.   AGING CELL

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis

(2014) Yuyan Xiong et al.   Autophagy

Regulation and actions of activin A and follistatin in myocardial ischaemia–reperfusion injury

(2014) Yi Chen et al.   CYTOKINE

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

(2014) Jianzhong Li et al.   KIDNEY INTERNATIONAL

Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster

(2014) A. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor β/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

(2014) Wen-bin Alfred Chng et al.   Cell Reports

Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway

(2014) Fabio Demontis et al.   Cell Reports

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity

(2013) Debapriya Dutta et al.   Autophagy

A current perspective of autophagosome biogenesis

(2013) Shusaku T Shibutani et al.   CELL RESEARCH

Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance

(2013) Z. Wu et al.   GENES & DEVELOPMENT

The expression and role of activin A and follistatin in heart failure rats after myocardial infarction

(2013) Qun Wei et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Evolutionarily conserved regulation of TOR signalling

(2013) T. Takahara et al.   JOURNAL OF BIOCHEMISTRY

An In Vivo Functional Analysis System for Renal Gene Discovery in Drosophila Pericardial Nephrocytes

(2013) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

(2012) Dao-Fu Dai et al.   ANTIOXIDANTS & REDOX SIGNALING

Activin signaling as an emerging target for therapeutic interventions

(2012) Kunihiro Tsuchida et al.   Cell Communication and Signaling

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila

(2012) Karolina Pircs et al.   PLoS One

dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila

(2012) Véronique Monnier et al.   PLoS Genetics

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish

(2011) Yonghe Ding et al.   CIRCULATION RESEARCH

mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy

(2010) Xiaoxiao Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction

(2010) Sih Min Tan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila

(2010) Ryan T. Birse et al.   Cell Metabolism

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

(2010) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

d4eBPacts downstream of both dTOR and dFoxo to modulate cardiac functional aging inDrosophila

(2009) Robert Wessells et al.   AGING CELL

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(2009) Maria L. Florez-McClure et al.   Autophagy

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts

(2009) Martin Fink et al.   BIOTECHNIQUES

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

(2009) Narasimman Gurusamy et al.   CARDIOVASCULAR RESEARCH

Activin A and Follistatin-Like 3 Determine the Susceptibility of Heart to Ischemic Injury

(2009) Yuichi Oshima et al.   CIRCULATION

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner

(2009) Hervé Tricoire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY