Article
Medicine, Research & Experimental
Ruonan Ma, Ling Fang, Lei Chen, Xiaonan Wang, Jing Jiang, Lizeng Gao
Summary: This study explores the role of iron in macrophages in suppressing intracellular bacteria. It reveals that the induction of ferroptotic stress and the inhibition of iron transport can lead to the death of intracellular bacteria. The findings suggest that targeting ferroptosis may provide a therapeutic approach for infectious diseases caused by intracellular pathogens.
Article
Biochemistry & Molecular Biology
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan
Summary: At physiological levels, selenium is involved in redox reactions and has potential anti-cancer effects. Selenium nanoparticles, coated with serum albumin or chitosan, enhance biocompatibility and bioavailability. In this study, selenium nanoparticles were found to regulate histone methylation in ovarian cancer cell models, leading to increased histone methylation at specific sites. This novel role of selenium in histone methylation is mediated by a decrease in S-adenosylhomocysteine, an endogenous inhibitor of lysine methyltransferases. These findings broaden our understanding of the action of selenium nanoparticles in cancer therapy and other applications.
Article
Cell Biology
Ramachandran Srinivasan, Hyo-Shim Han, Parthiban Subramanian, Anbazhagan Mageswari, Seong-Hoon Kim, Srikanth Tirumani, Vaibhav Kumar Maurya, Gothandam Kodiveri Muthukaliannan, Mohandass Ramya
Summary: The phenomenon of heat stress leading to ferroptosis-like cell death has recently been observed in bacteria as well as plant cells. However, the evidence of ferroptosis in microalgae remains unknown. This study investigated the induction of reactive oxygen species (ROS) and iron-dependent ferroptotic cell death in Chlamydomonas reinhardtii, comparing it with RSL3-induced ferroptosis. The results showed that both heat shock and RSL3 treatment triggered ferroptotic cell death with several characteristic biomarkers, indicating that ferroptotic cell death affects iron homeostasis and lipid peroxidation metabolism in Chlamydomonas.
Article
Biochemistry & Molecular Biology
Jung-A Choi, Elizabeth Hyeji Lee, Hanbyoul Cho, Jae-Hoon Kim
Summary: This study found that high-dose sodium selenite (SS) can inhibit the proliferation and induce cell death of ovarian cancer cells through increased reactive oxygen species (ROS) generation. High-dose SS also reduced the levels of glutathione peroxidase (GPx) and triggered lipid peroxidation and ferroptosis via dysregulated GPx4 pathways. In mouse models, high-dose SS significantly reduced tumor growth and weight, and decreased GPx4 expression in tumors. Therefore, high-dose SS is considered a potential chemotherapeutic agent for ovarian cancer, utilizing ferroptotic therapy by depleting glutathione and increasing ROS generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Saurabh Joshi, Saloni Agarwal, Apurva Panjla, Suresh Valiyaveettil, Subramaniam Ganesh, Sandeep Verma
Summary: This study reports the synthesis of purine derivatives for iron chelation and their efficacy in inhibiting ferroptosis. The compounds showed effective iron chelation and decreased reactive oxygen species concentration in cell cultures. Compound 2 exhibited better potency in preventing ferroptotic cell death compared to a commercially available iron chelator.
Article
Plant Sciences
Nam Khoa Nguyen, Juan Wang, Dongping Liu, Byung Kook Hwang, Nam-Soo Jwa
Summary: Rice ferritin 2 (OsFER2) is crucial for iron- and ROS-dependent ferroptotic cell death and defense response against the avirulent M. oryzae INA168. Its expression regulates iron and ROS accumulation, as well as the expression of defense-related genes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yafei Chen, Juan Wang, Nam Khoa Nguyen, Byung Kook Hwang, Nam Soo Jwa
Summary: OsNLP2 acts as a negative regulator of ferroptotic HR cell death and defense responses in rice, and its loss-of-function triggers the expression of defense-related genes, leading to broad-spectrum resistance to different strains of Magnaporthe oryzae.
