Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

(2012) Subhash D. Katewa et al.   Cell Metabolism

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan

(2011) Rochele Yamamoto et al.   AGING CELL

dFOXO-independent effects of reduced insulin-like signaling inDrosophila

(2011) Cathy Slack et al.   AGING CELL

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

(2011) N. Alic et al.   Molecular Systems Biology

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

(2011) Sri Devi Narasimhan et al.   PLoS Genetics

TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance

(2010) Shijing Luo et al.   CELL

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Partial ablation of adult Drosophilainsulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance

(2010) Aaron Haselton et al.   CELL CYCLE

Autophagy takes flight in Drosophila

(2010) Yu-Yun Chang et al.   FEBS LETTERS

TGF-β1 Protects against Mesangial Cell Apoptosis via Induction of Autophagy

(2010) Yan Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO

(2010) Eugene Schuster et al.   Molecular Systems Biology

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Cell death duringDrosophila melanogasterearly oogenesis is mediated through autophagy

(2009) Ioannis P. Nezis et al.   Autophagy

Informatics approaches to understanding TGF  pathway regulation

(2009) P. Kahlem et al.   DEVELOPMENT

A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States

(2009) Maija Slaidina et al.   DEVELOPMENTAL CELL

The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner

(2009) Hervé Tricoire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon

(2009) Philip A. Jensen et al.   MECHANISMS OF DEVELOPMENT

PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls

(2009) Joel Rozowsky et al.   NATURE BIOTECHNOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-ß Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging

(2009) Shijing Luo et al.   PLoS Genetics

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Nutritional Control of Protein Biosynthetic Capacity by Insulin via Myc in Drosophila

(2008) Aurelio A. Teleman et al.   Cell Metabolism

Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain

(2008) C. C. Zhu et al.   DEVELOPMENT

The BMP-Binding Protein Crossveinless 2 Is a Short-Range, Concentration-Dependent, Biphasic Modulator of BMP Signaling in Drosophila

(2008) Mihaela Serpe et al.   DEVELOPMENTAL CELL

Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

(2008) Kyu-Sun Lee et al.   NATURE CELL BIOLOGY

A large genome center's improvements to the Illumina sequencing system

(2008) Michael A Quail et al.   NATURE METHODS

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA