Iron and ferroptosis: A still ill-defined liaison

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Emerging roles for lipids in non-apoptotic cell death

(2016) L Magtanong et al.   CELL DEATH AND DIFFERENTIATION

Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation

(2016) David A. Slatter et al.   Cell Metabolism

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

(2016) Bradley A. Carlson et al.   Redox Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice

(2015) Simone Hanna Brütsch et al.   ANTIOXIDANTS & REDOX SIGNALING

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

(2015) Jung Hoon Woo et al.   CELL

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

(2015) Sho Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Cerebellar Hypoplasia in Mice Lacking Selenoprotein Biosynthesis in Neurons

(2014) Eva K. Wirth et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids

(2014) Sean S. Davies et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Combined Deficiency in Glutathione Peroxidase 4 and Vitamin E Causes Multiorgan Thrombus Formation and Early Death in Mice

(2013) Markus Wortmann et al.   CIRCULATION RESEARCH

Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells

(2013) Xinqiang Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis

(2013) Corinne M. Spickett   Redox Biology

The Ubiquity of Iron

(2012) Perry A. Frey et al.   ACS Chemical Biology

Cell signalling by reactive lipid species: new concepts and molecular mechanisms

(2012) Ashlee Higdon et al.   BIOCHEMICAL JOURNAL

Import of phosphatidylserine to and export of phosphatidylethanolamine molecular species from mitochondria

(2012) Ville Kainu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Novel Keto-phospholipids Are Generated by Monocytes and Macrophages, Detected in Cystic Fibrosis, and Activate Peroxisome Proliferator-activated Receptor-γ

(2012) Victoria J. Hammond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells

(2012) Kazunori Yamanaka et al.   RSC Advances

Free Radical Oxidation of Polyunsaturated Lipids: New Mechanistic Insights and the Development of Peroxyl Radical Clocks

(2011) Derek A. Pratt et al.   ACCOUNTS OF CHEMICAL RESEARCH

Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance

(2011) Laurence Had-Aissouni   AMINO ACIDS

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells

(2011) Takashi Ueta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress

(2010) Aaron T. Jacobs et al.   ACCOUNTS OF CHEMICAL RESEARCH

Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

(2010) Lloyd T. Morgan et al.   BIOCHEMICAL JOURNAL

Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection

(2010) S. R. Clark et al.   BLOOD

Chemistry and biochemistry of lipid peroxidation products

(2010) F. Guéraud et al.   FREE RADICAL RESEARCH

System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

(2010) Pankaj Kumar Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

(2009) Eva K. Wirth et al.   FASEB JOURNAL

Importance of lipid metabolism for intracellular and mitochondrial membrane fusion/fission processes

(2009) Fabienne Furt et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

(2008) Angel Catalá   CHEMISTRY AND PHYSICS OF LIPIDS

Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation

(2008) Claus Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic Review Series: Glycerolipids.Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids

(2008) Jean E. Vance   JOURNAL OF LIPID RESEARCH

4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

(2007) G. Poli et al.   MEDICINAL RESEARCH REVIEWS