标题
Targeting the TGFβ signalling pathway in disease
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 11, Issue 10, Pages 790-811
出版商
Springer Nature
发表日期
2012-09-24
DOI
10.1038/nrd3810
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- First human dose (FHD) study of the oral transforming growth factor-beta receptor I kinase inhibitor LY2157299 in patients with treatment-refractory malignant glioma.
- (2017) J. Rodon Ahnert et al. JOURNAL OF CLINICAL ONCOLOGY
- Effects of Avotermin (Transforming Growth Factor β3) in a Clinically Relevant Pig Model of Long, Full-Thickness Incisional Wounds
- (2015) Hugh G. Laverty et al. JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
- Abstract 1: Mcl-1 downregulation plays a crucial role in the synergistic anticancer activities between PI-3 kinase inhibitors and histone deacetylase inhibitors in primary NSCLC tumorsin vitroandin vivo
- (2012) Hao Zhang et al. CANCER RESEARCH
- Abstract 1366: Development of murine models of breast cancer metastasis for the evaluation of the efficacy of TGF-β inhibitors as therapeutic agents
- (2012) Tanuka Biswas et al. CANCER RESEARCH
- Abstract 5234: Microenvironmental signals dictate disseminated tumor cells (DTCs) fate through regulation of TGFβII and p38α
- (2012) Paloma Bragado et al. CANCER RESEARCH
- Abstract 5367: Long-term survival in a phase II atudy of belagenpumatucel-L (TGF-β antisense modified tumor cell vaccine) in non-small cell lung cancer (NSCLC).
- (2012) Lyudmila Bazhenova et al. CANCER RESEARCH
- Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
- (2012) Hui Yao Lan International Journal of Biological Sciences
- TGFβ Signaling and Cardiovascular Diseases
- (2012) Evangelia Pardali International Journal of Biological Sciences
- Cancer and Innate Immune System Interactions
- (2012) Yanan Liu et al. JOURNAL OF IMMUNOTHERAPY
- Extended adjuvant temozolomide for treatment of newly diagnosed glioblastoma multiforme
- (2012) Gloria B. Roldán Urgoiti et al. JOURNAL OF NEURO-ONCOLOGY
- Stromedix acquisition signals growing interest in fibrosis
- (2012) Malorye Allison NATURE BIOTECHNOLOGY
- The paradoxical TGF-β vasculopathies
- (2012) Rosemary J. Akhurst NATURE GENETICS
- Biogen acquires Stromedix to pursue novel fibrosis therapy
- (2012) Sarah Crunkhorn NATURE REVIEWS DRUG DISCOVERY
- RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
- (2012) Fei Su et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia
- (2012) Michael Benzinou et al. Nature Communications
- Pirfenidone treatment of idiopathic pulmonary fibrosis
- (2012) Arata Azuma Therapeutic Advances in Respiratory Disease
- Blockade of TSP1-Dependent TGF-β Activity Reduces Renal Injury and Proteinuria in a Murine Model of Diabetic Nephropathy
- (2011) Ailing Lu et al. AMERICAN JOURNAL OF PATHOLOGY
- Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis
- (2011) Harold A. Chapman Annual Review of Physiology
- Protective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney
- (2011) Cabir Alan et al. Archives of Medical Science
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
- (2011) Michael Quante et al. CANCER CELL
- Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma
- (2011) N Rainusso et al. CANCER GENE THERAPY
- Blockade of TGF- Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma
- (2011) M. Zhang et al. CANCER RESEARCH
- Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer
- (2011) Karl-Hermann Schlingensiepen et al. CANCER SCIENCE
- TGF-β in progression of liver disease
- (2011) Steven Dooley et al. CELL AND TISSUE RESEARCH
- Transforming growth factor β (TGFβ)-induced apoptosis: The rise and fall of Bim
- (2011) Sneha Ramesh et al. CELL CYCLE
- Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling
- (2011) Hariom Yadav et al. Cell Metabolism
- Skin Tumors Induced by Sorafenib; Paradoxic RAS-RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1
- (2011) J. P. Arnault et al. CLINICAL CANCER RESEARCH
- TGF 1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo
- (2011) F. Bouquet et al. CLINICAL CANCER RESEARCH
- Management of Idiopathic Pulmonary Fibrosis
- (2011) Stefania Cerri et al. CLINICS IN CHEST MEDICINE
- Long-term Follow-up After Lamellar Keratoplasty in a Patient With Bilateral Idiopathic Corneal Keloid
- (2011) Ken Fukuda et al. CORNEA
- Antibody Targeting of TGF-β in Cancer Patients
- (2011) Scott Lonning et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Mouse T helper 17 phenotype: Not so different than in man after all
- (2011) Francesco Annunziato et al. CYTOKINE
- Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo
- (2011) Andrea Conidi et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Exploring anti-TGF-β therapies in cancer and fibrosis
- (2011) Lukas J. A. C. Hawinkels et al. GROWTH FACTORS
- Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation
- (2011) Ilona Gutcher et al. IMMUNITY
