Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

(2019) Rainer Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

(2018) Emiliano Zamponi et al.   AGING CELL

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer

(2018) Eun Hye Kim et al.   CANCER LETTERS

An Element of Life

(2018) Douglas R. Green   CELL

The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?

(2018) Alexey A. Tinkov et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

(2018) Anja Jelinek et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of lipid peroxidation and ferroptosis in diverse species

(2018) Marcus Conrad et al.   GENES & DEVELOPMENT

MicroRNAs as Potential Regulators of Glutathione Peroxidases Expression and Their Role in Obesity and Related Pathologies

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma

(2018) Yuko Kinowaki et al.   LABORATORY INVESTIGATION

The significance, trafficking and determination of labile iron in cytosol, mitochondria and lysosomes

(2018) Huanhuan Lv et al.   Metallomics

Scavenging of reactive oxygen and nitrogen species with nanomaterials

(2018) Carolina A. Ferreira et al.   Nano Research

Scavenging of superoxide by a membrane-bound superoxide oxidase

(2018) Camilla A. K. Lundgren et al.   Nature Chemical Biology

Biological and Immunological Aspects of Iron Deficiency Anemia in Cancer Development: A Narrative Review

(2018) Fatema Zohora et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D

(2018) Justin B. Belsky et al.   NUTRITION RESEARCH REVIEWS

Trichloroethylene metabolite S-(1,2-dichlorovinyl)- l -cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line

(2018) Elana R. Elkin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Low tumor glutathione level as a sensitivity marker for glutamate‑cysteine ligase inhibitors

(2018) Satoru Nishizawa et al.   Oncology Letters

Selenium and iron, two elemental rivals in the ferroptotic death process

(2018) Irina Ingold et al.   Oncotarget

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Hypoxia enhances H 2 O 2 -mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation

(2018) Inês Silva et al.   Redox Biology

Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using 55Fe and storage phosphorimaging

(2018) M. Krijt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Catalase Enhances Viability of Human Chondrocytes in Culture by Reducing Reactive Oxygen Species and Counteracting Tumor Necrosis Factor-α-Induced Apoptosis

(2018) Siming Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

p53 tumor suppressor and iron homeostasis

(2018) Jin Zhang et al.   FEBS Journal

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

(2018) Xuchu Que et al.   NATURE

Carnosine protects cardiac myocytes against lipid peroxidation products

(2018) Jingjing Zhao et al.   AMINO ACIDS

Inhibition of VDAC1 Protects Against Glutamate-Induced Oxytosis and Mitochondrial Fragmentation in Hippocampal HT22 Cells

(2018) Pandian Nagakannan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

(2018) Kyunghee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

(2018) Yvette Y. Yien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions

(2018) Gong-Jhe Wu et al.   LIFE SCIENCES

The Role of Vitamin E in Immunity

(2018) Ga Lee et al.   Nutrients

Antioxidants and HNE in redox homeostasis

(2017) Wojciech Łuczaj et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

(2017) Huiqin Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases

(2017) Kamelija Zarkovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria

(2017) Mengqing Xiao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Zinc prevents mitochondrial superoxide generation by inducing mitophagy in the setting of hypoxia/reoxygenation in cardiac cells

(2017) Xiyun Bian et al.   FREE RADICAL RESEARCH

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Influence of selenium supplementation on patients with inflammation: A pilot double blind randomized study

(2017) Renata Germano Borges de Oliveira Nascimento Freitas et al.   NUTRITION

Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction

(2017) M. Ito et al.   OSTEOARTHRITIS AND CARTILAGE

Expanding perspectives on the significance of mitophagy in cancer

(2017) Lauren E. Drake et al.   SEMINARS IN CANCER BIOLOGY

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

(2017) Justin R. Prigge et al.   Cell Reports

Therapies targeting lipid peroxidation in traumatic brain injury

(2016) Tamil Selvan Anthonymuthu et al.   BRAIN RESEARCH

Elevated hepatocyte growth factor expression as an autocrine c-Met activation mechanism in acquired resistance to sorafenib in hepatocellular carcinoma cells

(2016) Zeynep Firtina Karagonlar et al.   CANCER SCIENCE

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

C-Jun N-terminal kinase signalling pathway in response to cisplatin

(2016) Dong Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Assessment of Isoprostanes in Human Plasma: Technical Considerations and the Use of Mass Spectrometry

