Article
Plant Sciences
Maria Juliana Calderan-Rodrigues, Marcin Luzarowski, Carolina Cassano Monte-Bello, Romina I. Minen, Boris M. Zuehlke, Zoran Nikoloski, Aleksandra Skirycz, Camila Caldana
Summary: Plants as autotrophic organisms capture light energy to convert carbon dioxide into ATP, NADPH, and sugars for biosynthesis. During night, metabolism and growth can be sustained by mobilizing carbon reserves. Proteogenic dipeptides act as metabolic switches in plants, regulating enzymatic activities and contributing to metabolic rewiring during day-night cycles.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tingting Zhu, Linxuan Li, Huimin Chang, Jiasui Zhan, Maozhi Ren
Summary: The microalga Auxenochlorella pyrenoidosa is an efficient photosynthetic organism with rich nutrition and high protein content. This study identified a conserved ApTOR protein in Auxenochlorella pyrenoidosa and found that its growth can be effectively inhibited by AZD8055. Transcriptome data revealed the important roles of ApTOR in photosynthesis, intracellular metabolism, and cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
Maria Jose Garcia, Macarena Angulo, Carlos Lucena, Rafael Perez-Vicente, Francisco Javier Romera
Summary: To cope with nutrient scarcity, plants employ two main strategies - stopping growing to reduce nutrient demand, and searching for nutrients through physiological and morphological responses in roots. The interconnection between these strategies is not well understood, but recent research suggests that the plant hormone ethylene may play a crucial role in connecting them. The TOR system is known to be a central regulator of growth in response to nutrients, and ethylene activation is involved in many nutrient deficiency responses.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Limei Song, Guoyun Xu, Tingting Li, Huina Zhou, Qinlu Lin, Jia Chen, Long Wang, Dousheng Wu, Xiaoxu Li, Lifeng Wang, Sirui Zhu, Feng Yu
Summary: The TOR kinase is activated in plants by interacting with the receptor kinase FERONIA (FER), which helps regulate nitrogen and amino acid signaling under low-nutrient conditions and promotes leaf growth.
Article
Microbiology
Ziyu Liu, Junjie Tian, Zhengang Miao, Wenxing Liang, Guangyuan Wang
Summary: In this study, metabolomics and transcriptomics analysis revealed that rapamycin treatment altered multiple metabolic processes of Yarrowia lipolytica in nitrogen-rich medium, especially the metabolisms of amino acids and lipids.
Article
Biochemistry & Molecular Biology
Seishu Gen, Yu Matsumoto, Tsukasa Suzuki, Jun Inoue, Yuji Yamamoto
Summary: The tumor-suppressor protein TSC2 is regulated by insulin, energy, oxygen, and growth factors, and its dysfunction can lead to cell growth through activation of mTORC1. Methionine affects TSC2 stability and localization, and interacts with insulin signaling through TSC2 to modulate cell growth pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Foltman, Alberto Sanchez-Diaz
Summary: This article focuses on the significance of the highly conserved TOR signaling pathway, particularly the connection between TORC1 complex in budding yeast and the cell cycle, and the importance of this connection for cell size and chromosome stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohee, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor Korolchuk, Ineke van't Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michele Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloe Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck
Summary: The study found that Ras GTPase-activating protein-binding proteins 1 and 2 are core components of stress granules and play a key role at the cytoplasmic surface of lysosomes. They anchor the tuberous sclerosis complex protein complex to lysosomes in a non-redundant manner, suppressing the activation of mTORC1. Deficiency in G3BP1 can lead to phenotypes related to mTORC1 hyperactivity, and low G3BP1 levels in tumors enhance mTORC1-driven cell motility and correlate with poor outcomes in patients. Additionally, inhibition of G3bp1 in zebrafish affects neuronal development and function.
