Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

The Conundrum of Hydrogen Peroxide Signaling and the Emerging Role of Peroxiredoxins as Redox Relay Hubs

(2018) Sarah Stöcker et al.   ANTIOXIDANTS & REDOX SIGNALING

Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice

(2017) Jarrod A. Call et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans

(2017) Dylan J. Dues et al.   FREE RADICAL BIOLOGY AND MEDICINE

The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging

(2017) Jiao Meng et al.   Redox Biology

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/ − mice is correlated to increased cellular senescence

(2017) Yiqiang Zhang et al.   Redox Biology

Superoxide dismutase SOD-1 modulates C. elegans pathogen avoidance behavior

(2017) Alexander M. Horspool et al.   Scientific Reports

Superoxide Ion: Generation and Chemical Implications

(2016) Maan Hayyan et al.   CHEMICAL REVIEWS

Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans

(2016) J.Z. Wu et al.   EXPERIMENTAL GERONTOLOGY

The absence of the SOD1 gene causes abnormal monoaminergic neurotransmission and motivational impairment-like behavior in mice

(2016) Daisaku Yoshihara et al.   FREE RADICAL RESEARCH

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans

(2015) Laxmi Rathor et al.   AGE

Lifespan extension and increased resistance to environmental stressors by N-Acetyl-L-Cysteine in Caenorhabditis elegans

(2015) SI Oh et al.   Clinics

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

Reactive nitrogen species in cellular signaling

(2015) Levi Adams et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD

(2015) Kimberly Cramer-Morales et al.   FREE RADICAL BIOLOGY AND MEDICINE

One- and two-electron oxidation of thiols: mechanisms, kinetics and biological fates

(2015) Madia Trujillo et al.   FREE RADICAL RESEARCH

Vascular nitric oxide: Beyond eNOS

(2015) Yingzi Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice

(2015) Naotaka Izuo et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dysfunction and longevity in animals: Untangling the knot

(2015) Y. Wang et al.   SCIENCE

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

(2015) Claire E. Schaar et al.   PLoS Genetics

Mechanisms of Superoxide Signaling in Epigenetic Processes: Relation to Aging and Cancer

(2015) Igor Afanas’ev   Aging and Disease

The physiological role of reversible methionine oxidation

(2014) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cloning and expression analysis ofDrosophilaextracellular Cu Zn superoxide dismutase

(2014) Michael J. Blackney et al.   BIOSCIENCE REPORTS

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Lack of CuZnSOD Leads to Impaired Neurotransmitter Release, Neuromuscular Junction Destabilization and Reduced Muscle Strength in Mice

(2014) Yun Shi et al.   PLoS One

Molecular Basis for Antioxidant Enzymes in Mediating Copper Detoxification in the Nematode Caenorhabditis elegans

(2014) Shaojuan Song et al.   PLoS One

Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice

(2014) M. Garratt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Novel interactions between mitochondrial superoxide dismutases and the electron transport chain

(2013) Wichit Suthammarak et al.   AGING CELL

Manganese Superoxide Dismutase in Cancer Prevention

(2013) Delira Robbins et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases: A Perspective on Reactive Oxygen Species Production in Tumor Biology

(2013) Jennifer L. Meitzler et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations

(2013) Satoshi Tsunoda et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration

(2013) Amit R. Reddi et al.   CELL

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

(2013) Candice E. Paulsen et al.   CHEMICAL REVIEWS

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice

(2013) Yiqiang Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidant Sensing by Reversible Disulfide Bond Formation

(2013) Claudia M. Cremers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting SOD1 reduces experimental non–small-cell lung cancer

(2013) Andrea Glasauer et al.   JOURNAL OF CLINICAL INVESTIGATION

Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance

(2013) Kazuhiro Suetomi et al.   MITOCHONDRION

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Atomic-resolution monitoring of protein maturation in live human cells by NMR

(2013) Lucia Banci et al.   Nature Chemical Biology

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

SOD mRNA and MDA Expression in Rectus Femoris Muscle of Rats with Different Eccentric Exercise Programs and Time Points

(2013) Heng Zhao et al.   PLoS One

Molecular Strategies of the Caenorhabditis elegans Dauer Larva to Survive Extreme Desiccation

(2013) Cihan Erkut et al.   PLoS One

Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly

(2013) G. Favrin et al.   Scientific Reports

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

Cysteine residues as catalysts for covalent peptide and protein modification: a role for thiyl radicals?