(2016) Yiu Yiu Lee et al.   LIPIDS

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Antioxidant Vitamins and Trace Elements in Critical Illness

(2016) W. A. C. (Kristine) Koekkoek et al.   NUTRITION IN CLINICAL PRACTICE

Parkin and mitophagy in cancer

(2016) J P Bernardini et al.   ONCOGENE

Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration

(2016) Janusz Blasiak et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Autophagy is activated to protect against endotoxic acute kidney injury

(2016) Shuqin Mei et al.   Scientific Reports

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The complexity of apoptotic cell death in mollusks: An update

(2015) A. Romero et al.   FISH & SHELLFISH IMMUNOLOGY

Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women

(2015) Thomas Grenier-Larouche et al.   JOURNAL OF LIPID RESEARCH

Plant glutathione peroxidases: Emerging role of the antioxidant enzymes in plant development and stress responses

(2015) Krisztina Bela et al.   JOURNAL OF PLANT PHYSIOLOGY

C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy

(2015) S R Klein et al.   ONCOGENE

Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement

(2015) Pedro Bullón et al.   PHARMACOLOGICAL RESEARCH

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase

(2015) Gila Idelman et al.   Redox Biology

Demonstration of the Heterolytic OO Bond Cleavage of Putative Nonheme Iron(II)OOH(R) Complexes for Fenton and Enzymatic Reactions

(2014) Suhee Bang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PKCδ regulates hepatic triglyceride accumulation and insulin signaling in Leprdb/db mice

(2014) Jian Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The Action of Peroxyl Radicals, Powerful Deleterious Reagents, Explains Why Neither Cholesterol Nor Saturated Fatty Acids Cause Atherogenesis and Age-Related Diseases

(2014) Gerhard Spiteller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Roles of Reactive Oxygen Species in the Spermatogenesis Regulation

(2014) Giulia Guerriero et al.   Frontiers in Endocrinology

MAPK Cascades in Plant Disease Resistance Signaling

(2013) Xiangzong Meng et al.   Annual Review of Phytopathology

Biomarkers of lipid peroxidation in clinical material

(2013) Etsuo Niki   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism

(2013) Congcong He et al.   CELL

Optimization of the C11-BODIPY581/591dye for the determination of lipid oxidation inChlamydomonas reinhardtiiby flow cytometry

(2013) Giulia Cheloni et al.   CYTOMETRY PART A

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

(2013) Xin Wen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases

(2013) G. K. Sakellariou et al.   FREE RADICAL RESEARCH

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response

(2013) Petra Haberzettl et al.   Redox Biology

Protein Kinase Cδ in Apoptosis: A Brief Overview

(2012) Meng Zhao et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Probing the origins of glutathione biosynthesis through biochemical analysis of glutamate-cysteine ligase and glutathione synthetase from a model photosynthetic prokaryote

(2012) William B. Musgrave et al.   BIOCHEMICAL JOURNAL

Ferroportin-mediated iron transport: Expression and regulation

(2012) Diane M. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE)

(2012) Cagri Bodur et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Free Radical Oxidation of Polyunsaturated Lipids: New Mechanistic Insights and the Development of Peroxyl Radical Clocks

(2011) Derek A. Pratt et al.   ACCOUNTS OF CHEMICAL RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Effect of cooking on total vitamin C contents and antioxidant activity of sweet chestnuts (Castanea sativa Mill.)

(2011) Ana I.R.N.A. Barros et al.   FOOD CHEMISTRY

Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

(2010) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

(2010) Lloyd T. Morgan et al.   BIOCHEMICAL JOURNAL

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

(2010) Pankaj Chaudhary et al.   BIOCHEMISTRY

Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection

(2010) S. R. Clark et al.   BLOOD

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

IL-2-granzyme A chimeric protein overcomes multidrug resistance (MDR) through a caspase 3-independent apoptotic pathway

(2010) Inna Grodzovski et al.   INTERNATIONAL JOURNAL OF CANCER

The paradox of autophagy and its implication in cancer etiology and therapy

(2009) Avital Eisenberg-Lerner et al.   APOPTOSIS

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action

(2009) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Effect of abiotic stresses on glutathione peroxidase and glutathione S-transferase activity in barley root tips

(2009) L’ubica Halušková et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk - A preliminary study

(2008) Marie-Caroline Michalski et al.   MOLECULAR NUTRITION & FOOD RESEARCH