标题
mTOR complex 2 signaling and functions
作者
关键词
-
出版物
CELL CYCLE
Volume 10, Issue 14, Pages 2305-2316
出版商
Informa UK Limited
发表日期
2011-08-02
DOI
10.4161/cc.10.14.16586
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1
- (2016) Gino Heeren et al. Aging-US
- Growth and aging: a common molecular mechanism
- (2016) Mikhail V. Blagosklonny et al. Aging-US
- The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
- (2016) Lioubov G. Korotchkina et al. Aging-US
- Regulation of plant growth and metabolism by the TOR kinase
- (2011) Thomas Dobrenel et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- Targeting mTOR globally in cancer: Thinking beyond rapamycin
- (2011) Boris Shor et al. CELL CYCLE
- Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
- (2011) Hilary P. Glazer et al. CELL CYCLE
- Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
- (2011) Yanyun Gu et al. DIABETES
- Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
- (2011) Xiaoqing Gan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
- (2011) Abdelhafid Saci et al. MOLECULAR CELL
- TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation
- (2011) Yi-Hung Ou et al. MOLECULAR CELL
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
- (2011) Greg M Delgoffe et al. NATURE IMMUNOLOGY
- I B kinase and TANK-binding kinase 1 activate AKT by direct phosphorylation
- (2011) X. Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
- (2011) Michelle C. Mendoza et al. TRENDS IN BIOCHEMICAL SCIENCES
- Steady-State Kinetic and Inhibition Studies of the Mammalian Target of Rapamycin (mTOR) Kinase Domain and mTOR Complexes
- (2010) Zhihua Tao et al. BIOCHEMISTRY
- Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
- (2010) P. S. Bachmann et al. BLOOD
- mTOR Complex Component Rictor Interacts with PKC and Regulates Cancer Cell Metastasis
- (2010) F. Zhang et al. CANCER RESEARCH
- mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion
- (2010) Lunhua Liu et al. DEVELOPMENTAL CELL
- Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
- (2010) A. Kumar et al. DIABETES
- Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
- (2010) V. P. Houde et al. DIABETES
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
- (2010) Won Jun Oh et al. EMBO JOURNAL
- Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
- (2010) H. Takai et al. GENES & DEVELOPMENT
- Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways
- (2010) Keunwook Lee et al. IMMUNITY
- Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling
- (2010) Irantzu Tato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prostaglandin E2Activates and Utilizes mTORC2 as a Central Signaling Locus for the Regulation of Mast Cell Chemotaxis and Mediator Release
- (2010) Hye Sun Kuehn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
- (2010) Takeshi Kaizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR Complex-2 Activates ENaC by Phosphorylating SGK1
- (2010) M. Lu et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
- (2010) D. Boulbes et al. MOLECULAR CANCER RESEARCH
- CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability
- (2010) Zuzana Hořejší et al. MOLECULAR CELL
- Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells
- (2010) Adam S. Lazorchak et al. MOLECULAR CELL
- Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction
- (2010) Daming Gao et al. MOLECULAR CELL
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
- (2010) Calvin K. Yip et al. MOLECULAR CELL
- Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
- (2010) Shomit Sengupta et al. MOLECULAR CELL
- Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
- (2010) Matthew R Janes et al. NATURE MEDICINE
- PKC and the control of localized signal dynamics
- (2010) Carine Rosse et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction
- (2010) M Colombi et al. ONCOGENE
- Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
- (2010) C A Sparks et al. ONCOGENE
- Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
- (2010) Nathalie Carayol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma
- (2010) Q.-W. Fan et al. Science Signaling
- Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice
- (2010) Michael A. Siuta et al. PLOS BIOLOGY
- Protein kinase C: poised to signal
- (2009) Alexandra C. Newton AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
- (2009) David A. Guertin et al. CANCER CELL
- TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
- (2009) J. Copp et al. CANCER RESEARCH
- Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors
- (2009) J. Huang et al. CANCER RESEARCH
- AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
- (2009) C. M. Chresta et al. CANCER RESEARCH
- Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
- (2009) K. Yu et al. CANCER RESEARCH
- Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
- (2009) Narasimman Gurusamy et al. CARDIOVASCULAR RESEARCH
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
- (2009) E.A. Dunlop et al. CELLULAR SIGNALLING
- mTOR and the control of whole body metabolism
- (2009) Pazit Polak et al. CURRENT OPINION IN CELL BIOLOGY
- Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
- (2009) A. A. Soukas et al. GENES & DEVELOPMENT
- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
- (2009) Greg M. Delgoffe et al. IMMUNITY
- mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
- (2009) Ghada A. Soliman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
- (2009) Valérie Risson et al. JOURNAL OF CELL BIOLOGY
- Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
- (2009) C. C. Dibble et al. MOLECULAR AND CELLULAR BIOLOGY
- Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth
- (2009) H. A. Acosta-Jaquez et al. MOLECULAR AND CELLULAR BIOLOGY
- mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
- (2009) L.-A. Julien et al. MOLECULAR AND CELLULAR BIOLOGY
- The mTORC2 Complex Regulates Terminal Differentiation of C2C12 Myoblasts
- (2009) L. Shu et al. MOLECULAR AND CELLULAR BIOLOGY
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTOR complex 2 in adipose tissue negatively controls whole-body growth
- (2009) N. Cybulski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Akt/GSK3 Signaling in the Action of Psychotropic Drugs
- (2008) Jean-Martin Beaulieu et al. Annual Review of Pharmacology and Toxicology
- Hsp70 associates with Rictor and is required for mTORC2 formation and activity
- (2008) Jheralyn Martin et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival
- (2008) P. C. McDonald et al. CANCER RESEARCH
- p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
- (2008) Andrei V. Budanov et al. CELL
- Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
- (2008) C. Florian Bentzinger et al. Cell Metabolism
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
- (2008) Tsuneo Ikenoue et al. EMBO JOURNAL
- The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
- (2008) Valeria Facchinetti et al. EMBO JOURNAL
- Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1
- (2008) M. Rosner et al. HUMAN MOLECULAR GENETICS
- Regulation of a Third Conserved Phosphorylation Site in SGK1
- (2008) Wei Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In VivoAnalysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis
- (2008) Banu Surucu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Chaperones Hsp90 and Cdc37 Mediate the Maturation and Stabilization of Protein Kinase C through a Conserved PXXP Motif in the C-terminal Tail
- (2008) Christine M. Gould et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner
- (2008) I. Patursky-Polischuk et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin
- (2008) A. Toschi et al. MOLECULAR AND CELLULAR BIOLOGY
- A Rictor-Myo1c Complex Participates in Dynamic Cortical Actin Events in 3T3-L1 Adipocytes
- (2008) G. N. Hagan et al. MOLECULAR AND CELLULAR BIOLOGY
- The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2
- (2008) J. Huang et al. MOLECULAR AND CELLULAR BIOLOGY
- Syndecan-4 Regulates Subcellular Localization of mTOR Complex2 and Akt Activation in a PKCα-Dependent Manner in Endothelial Cells
- (2008) Chohreh Partovian et al. MOLECULAR CELL
- A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress
- (2008) D. Ghosh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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