Role of Rab GTPases in Membrane Traffic and Cell Physiology

Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammals

(2014) Mitsunori Fukuda et al.   Autophagy

Assembly of the Biogenesis of Lysosome-related Organelles Complex-3 (BLOC-3) and Its Interaction with Rab9

(2010) Daniel P. Kloer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

(2010) F. J. Perez-Victoria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes

(2010) N. Vasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

(2010) Molly A. Lynch-Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

Defined Subunit Arrangement and Rab Interactions Are Required for Functionality of the HOPS Tethering Complex

(2010) Clemens W. Ostrowicz et al.   TRAFFIC

Comprehensive Screening for Novel Rab-Binding Proteins by GST Pull-Down Assay Using 60 Different Mammalian Rabs‡

(2010) Eiko Kanno et al.   TRAFFIC

Identification of Mutations in TRAPPC9, which Encodes the NIK- and IKK-β-Binding Protein, in Nonsyndromic Autosomal-Recessive Mental Retardation

(2009) Asif Mir et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Truncating Mutation of TRAPPC9 Is Associated with Autosomal-Recessive Intellectual Disability and Postnatal Microcephaly

(2009) Ganeshwaran H. Mochida et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase

(2009) Eoin E. Kelly et al.   BIOLOGY OF THE CELL

JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30

(2009) Chloe Thomas et al.   DEVELOPMENTAL BIOLOGY

The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

(2009) Thomas Wassmer et al.   DEVELOPMENTAL CELL

Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing

(2009) Orly Laufman et al.   EMBO JOURNAL

Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA

(2009) Hye-Young Suh et al.   EMBO JOURNAL

Molecular pathogenesis of Parkinson disease: insights from genetic studies

(2009) Thomas Gasser   EXPERT REVIEWS IN MOLECULAR MEDICINE

Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis

(2009) Marc Bitoun et al.   HUMAN MUTATION

Rab39a Binds Caspase-1 and Is Required for Caspase-1-dependent Interleukin-1β Secretion

(2009) Christine E. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

D-AKAP2 Interacts with Rab4 and Rab11 through Its RGS Domains and Regulates Transferrin Receptor Recycling

(2009) Christopher T. Eggers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation inCaenorhabditis elegans

(2009) Marija Sumakovic et al.   JOURNAL OF CELL BIOLOGY

Carpenter Syndrome

(2009) Pip Hidestrand et al.   JOURNAL OF CRANIOFACIAL SURGERY

Structural and Functional Analysis of the Globular Head Domain of p115 Provides Insight into Membrane Tethering

(2009) Yu An et al.   JOURNAL OF MOLECULAR BIOLOGY

The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia

(2009) Anke Schardt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dual Roles of the Mammalian GARP Complex in Tethering and SNARE Complex Assembly at the trans-Golgi Network

(2009) F. J. Perez-Victoria et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

(2009) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Rabex-5 Is a Rab22 Effector and Mediates a Rab22-Rab5 Signaling Cascade in Endocytosis

(2009) Huaiping Zhu et al.   MOLECULAR BIOLOGY OF THE CELL

Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

(2009) Daniel del Toro et al.   MOLECULAR BIOLOGY OF THE CELL

Varp Is a Novel Rab32/38-binding Protein That Regulates Tyrp1 Trafficking in Melanocytes

(2009) Kanako Tamura et al.   MOLECULAR BIOLOGY OF THE CELL

mTrs130 Is a Component of a Mammalian TRAPPII Complex, a Rab1 GEF That Binds to COPI-coated Vesicles

(2009) Akinori Yamasaki et al.   MOLECULAR BIOLOGY OF THE CELL

Vps41 Phosphorylation and the Rab Ypt7 Control the Targeting of the HOPS Complex to Endosome–Vacuole Fusion Sites

(2009) Margarita Cabrera et al.   MOLECULAR BIOLOGY OF THE CELL

Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34

(2009) Li Chen et al.   MOLECULAR MEMBRANE BIOLOGY

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

(2009) Uyen T T Nguyen et al.   Nature Chemical Biology

Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex

(2009) Arati Tripathi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease

(2009) Xueyi Li et al.   NEUROBIOLOGY OF DISEASE

Griscelli syndrome: a model system to study vesicular trafficking

(2009) Mireille Van Gele et al.   Pigment Cell & Melanoma Research

Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene

(2009) B. C. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway

(2009) F. E. Rivera-Molina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab35 Controls Actin Bundling by Recruiting Fascin as an Effector Protein

(2009) J. Zhang et al.   SCIENCE

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Modulation of membrane traffic between endoplasmic reticulum, ERGIC and Golgi to generate compartments for the replication of bacteria and viruses

(2009) Roberto Pierini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural Mechanisms for Regulation of Membrane Traffic by Rab GTPases

(2009) Meng-Tse Gabe Lee et al.   TRAFFIC

Charcot-Marie-Tooth Disease: A Clinico-genetic Confrontation

(2008) N. Barisic et al.   ANNALS OF HUMAN GENETICS

Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells

(2008) Noriyuki Nishimura et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Geranylgeranyl transferase type II inhibition prevents myeloma bone disease

(2008) Michelle A. Lawson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of the Rab7K157N mutant protein associated with Charcot–Marie-Tooth type 2B

(2008) Azzurra De Luca et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction

(2008) Makoto Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3

(2008) Margaret E. Graham et al.   BIOCHEMICAL JOURNAL

Rab10 in insulin-stimulated GLUT4 translocation

(2008) Hiroyuki Sano et al.   BIOCHEMICAL JOURNAL

COG defects, birth and rise!

(2008) François Foulquier   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structural Basis of Membrane Invagination by F-BAR Domains

(2008) Adam Frost et al.   CELL

The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes

(2008) Yiying Cai et al.   CELL

Ypt11 Functions in Bud-Directed Transport of the Golgi by Linking Myo2 to the Coatomer Subunit Ret2

(2008) Seisuke Arai et al.   CURRENT BIOLOGY

Retromer

(2008) Juan S Bonifacino et al.   CURRENT OPINION IN CELL BIOLOGY

The Salmonella-containing vacuole—Moving with the times

(2008) Olivia Steele-Mortimer   CURRENT OPINION IN MICROBIOLOGY

Chlamydia effector proteins and new insights into chlamydial cellular microbiology

(2008) Raphael H Valdivia   CURRENT OPINION IN MICROBIOLOGY

ICA69 is a novel Rab2 effector regulating ER–Golgi trafficking in insulinoma cells

(2008) Laura Buffa et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mechanisms of neurodegeneration in Huntington’s disease

(2008) Joana M. Gil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A unique residue in rab3c determines the interaction with novel binding protein Zwint-1

(2008) Thijs van Vlijmen et al.   FEBS LETTERS

Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form

(2008) P. Heidrych et al.   HUMAN MOLECULAR GENETICS

A Structural Model of the GDP Dissociation Inhibitor Rab Membrane Extraction Mechanism

(2008) Alexander Ignatev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab23 Regulates Differentiation of ATDC5 Chondroprogenitor Cells

(2008) Liu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6

(2008) Sophia Semerdjieva et al.   JOURNAL OF CELL BIOLOGY

Golgi coiled-coil proteins contain multiple binding sites for Rab family G proteins

(2008) Rita Sinka et al.   JOURNAL OF CELL BIOLOGY

Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase

(2008) Christopher L. Brett et al.   JOURNAL OF CELL BIOLOGY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

TbG63, a golgin involved in Golgi architecture in Trypanosoma brucei

(2008) I. B.-R. Ramirez et al.   JOURNAL OF CELL SCIENCE

Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection

(2008) M. V. Bujny et al.   JOURNAL OF CELL SCIENCE

Rab18 and Rab43 have key roles in ER-Golgi trafficking

(2008) S. Y. Dejgaard et al.   JOURNAL OF CELL SCIENCE

Functional Characterization of Rab7 Mutant Proteins Associated with Charcot-Marie-Tooth Type 2B Disease

(2008) M. R. Spinosa et al.   JOURNAL OF NEUROSCIENCE

Large Scale Screening for Novel Rab Effectors Reveals Unexpected Broad Rab Binding Specificity

(2008) Mitsunori Fukuda et al.   MOLECULAR & CELLULAR PROTEOMICS

Direct Interaction between a Myosin V Motor and the Rab GTPases Ypt31/32 Is Required for Polarized Secretion

(2008) Zhanna Lipatova et al.   MOLECULAR BIOLOGY OF THE CELL

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

HOPS Proofreads the trans-SNARE Complex for Yeast Vacuole Fusion

(2008) Vincent J. Starai et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple Rab GTPase Binding Sites in GCC185 Suggest a Model for Vesicle Tethering at the Trans-Golgi

(2008) Garret L. Hayes et al.   MOLECULAR BIOLOGY OF THE CELL

Ypt32p and Mlc1p bind within the vesicle binding region of the class V myosin Myo2p globular tail domain

(2008) Elena Caroli Casavola et al.   MOLECULAR MICROBIOLOGY

Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin

(2008) Hans Christian Hennies et al.   NATURE GENETICS

A function of huntingtin in guanine nucleotide exchange on Rab11

(2008) Xueyi Li et al.   NEUROREPORT

The Salmonella virulence protein SifA is a G protein antagonist

(2008) L. K. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRAPP Complex: Insights into its Architecture and Function

(2008) Michael Sacher et al.   TRAFFIC

Salmonella-Containing Vacuoles: Directing Traffic and Nesting to Grow

(2008) Malina A. Bakowski et al.   TRAFFIC

The ghost in the machine: small GTPases as spatial regulators of exocytosis

(2008) Hao Wu et al.   TRENDS IN CELL BIOLOGY

The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions

(2007) Rie Yamamura et al.   MOLECULAR BIOLOGY OF THE CELL

Deficiencies in subunits of the Conserved Oligomeric Golgi (COG) complex define a novel group of Congenital Disorders of Glycosylation

(2007) Renate Zeevaert et al.   MOLECULAR GENETICS AND METABOLISM

Rab6 family proteins interact with the dynein light chain protein DYNLRB1

(2007) Bas Wanschers et al.   CELL MOTILITY AND THE CYTOSKELETON