α-synuclein in the pathophysiology of Alzheimer’s disease

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

(2019) Alberto J. Espay et al.   NEUROLOGY

Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

(2018) Shahzad S. Khan et al.   ACTA NEUROPATHOLOGICA

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease

(2018) Min Shi et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Molecular biomarkers of Alzheimer's disease: progress and prospects

(2018) Tammaryn Lashley et al.   Disease Models & Mechanisms

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

(2018) Minee L. Choi et al.   FEBS Journal

A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer’s Disease and Mild Cognitive Impairment

(2018) Hua Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Multiple system atrophy and apolipoprotein E

(2018) Kotaro Ogaki et al.   MOVEMENT DISORDERS

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

(2018) Chao Peng et al.   NEUROBIOLOGY OF DISEASE

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Improving the identification of dementia with Lewy bodies in the context of an Alzheimer’s-type dementia

(2018) Alan J. Thomas et al.   Alzheimers Research & Therapy

Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic

(2018) Ross W. Paterson et al.   Alzheimers Research & Therapy

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Import and Export of Misfolded α-Synuclein

(2018) Lilia Rodriguez et al.   Frontiers in Neuroscience

Altered CSF Orexin and α-Synuclein Levels in Dementia Patients

(2018) Malin Wennström et al.   JOURNAL OF ALZHEIMERS DISEASE

α-Synuclein in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment

(2018) Ane Korff et al.   JOURNAL OF ALZHEIMERS DISEASE

Low Levels of Soluble NG2 in Cerebrospinal Fluid from Patients with Dementia with Lewy Bodies

(2018) Henrietta M. Nielsen et al.   JOURNAL OF ALZHEIMERS DISEASE

Spreading of Amyloid, Tau, and Microvascular Pathology in Alzheimer's Disease: Findings from Neuropathological and Neuroimaging Studies

(2018) Dietmar Rudolf Thal et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

(2018) Oeystein R. Brekk et al.   Scientific Reports

Rationally Designed Variants of α-Synuclein Illuminate Its in vivo Structural Properties in Health and Disease

(2018) Ulf Dettmer   Frontiers in Neuroscience

Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers

(2018) Andrea Vergallo et al.   Alzheimers & Dementia

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

(2018) Daniel Twohig et al.   Acta Neuropathologica Communications

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

(2017) Jinar Rostami et al.   JOURNAL OF NEUROSCIENCE

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

(2017) Giovanni B Frisoni et al.   LANCET NEUROLOGY

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

α-Synuclein promotes dilation of the exocytotic fusion pore

(2017) Todd Logan et al.   NATURE NEUROSCIENCE

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

(2017) Megan E. Larson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease

(2017) Nour K. Majbour et al.   Scientific Reports

Early- versus late-onset Alzheimer’s disease in clinical practice: cognitive and global outcomes over 3 years

(2017) Carina Wattmo et al.   Alzheimers Research & Therapy

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Cerebrospinal Fluid α-Synuclein Does Not Discriminate Between Dementia Disorders

(2017) Petra E. Spies et al.   JOURNAL OF ALZHEIMERS DISEASE

CSF α-Synuclein Does Not Discriminate Dementia with Lewy Bodies from Alzheimer's Disease

(2017) Fransje E. Reesink et al.   JOURNAL OF ALZHEIMERS DISEASE

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients

(2017) Birger Victor Dieriks et al.   Scientific Reports

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(2016) Bruno Dubois et al.   Alzheimers & Dementia

Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats

(2016) You-Cui Wang et al.   APOPTOSIS

Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer’s disease, mild cognitive impairment, or healthy controls: a two year follow-up study

(2016) Guro Berge et al.   BMC Neurology

Non-Demented Individuals with Alzheimer's Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies

(2016) Olga Zolochevska et al.   CURRENT PHARMACEUTICAL DESIGN

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

(2016) Takayuki Oikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model

(2016) Brian Spencer et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

(2016) Yuan Fu et al.   Molecular Neurodegeneration

Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain

(2016) Wen Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication

(2016) Irum Javaid Siddiqui et al.   Scientific Reports

Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology

(2015) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective

(2015) Matthew Baumgart et al.   Alzheimers & Dementia

Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders

(2015) Zheng-Yu Wang et al.   INTERNATIONAL PSYCHOGERIATRICS

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study

(2015) Niels Kruse et al.   NEUROBIOLOGY OF AGING

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

(2015) Ulf Dettmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

(2014) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels

(2014) Sylvie Slaets et al.   Alzheimers & Dementia

Convergence of pathology in dementia with Lewy bodies and Alzheimer’s disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease

(2014) Ashley R. Winslow et al.   BRAIN

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Apolipoprotein E  2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort

(2014) G. Berge et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Alpha-synuclein and tau: teammates in neurodegeneration?