Article
Plant Sciences
Ahai Chen, Na Liu, Chenghui Xu, Siqi Wu, Chao Liu, Hao Qi, Yiyi Ren, Xingmin Han, Kunlong Yang, Xiao Liu, Zhonghua Ma, Yun Chen
Summary: In this study, the components and function of the STRIPAK complex were investigated in Fusarium graminearum, an important plant-pathogenic fungus. The results revealed that the STRIPAK complex consisted of six proteins and played a crucial role in fungal development and virulence. It was found to interact with the mitogen-activated protein kinase Mgv1 and regulate the fungal stress response and virulence. The study highlighted the importance of the STRIPAK complex in fungal virulence.
MOLECULAR PLANT PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Linxuan Li, Tingting Zhu, Yun Song, Li Feng, Philip James Kear, Rooallah Saberi Riseh, Mahmoud Sitohy, Raju Datla, Maozhi Ren
Summary: This study explored the potential mechanisms of salicylic acid (SA) as a biofungicide by using the highly pathogenic Fusarium oxysporum as a model system. The results showed that SA could inhibit key targets of the pathogen, modify the metabolic activity within pathogen cells, and induce pathogen cell death. This research provides insights into the application of SA in controlling various fungal diseases by targeting the SNF1-TORC1 pathway of pathogens.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Plant Sciences
Qiumin Chen, Mengqi Qu, Qinglei Chen, Xiangnan Meng, Haiyan Fan
Summary: The TOR kinase is a conserved regulator of cell growth in yeasts, plants, and mammals. However, there is a lack of large-scale studies on TOR phosphorylation events under environmental stress. In this study, phosphoproteomics analysis of cucumber under P. xanthii attack with TOR inhibitor pretreatment revealed the unique preferences of TOR in phosphorylation response. These findings provide valuable insights into the molecular mechanism of how TOR kinase controls plant growth and stress adaptation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Jiahui Xu, Gale M. Strasburg, Kent M. Reed, Sandra G. Velleman
Summary: The growth and development of turkey breast muscle are highly sensitive to temperature, which highlights the importance of temperature management immediately after hatch. Excessive enlargement of muscle fibers can lead to muscle damage and fat deposition in the breast meat, impacting meat quality. This study investigates the cellular mechanisms involved in thermal stress-induced fat synthesis in turkey breast muscle satellite cells, providing valuable insights for the development of temperature manipulation strategies to control fat production and improve poultry meat quality.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Plant Sciences
Bjoern Heinemann, Tatjana M. Hildebrandt
Summary: Plants adapt their metabolism to stress-induced energy deficiency by undergoing significant changes in amino acid metabolism. Amino acids can act as alternative substrates for respiratory pathways and also as signaling molecules in response to stress. The regulation of amino acid metabolism during energy deprivation is controlled by the balance between TOR and SnRK signaling, with some amino acids potentially serving as nutrient signals to promote a shift from catabolic to anabolic pathways.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Changli Huang, Lin Li, Lei Wang, Jiandong Bao, Xiaozhi Zhang, Jiongyi Yan, Jiaqi Wu, Na Cao, Jiaoyu Wang, Lili Zhao, Xiaohong Liu, Xiaoping Yu, Xueming Zhu, Fucheng Lin
Summary: A new regulatory factor MoGap1 was identified in M. oryzae, which can affect the level of autophagy by regulating TOR signaling, and plays a role in response to growth-related stress such as cell wall stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Inmaculada Couso, Amanda L. Smythers, Megan M. Ford, James G. Umen, Jose L. Crespo, Leslie M. Hicks
Summary: This study reveals the synergistic role of inositol pyrophosphates and TOR signaling in coordinating cell growth and lipid metabolism in green algae. The inhibitory effect of rapamycin on TOR signaling is more significant in the vip1-1 mutant compared to wild-type, highlighting the independent yet coordinated interaction between InsPs and TOR. Additionally, phosphorylation patterns of photosystem proteins are affected by light stress and other stresses, indicating a novel role for inositol pyrophosphates and TOR signaling in response to environmental cues.