Article
Biochemistry & Molecular Biology
Yuxin Gong, Ying Wu, Aman Khan, Peizhi Song, Zhenfei Wang, Hongyuhang Ni, Jing Ji, El-Sayed Salama, Pu Liu, Xiangkai Li
Summary: This study identified a high-efficiency selenite reductase, SerV01, which was introduced into the intestines of broilers to increase selenium content and improve antioxidant capability. The modified probiotics also increased the proportion of beneficial intestinal flora.
Article
Agronomy
Peter Ragalyi, Tuende Takacs, Aron Soos, Bela Kovacs, Mihaly Dernovics, Zdenko Loncaric, Peter Dobosy, Gyula Zaray, Mark Rekasi
Summary: This study examined the selenium species composition of four vegetables and found that the proportion of selenium species varies among different plant species and is influenced by soil types. Tomatoes and green peas had higher amounts of organic selenium, while cabbage and carrots had higher proportions of selenate.
Article
Materials Science, Multidisciplinary
Dan Liu, Lin Han, Ran Wei, Shixin Song, Jie Guan, Shuai Dong, David Tomanek
Summary: This study investigates the tunable electric polarization and electronic structure of quasi-two-dimensional allotropes of selenium. The results show that different allotropes exhibit different types of electric polarization and the polarization direction and magnitude can be changed by rotating the constituent chains. Additionally, rotating the chains can also alter the band gap and change it from indirect to direct.
PHYSICAL REVIEW MATERIALS
(2022)
Article
Environmental Sciences
Haibo Wang, Ruonan Jiang, Baiyi Wang, Shuhua Yao
Summary: The study focused on the iron-selenium coprecipitation method for selenium removal, finding that a two-step coprecipitation method with Fe/Se molar ratio of 4 was superior in terms of stability. Additionally, the incorporation of selenium into gypsum structure was observed at pH 8-10, indicating important implications for developing new technologies for efficient selenium removal.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Plant Sciences
Fengxian Yao, Li Wen, Rong Chen, Chao Du, Shiming Su, Mengmeng Yan, Zhonglan Yang
Summary: This study conducted a large-scale investigation in the largest navel orange-producing area in China and found that the average selenium content in the flesh was 4.92 μg/kg, with 7.93% of the navel oranges being Se-rich. There was a negative correlation between selenium, copper, and zinc. The study concluded that Se-enriched navel oranges have a higher potential for selenium dietary nutrition.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Sarmina Dangol, Nam Khoa Nguyen, Raksha Singh, Yafei Chen, Juan Wang, Hyeon-Gu Lee, Byung KooK Hwang, Nam-Soo Jwa
Summary: This study demonstrates the involvement of rice MAP kinase signaling cascades in iron- and ROS-dependent ferroptotic cell death responses to M. oryzae infection. OsMPK1 interacts with the WRKY90 transcription factor in the nucleus, and overexpression of OsMEK2 and OsMPK1 induces ferroptotic cell death in response to M. oryzae. These findings highlight the regulatory role of OsMEK2 and OsMPK1 in iron- and ROS-dependent cell death pathways in rice-M. oryzae interactions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Endocrinology & Metabolism
Florian Schepp, Undine Schubert, Janine Schmid, Susann Lehmann, Gladys Oluyemisi Latunde-Dada, Tugba Kose, Charlotte Steenblock, Stefan R. Bornstein, Andreas Linkermann, Barbara Ludwig
Summary: Ferroptosis, a non-apoptotic, iron-dependent cell death mechanism, plays a significant role in islet isolation and transplantation. Inhibiting this mechanism can protect islets from cell death and improve their function and survival.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Cell Biology
Shan Huang, Qimin Zhang, Manyu Zhao, Xing Wang, Yilei Zhang, Boyi Gan, Peijing Zhang
Summary: The study reveals the role of ZRANB1 in ferroptosis resistance and uncovers the mechanisms involving modulation of E3 ligase activity through an unconventional catalytic domain.
JOURNAL OF CELL BIOLOGY
(2023)