Article
Biochemistry & Molecular Biology
Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang, Li-Yu He
Summary: The study confirmed that IKK inactivates the deubiquitination activity of CYLD by activating the phosphorylation of CYLD, thus promoting the ubiquitination of Nrf2 and further aggravating oxidative stress injury of the kidney in ORN.
MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K. E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quiros, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, Derek P. Narendra
Summary: Mitochondrial stress triggers responses in both cellular mitochondria and nucleus. This study focuses on the impact of a mutation in the mitochondrial protein CHCHD10, which causes myopathy. The study finds that the mutated CHCHD10 aggregates in affected tissues, causing toxic stress on the inner mitochondrial membrane. The research also reveals the crucial role of the mitochondrial metalloendopeptidase OMA1 in coordinating stress responses and reshaping the mitochondrial network and proteome.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Juan Liu, Yuxin Zhuang, Jianlin Wu, Qiang Wu, Meixian Liu, Yue Zhao, Zhongqiu Liu, Caiyan Wang, Linlin Lu, Yingjiao Meng, Kawai Lei, Xiaojuan Li, Qibiao Wu, Elaine Lai-Han Leung, Zhengyang Guo, Liang Liu, Ting Li
Summary: This study found that IKKβ is constitutively activated in healthy individuals and knock-in mice, and its activation may play a role in maintaining homeostasis instead of causing inflammation. Inhibition of IKKβ can disrupt homeostasis, while activation of AMPK can rebuild homeostasis and reduce mortality induced by inflammation.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medicine, General & Internal
Liang-Ti Huang, Hsiu-Chu Chou, Chung-Ming Chen
Summary: The study revealed that exposure to hyperoxia upregulates TRIM72 expression, leading to oxygen-induced lung injury, possibly through TRIM72-dependent alveolar epithelial cell death.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Hematology
Uta Margareta Demel, Raphael Lutz, Stefanie Sujer, Yasmin Demerdash, Shubhankar Sood, Florian Gruenschlaeger, Andrea Kuck, Paula Werner, Sandra Blaszkiewicz, Hannah Julia Uckelmann, Simon Haas, Marieke Alida Gertruda Essers
Summary: This study investigates the response of hematopoietic stem cells (HSCs) to inflammatory stress induced by lipopolysaccharide (LPS) in mice. The researchers find that acute LPS challenge leads to the proliferation of quiescent HSCs, involving a complex cascade of proinflammatory cytokines. These findings provide detailed mechanistic insights into HSC activation during acute infections.
Article
Biochemistry & Molecular Biology
Dongfeng Shi, Yiyi Shan, Xiaoyang Zhu, Haifei Wang, Shenglong Wu, Zhengchang Wu, Wenbin Bao
Summary: This study investigates the role of histone modification in the cytotoxicity induced by mycotoxins using intestinal porcine epithelial cells as a model. The findings suggest that the upregulation of MLL1 and enrichment of H3K4me3 upon DON exposure contribute to increased apoptosis rate, cell cycle arrest, and activation of the MAPK pathway. RNA sequencing analysis reveals that differentially expressed genes are involved in the cell cycle, apoptosis, and TNF signaling pathway. These results provide new insights into the epigenetic mechanism of MLL1 in regulating cytotoxic effects induced by DON.
Article
Biochemistry & Molecular Biology
Orsola di Martino, Haixia Niu, Gayla Hadwiger, Margaret A. Ferris, John S. Welch
Summary: Nur77, an orphan nuclear receptor, is involved in various cellular processes and its transcriptional activity in hematopoietic cells is regulated by intracellular cytokine signaling pathways, with cytokine exposure leading to its activation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Mumtaz Akhtar, Louis D. Trombetta
Summary: Mancozeb is a widely-used fungicide that can mobilize and bio-accumulate essential trace metals in various tissues, as demonstrated in a study on Long-Evans rats. The study found that Mancozeb exposure resulted in increased levels of copper and manganese in the hippocampus and manganese in the liver. Elevated copper levels were also detected in the renal cortex, leading to copper overload and kidney injury.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Ahmet Can Timucin, Huveyda Basaga, Ozgur Kutuk
MEDICINAL RESEARCH REVIEWS
(2019)
Article
Biochemistry & Molecular Biology
Zuhal Kilic-Kurt, Filiz Bakar-Ates, Yeliz Aka, Ozgur Kutuk
BIOORGANIC CHEMISTRY
(2019)
Article
Immunology
Meryem Ozlem Kutuk, Ali Evren Tufan, Fethiye Kilicaslan, Tuba Mutluer, Cem Gokcen, Mehmet Karadag, Cigdem Yektas, Hasan Kandemir, Ahmet Buber, Gulen Guler Aksu, Zehra Topal, Asli Giray, Fatma Celik, Ufuk Acikbas, Ozgur Kutuk
Article
Microbiology
Albert Vallejo-Gracia, Irene P. Chen, Rosalba Perrone, Emilie Besnard, Daniela Boehm, Emilie Battivelli, Tugsan Tezil, Karsten Krey, Kyle A. Raymond, Philip A. Hull, Marius Walter, Ireneusz Habrylo, Andrew Cruz, Steven Deeks, Satish Pillai, Eric Verdin, Melanie Ott
NATURE MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sehime Gulsun Temel, Asli Giray, Bahriye Karakas, Ozgur Gul, Ilknur Kozanoglu, Husnu Celik, Huveyda Basaga, Ufuk Acikbas, Ceren Sucularli, Sidika Oztop, Yeliz Aka, Ozgur Kutuk
Article
Biochemistry & Molecular Biology
Zuhal Kilic-Kurt, Yeliz Aka, Ozgur Kutuk
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Biochemistry & Molecular Biology
Meryem Ozlem Kutuk, Evren Tufan, Cem Gokcen, Fethiye Kilicaslan, Mehmet Karadag, Tuba Mutluer, Cigdem Yektas, Nurdan Coban, Hasan Kandemir, Ahmet Buber, Seyma Coskun, Ufuk Acikbas, Gulen Guler, Zehra Topal, Fatma Celik, Ebru Altintas, Asli Giray, Yeliz Aka, Ozgur Kutuk
Article
Biochemistry & Molecular Biology
Yeliz Aka, Bahriye Karakas, Ufuk Acikbas, Huveyda Basaga, Ozgur Gul, Ozgur Kutuk
Summary: The study revealed that Wee1 is a key target kinase to enhance the sensitivity of breast cancer cells to ABT-199, and its depletion or inhibition can overcome resistance to ABT-199. In addition, suppression of Wee1 leads to increased mitochondrial cell death priming and promotes MCL1 degradation.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Cell Biology
Bahriye Karakas, Yeliz Aka, Asli Giray, Sehime Gulsun Temel, Ufuk Acikbas, Huveyda Basaga, Ozgur Gul, Ozgur Kutuk
Summary: Dynamic BH3 profiling technology can predict the response to endocrine therapy agents and the development of acquired resistance in breast cancer cells independently of estrogen receptor status. Mitochondrial ER-beta plays a crucial role in breast cancer cells, and selective ER-beta agonists may be a novel targeted therapy for breast cancer.
CELL DEATH DISCOVERY
(2021)
Editorial Material
Cell Biology
Tugba Bagci-Onder, Ozgur Kutuk, Triona Ni Chonghaile, Uwe Knippschild
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Ophthalmology
Nedime Sahinoglu Keskek, Imren Akkoyun, Abdulkerim Temiz, Ozgur Kutuk
Summary: This study presents a new disease association involving gastrointestinal tract malformations and familial exudative vitreoretinopathy-like disease. Genetic analysis revealed defects in the Hedgehog signaling pathway in patients with this disease. This is the first study to demonstrate the association between FEVR-like retinal vascular disease and GTMs and highlights the importance of the Hedgehog pathway in retinal vascular and gut development.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Meryem Ozlem Kutuk, Fethiye Kilicaslan, Ali Evren Tufan, Fatma Celik, Cem Gokcen, Harika Gozukara Bag, Gulay Servi, Mehtap Karali, Gamze Bahsi, Ceyhun Servi, Resat Alatli, Betul Kandemir, Neslihan Aytekin, Ozgur Kutuk
Summary: This study evaluates factors related to child marriage compared to unmarried status in female adolescent residents in a refugee camp in Turkey. The rate of child marriage and developmental status of offspring from those marriages are reported. Married females and controls are compared for traumatic experiences and psychopathologies, showing differences in post-traumatic stress disorder (PTSD) diagnosis and developmental delays among offspring of child brides.
CHILDRENS HEALTH CARE
(2022)
Correction
Psychology, Developmental
Meryem Ozlem Kutuk, Ali Evren Tufan, Fethiye Kilicaslan, Gulen Guler, Fatma Celik, Ebru Altintas, Cem Gokcen, Mehmet Karadag, Cigdem Yektas, Tuba Mutluer, Hasan Kandemir, Ahmet Buber, Zehra Topal, Ufuk Acikbas, Asli Giray, Ozgur Kutuk
Summary: The article unfortunately did not include the revised affiliations for the authors.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)
Article
Psychology, Developmental
Meryem Ozlem Kutuk, Ali Evren Tufan, Fethiye Kilicaslan, Gulen Guler, Fatma Celik, Ebru Altintas, Cem Gokcen, Mehmet Karadag, Cigdem Yektas, Tuba Mutluer, Hasan Kandemir, Ahmet Buber, Zehra Topal, Ufuk Acikbas, Asli Giray, Ozgur Kutuk
Summary: The study found significantly elevated levels of depression and burnout among parents of children with ASD compared to controls, with mothers experiencing higher levels of burnout and fathers experiencing higher levels of depression. Parental psychopathology and children's conditions were found to influence the use of complementary and alternative medicine interventions. Providing psychological support and addressing burnout and stress levels in parents of ASD children may benefit the family unit as a whole.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)
Article
Geriatrics & Gerontology
Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P. Simon, Victoria J. Butler, Manfred Jung, Julie Andersen, Aimee W. Kao, Eric Verdin
NPJ AGING AND MECHANISMS OF DISEASE
(2019)