(2014) Simon Moussaud et al.   Molecular Neurodegeneration

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease

(2014) Oskar Hansson et al.   Alzheimers Research & Therapy

The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis

(2014) Paul C Donaghy et al.   Alzheimers Research & Therapy

CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer’s disease

(2013) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

(2013) Michael W. Weiner et al.   Alzheimers & Dementia

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity

(2013) K. D. van Dijk et al.   EUROPEAN JOURNAL OF NEUROLOGY

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mysterious C-Terminal Tail of Alpha-Synuclein: Nanobody's Guess

(2013) David Eliezer   JOURNAL OF MOLECULAR BIOLOGY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Defining the Native State of α-Synuclein

(2013) Dennis Selkoe et al.   Neurodegenerative Diseases

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy

(2013) Malin Wennström et al.   PLoS One

The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease

(2013) Elisabeth Kapaki et al.   PLoS One

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems

(2013) Douglas Galasko et al.   Alzheimers Research & Therapy

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Incidence of Dementia With Lewy Bodies and Parkinson Disease Dementia

(2013) Rodolfo Savica et al.   JAMA Neurology

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Soluble  -Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology

(2012) M. E. Larson et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Function and Dysfunction of α-Synuclein: Probing Conformational Changes and Aggregation by Single Molecule Fluorescence

(2012) Adam J. Trexler et al.   MOLECULAR NEUROBIOLOGY

Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD

(2012) Brian Spencer et al.   MOLECULAR THERAPY

Impaired neurotransmission caused by overexpression of  -synuclein in nigral dopamine neurons

(2012) M. Lundblad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease

(2011) Fuyuki Tateno et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The amyloid cascade hypothesis has misled the pharmaceutical industry

(2011)   BIOCHEMICAL SOCIETY TRANSACTIONS

Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β

(2011) Fumitaka Kawakami et al.   FEBS Journal

The role of the C-terminus of human α-synuclein: Intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers

(2011) Dong-Pyo Hong et al.   FEBS LETTERS

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lipid-binding Domain of Wild Type and Mutant α-Synuclein

(2010) Elka R. Georgieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential levels of  -synuclein,  -amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease

(2010) K. Kasuga et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A Pathologic Cascade Leading to Synaptic Dysfunction in  -Synuclein-Induced Neurodegeneration

(2010) D. A. Scott et al.   JOURNAL OF NEUROSCIENCE

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Extracellular neurosin degrades α-synuclein in cultured cells

(2010) Harutsugu Tatebe et al.   NEUROSCIENCE RESEARCH

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Extrapyramidal Signs Before and After Diagnosis of Incident Alzheimer Disease in a Prospective Population Study

(2009) Florence Portet et al.   ARCHIVES OF NEUROLOGY

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

(2009) Adam J. Trexler et al.   BIOCHEMISTRY

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Functional dissection of the α-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219

(2009) Richard Lee Clough et al.   JOURNAL OF NEUROCHEMISTRY

Lewy Body Pathology in Normal Elderly Subjects

(2009) William R. Markesbery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Interplay of  -synuclein binding and conformational switching probed by single-molecule fluorescence

(2009) A. C. M. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY

Controlling the mass action of α-synuclein in Parkinson’s disease

(2008) Changyoun Kim et al.   JOURNAL OF NEUROCHEMISTRY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

(2008) Gilbert Gallardo et al.   NATURE NEUROSCIENCE

Cleavage of normal and pathological forms of α-synuclein by neurosin in vitro

(2008) Takashi Kasai et al.   NEUROSCIENCE LETTERS

Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss?

(2008) Annika Öhrfelt et al.   NEUROSCIENCE LETTERS

Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases

(2008) Igor F. Tsigelny et al.   PLoS One

GATA transcription factors directly regulate the Parkinson's disease-linked gene  -synuclein

(2008) C. R. Scherzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA