α-Synuclein promotes dilation of the exocytotic fusion pore

Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease

(2016) Shounak Baksi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

(2016) Shuman Zhang et al.   Alzheimers Research & Therapy

α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles

(2015) Anthony R. Braun et al.   BIOPHYSICAL JOURNAL

Impaired maturation of large dense-core vesicles in muted-deficient adrenal chromaffin cells

(2015) Z. Hao et al.   JOURNAL OF CELL SCIENCE

Loss of δ-catenin function in severe autism

(2015) Tychele N. Turner et al.   NATURE

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Recycling Endosomes Undergo Rapid Closure of a Fusion Pore on Exocytosis in Neuronal Dendrites

(2014) D. Jullie et al.   JOURNAL OF NEUROSCIENCE

Metformin Protects Skeletal Muscle from Cardiotoxin Induced Degeneration

(2014) Francesca Langone et al.   PLoS One

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles

(2014) Hsueh-Cheng Chiang et al.   Nature Communications

New Fluorescent Substrate Enables Quantitative and High-Throughput Examination of Vesicular Monoamine Transporter 2 (VMAT2)

(2013) Gang Hu et al.   ACS Chemical Biology

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

α-Synuclein Can Inhibit SNARE-Mediated Vesicle Fusion through Direct Interactions with Lipid Bilayers

(2013) David C. DeWitt et al.   BIOCHEMISTRY

Self-Assembly of VPS41 Promotes Sorting Required for Biogenesis of the Regulated Secretory Pathway

(2013) Cédric S. Asensio et al.   DEVELOPMENTAL CELL

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Widespread Dysregulation of Peptide Hormone Release in Mice Lacking Adaptor Protein AP-3

(2013) Daniel W. Sirkis et al.   PLoS Genetics

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Munc13 controls the location and efficiency of dense-core vesicle release in neurons

(2012) Rhea van de Bospoort et al.   JOURNAL OF CELL BIOLOGY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

(2012) L. Shi et al.   SCIENCE

Perspectives on Kiss-and-Run: Role in Exocytosis, Endocytosis, and Neurotransmission

(2011) AbdulRasheed A. Alabi et al.   Annual Review of Physiology

Membrane Curvature Sensing by Amphipathic Helices

(2011) Martin Borch Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

v-SNARE Composition Distinguishes Synaptic Vesicle Pools

(2011) Zhaolin Hua et al.   NEURON

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vesicular Monoamine and Glutamate Transporters Select Distinct Synaptic Vesicle Recycling Pathways

(2010) B. Onoa et al.   JOURNAL OF NEUROSCIENCE

A Pathologic Cascade Leading to Synaptic Dysfunction in  -Synuclein-Induced Neurodegeneration

(2010) D. A. Scott et al.   JOURNAL OF NEUROSCIENCE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility

(2010) Vivek K. Unni et al.   PLoS One

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Differential Activity-Dependent Secretion of Brain-Derived Neurotrophic Factor from Axon and Dendrite

(2009) N. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release

(2009) Camin Dean et al.   NATURE NEUROSCIENCE

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

(2008) Steven L. Senior et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae

(2008) James H. Soper et al.   MOLECULAR BIOLOGY OF THE CELL