- Epithelial-mesenchymal transition in renal fibrosis - evidence for and against
- (2011) Maria Fragiadaki et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Angiotensin receptor blockade attenuates cigarette smoke–induced lung injury and rescues lung architecture in mice
- (2011) Megan Podowski et al. JOURNAL OF CLINICAL INVESTIGATION
- Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
- (2011) Stephanie A. McClymont et al. JOURNAL OF IMMUNOLOGY
- Transcriptional Inhibition of Hypertrophic Scars by a Gene Silencer, Pyrrole–Imidazole Polyamide, Targeting the TGF-β1 Promoter
- (2011) Hisayo Washio et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Inhibition of transforming growth factor-β restores endothelial thromboresistance in vein grafts
- (2011) Navin K. Kapur et al. JOURNAL OF VASCULAR SURGERY
- A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
- (2011) Howard Trachtman et al. KIDNEY INTERNATIONAL
- Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials
- (2011) Paul W Noble et al. LANCET
- PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor
- (2011) Yozo Nakazawa et al. MOLECULAR THERAPY
- Latent TGF-β structure and activation
- (2011) Minlong Shi et al. NATURE
- Gene therapy finds its niche
- (2011) Cormac Sheridan NATURE BIOTECHNOLOGY
- Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1
- (2011) David R Goudie et al. NATURE GENETICS
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interaction of TGFβ and BMP Signaling Pathways during Chondrogenesis
- (2011) Bettina Keller et al. PLoS One
- Smad-mediated miRNA processing
- (2011) Brandi N. Davis-Dusenbery et al. RNA Biology
- Noncanonical TGF Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice
- (2011) T. M. Holm et al. SCIENCE
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring
- (2011) Nick L. Occleston et al. WOUND REPAIR AND REGENERATION
- Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction
- (2010) Sih Min Tan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
- (2010) Judit Anido et al. CANCER CELL
- Reduced SMAD7 Leads to Overactivation of TGF- Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF- Receptor I Kinase
- (2010) L. Zhou et al. CANCER RESEARCH
- Combination effect of a TGF-β receptor kinase inhibitor with 5-FU analog S1 on lymph node metastasis of scirrhous gastric cancer in mice
- (2010) Osamu Shinto et al. CANCER SCIENCE
- Gain or loss of TGF-β signaling in mammary carcinoma cells can promote metastasis
- (2010) Brian Bierie et al. CELL CYCLE
- Anti-Transforming Growth Factor Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells
- (2010) Z. Zhong et al. CLINICAL CANCER RESEARCH
- HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors
- (2010) N. Ahmed et al. CLINICAL CANCER RESEARCH
- Therapeutic effect of a peptide inhibitor of TGF-β on pulmonary fibrosis
- (2010) Laura Arribillaga et al. CYTOKINE
- The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential
- (2010) H. Y. Chen et al. DIABETES
- Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice
- (2010) Andrew C. Melton et al. JOURNAL OF CLINICAL INVESTIGATION
- αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice
- (2010) Mridu Acharya et al. JOURNAL OF CLINICAL INVESTIGATION
- Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter
- (2010) Adèle Hannigan et al. JOURNAL OF CLINICAL INVESTIGATION
- Angiotensin II sustains brain inflammation in mice via TGF-β
- (2010) Tobias V. Lanz et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis
- (2010) Vidya Ganapathy et al. Molecular Cancer
- TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
- (2010) Kazuhito Naka et al. NATURE
- Generation of pathogenic TH17 cells in the absence of TGF-β signalling
- (2010) Kamran Ghoreschi et al. NATURE
- Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3
- (2010) Takashi Maruyama et al. NATURE IMMUNOLOGY
- Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study
- (2010) U. Bogdahn et al. NEURO-ONCOLOGY
- Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells
- (2010) S Ehata et al. ONCOGENE
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- TGF-β Inhibition Restores Terminal Osteoblast Differentiation to Suppress Myeloma Growth
- (2010) Kyoko Takeuchi et al. PLoS One
- Doxorubicin in Combination with a Small TGFβ Inhibitor: A Potential Novel Therapy for Metastatic Breast Cancer in Mouse Models
- (2010) Abhik Bandyopadhyay et al. PLoS One
- BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation
- (2010) R. B. Corcoran et al. Science Signaling
- TGF-β through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation
- (2009) Shirling Tsai et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma
- (2009) Silvia Peñuelas et al. CANCER CELL
- Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
- (2009) Zvi G. Fridlender et al. CANCER CELL
- Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients
- (2009) J Nemunaitis et al. CANCER GENE THERAPY
