Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain

(2018) Penelope J. Hallett et al.   NEUROBIOLOGY OF AGING

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

(2018) Friederike Zunke et al.   NEURON

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

(2018) Sangjune Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease

(2018) Gyula Batta et al.   Scientific Reports

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

(2018) Elizabeth B. Moloney et al.   NEUROBIOLOGY OF DISEASE

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

(2017) Ulf Dettmer et al.   HUMAN MOLECULAR GENETICS

α-Synuclein promotes dilation of the exocytotic fusion pore

(2017) Todd Logan et al.   NATURE NEUROSCIENCE

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

(2017) Justin T. Rogers et al.   NEUROBIOLOGY OF AGING

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

(2017) Nadine Ait-Bouziad et al.   Nature Communications

Diaminodiphenyl sulfone–induced parkin ameliorates age-dependent dopaminergic neuronal loss

(2016) Yun-Il Lee et al.   NEUROBIOLOGY OF AGING

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

(2015) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

(2015) Ulf Dettmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Binds to Lipid Membrane Surfaces via Short Amphipathic Helices Located in Its Microtubule-Binding Repeats

(2014) Elka R. Georgieva et al.   BIOPHYSICAL JOURNAL

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease

(2014) Karen E. Murphy et al.   BRAIN

Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease

(2014) Lucilla Parnetti et al.   MOVEMENT DISORDERS

A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy

(2014) Franziska Richter et al.   Neurotherapeutics

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

(2013) Maria Xilouri et al.   BRAIN

A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

(2013) Michael A. Nalls et al.   JAMA Neurology

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Relation of neuropathology to cognition in persons without cognitive impairment

(2012) David A. Bennett et al.   ANNALS OF NEUROLOGY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

(2012) Penelope J. Hallett et al.   NEUROBIOLOGY OF DISEASE

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease

(2011) Charles Y. Shao et al.   ACTA NEUROPATHOLOGICA

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV  -Synucleinopathy

(2009) C. Y. Chung et al.   JOURNAL OF NEUROSCIENCE

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

β-Synuclein occursin vivoin lipid-associated oligomers and forms hetero-oligomers with α-synuclein

(2008) Eitan Israeli et al.   JOURNAL OF NEUROCHEMISTRY