(2012) Christian Schöneich   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Manganese superoxide dismutase regulation and cancer

(2012) Sanjit Kumar Dhar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial compartmentalization of redox processes

(2012) Ariel R. Cardoso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novelDrosophilaSOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease

(2012) Alicia M. Celotto et al.   Brain and Behavior

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Manganese superoxide dismutase, MnSOD and its mimics

(2011) Sumitra Miriyala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages

(2011) S. K. Dhar et al.   CANCER RESEARCH

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

The Role of Nitric Oxide on Endothelial Function

(2011) Dimitris Tousoulis et al.   Current Vascular Pharmacology

Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy

(2011) Lindsey R. Fischer et al.   EXPERIMENTAL NEUROLOGY

Identification ofDrosophilaSOD3 and its protective role against phototoxic damage to cells

(2011) Inhee Jung et al.   FEBS LETTERS

Superoxide dismutases: Ancient enzymes and new insights

(2011) Anne-Frances Miller   FEBS LETTERS

Role of Vascular Extracellular Superoxide Dismutase in Hypertension

(2011) Heinrich E. Lob et al.   HYPERTENSION

Analysis and Functional Prediction of Reactive Cysteine Residues

(2011) Stefano M. Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of the ATP-binding Cassette B7 (ABTM-1/ABCB7) Induces Oxidative Stress and Premature Cell Death inCaenorhabditis elegans

(2011) Pilar González-Cabo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

ROS signaling: the new wave?

(2011) Ron Mittler et al.   TRENDS IN PLANT SCIENCE

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans

(2011) Adolfo Sánchez-Blanco et al.   PLoS Genetics

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Is oxidative stress a therapeutic target in cardiovascular disease?

(2010) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans

(2010) Patricia Back et al.   EXPERIMENTAL GERONTOLOGY

Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster

(2010) Robin J. Mockett et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

(2010) Yiqiang Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy

(2010) Hirotomo Kuwahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Spontaneous skin damage and delayed wound healing in SOD1-deficient mice

(2010) Yoshihito Iuchi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

(2009) Candice E. Paulsen et al.   ACS Chemical Biology

Sod2 overexpression preserves myoblast mitochondrial mass and function, but not muscle mass with aging

(2009) Sukkyoo Lee et al.   AGING CELL

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of Hypertension and Peripheral Inflammation by Reduction of Extracellular Superoxide Dismutase in the Central Nervous System

(2009) Heinrich E. Lob et al.   HYPERTENSION

The Structure of Human Extracellular Copper–Zinc Superoxide Dismutase at 1.7 Å Resolution: Insights into Heparin and Collagen Binding

(2009) Svetlana V. Antonyuk et al.   JOURNAL OF MOLECULAR BIOLOGY

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SOD-1 Deletions in Caenorhabditis elegans Alter the Localization of Intracellular Reactive Oxygen Species and Show Molecular Compensation

(2009) S. Yanase et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans

(2009) Stephen Dingley et al.   MITOCHONDRION

Mutant mouse models of oxidative stress

(2009) Laurent Pouyet et al.   TRANSGENIC RESEARCH

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

Loss of Extracellular Superoxide Dismutase Leads to Acute Lung Damage in the Presence of Ambient Air

(2008) Maria Carolina Gongora et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Thiol-Based Redox Switches in Eukaryotic Proteins

(2008) Nicolas Brandes et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Signaling Across Cell Membranes

(2008) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mechanisms of Protein Damage Induced by Cysteine Thiyl Radical Formation

(2008) Christian Schöneich   CHEMICAL RESEARCH IN TOXICOLOGY

Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans

(2008) Yoko Honda et al.   EXPERIMENTAL GERONTOLOGY

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Early Mitochondrial Dysfunction in Long-livedMclk1+/-Mice

(2008) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

(2008) J. C. Juarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta

(2008) Yoshiaki Hitomi et al.   REDOX REPORT