- Targeting transforming growth factor-β signaling in liver metastasis of colon cancer
- (2009) Bixiang Zhang et al. CANCER LETTERS
- Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors
- (2009) Hiroaki Ikushima et al. Cell Stem Cell
- Searching for MiR-acles in Cardiac Fibrosis
- (2009) Eva van Rooij et al. CIRCULATION RESEARCH
- Immunotherapy for Human Renal Cell Carcinoma by Adoptive Transfer of Autologous Transforming Growth Factor -Insensitive CD8+ T Cells
- (2009) L. Wang et al. CLINICAL CANCER RESEARCH
- Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition
- (2009) Carl-Henrik Heldin et al. CURRENT OPINION IN CELL BIOLOGY
- Strategies for TGF-β modulation: a review of recent patents
- (2009) Dominique Bonafoux et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease
- (2009) P Ranjzad et al. GENE THERAPY
- Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation
- (2009) Antonio Mazzocca et al. HEPATOLOGY
- Peptide inhibitors of transforming growth factor-β enhance the efficacy of antitumor immunotherapy
- (2009) Diana Llopiz et al. INTERNATIONAL JOURNAL OF CANCER
- Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer
- (2009) Brian Bierie et al. JOURNAL OF CLINICAL INVESTIGATION
- The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling
- (2009) Douglas S. Micalizzi et al. JOURNAL OF CLINICAL INVESTIGATION
- Keratoacanthomas and Squamous Cell Carcinomas in Patients Receiving Sorafenib
- (2009) Jean Philippe Arnault et al. JOURNAL OF CLINICAL ONCOLOGY
- Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
- (2009) Jyoti Das et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pretranscriptional Regulation of Tgf-β1 by PI Polyamide Prevents Scarring and Accelerates Wound Healing of the Cornea After Exposure to Alkali
- (2009) Min Chen et al. MOLECULAR THERAPY
- Transforming Growth Factor β–Induced Endothelial-to-Mesenchymal Transition: A Switch to Cardiac Fibrosis?
- (2009) Marie-José Goumans et al. TRENDS IN CARDIOVASCULAR MEDICINE
- SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model
- (2008) Kai Fu et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Validity, reliability, and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial
- (2008) Peter A. Merkel et al. ARTHRITIS AND RHEUMATISM
- TGF-β signalling-related markers in cancer patients with bone metastasis
- (2008) Jose Baselga et al. BIOMARKERS
- Antibody-Mediated Blockade of Integrin v 6 Inhibits Tumor Progression In vivo by a Transforming Growth Factor- Regulated Mechanism
- (2008) L. A. Koopman Van Aarsen et al. CANCER RESEARCH
- Systemic Blockade of Transforming Growth Factor- Signaling Augments the Efficacy of Immunogene Therapy
- (2008) S. Kim et al. CANCER RESEARCH
- An Anti-Transforming Growth Factor Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments
- (2008) J.-S. Nam et al. CANCER RESEARCH
- A pyrrole–imidazole polyamide targeting transforming growth factor-β1 inhibits restenosis and preserves endothelialization in the injured artery
- (2008) En-Hui Yao et al. CARDIOVASCULAR RESEARCH
- A synthetic peptide from transforming growth factor- 1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats
- (2008) N. Hermida et al. CARDIOVASCULAR RESEARCH
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- TGFβ in Cancer
- (2008) Joan Massagué CELL
- Roles of TGFβ in metastasis
- (2008) David Padua et al. CELL RESEARCH
- Signaling cross-talk between TGF-β/BMP and other pathways
- (2008) Xing Guo et al. CELL RESEARCH
- Transforming Growth Factor- Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers
- (2008) A. Wallace et al. CLINICAL CANCER RESEARCH
- Acquired resistance to tyrosine kinase inhibitors during cancer therapy
- (2008) Jeffrey A Engelman et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Activin/TGFβ and BMP crosstalk determines digit chondrogenesis
- (2008) Juan A. Montero et al. DEVELOPMENTAL BIOLOGY
- Smad7 gene transfer therapy: therapeutic applications beyond colonic fibrosis
- (2008) Shailendra Kapoor EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
- (2008) Emilia Fransvea et al. HEPATOLOGY
- Small Molecular Inhibitor of Transforming Growth Factor-β Protects Against Development of Radiation-Induced Lung Injury
- (2008) Mitchell S. Anscher et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Autoimmune Hemolytic Anemia Associated With Ovarian Cancer
- (2008) Patrick G. Morris et al. JOURNAL OF CLINICAL ONCOLOGY
- Antitumor Activity of EBV-specific T Lymphocytes Transduced With a Dominant Negative TGF-?? Receptor
- (2008) Aaron E. Foster et al. JOURNAL OF IMMUNOTHERAPY
- LY2109761, a novel transforming growth factor receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
- (2008) D. Melisi et al. MOLECULAR CANCER THERAPEUTICS
- Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis
- (2007) M. Petersen et al. KIDNEY INTERNATIONAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started