Targeting α-Synuclein in Parkinson’s Disease: Progress Towards the Development of Disease-Modifying Therapeutics
出版年份 2019 全文链接
标题
Targeting α-Synuclein in Parkinson’s Disease: Progress Towards the Development of Disease-Modifying Therapeutics
作者
关键词
-
出版物
DRUGS
Volume 79, Issue 8, Pages 797-810
出版商
Springer Science and Business Media LLC
发表日期
2019-04-13
DOI
10.1007/s40265-019-01104-1
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Gut-brain axis and the spread of α-synuclein pathology: vagal highway or dead end?
- (2019) David P. Breen et al. MOVEMENT DISORDERS
- The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration
- (2019) Danielle E. Mor et al. MOVEMENT DISORDERS
- The genetics of Parkinson disease
- (2018) Hao Deng et al. AGEING RESEARCH REVIEWS
- Is Parkinson’s disease a lysosomal disorder?
- (2018) Andrés D Klein et al. BRAIN
- Somatic copy number gains of α-synuclein (SNCA) in Parkinson’s disease and multiple system atrophy brains
- (2018) Katya Mokretar et al. BRAIN
- Immunologic treatment of Parkinson's disease
- (2018) Joseph Jankovic Immunotherapy
- Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic
- (2018) S. Pablo Sardi et al. MOVEMENT DISORDERS
- Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations
- (2018) Anthony E. Lang et al. MOVEMENT DISORDERS
- International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson's disease
- (2018) Susan H. Fox et al. MOVEMENT DISORDERS
- Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
- (2018) Chao Peng et al. NATURE
- LRRK2 kinase in Parkinson's disease
- (2018) Dario R. Alessi et al. SCIENCE
- Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti–α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease
- (2018) Joseph Jankovic et al. JAMA Neurology
- Progression in the LRRK2-Associated Parkinson Disease Population
- (2018) Rachel Saunders-Pullman et al. JAMA Neurology
- Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
- (2018) Jessika C. Bridi et al. Frontiers in Neuroscience
- Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
- (2018) Veronica Ghiglieri et al. Frontiers in Neurology
- Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
- (2018) Ariadna Recasens et al. Acta Neuropathologica Communications
- β2-adrenoreceptor medications and risk of Parkinson disease
- (2018) Susan Searles Nielsen et al. ANNALS OF NEUROLOGY
- A comprehensive analysis of SNCA -related genetic risk in sporadic parkinson disease
- (2018) Lasse Pihlstrøm et al. ANNALS OF NEUROLOGY
- Selective autophagy as a potential therapeutic target for neurodegenerative disorders
- (2018) Aurora Scrivo et al. LANCET NEUROLOGY
- Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound
- (2018) Kristiana Xhima et al. MOVEMENT DISORDERS
- Gene therapy for neurological disorders: progress and prospects
- (2018) Benjamin E. Deverman et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting prion-like protein spreading in neurodegenerative diseases
- (2018) Liam Chen et al. Neural Regeneration Research
- New Frontiers in Parkinson's Disease: From Genetics to the Clinic
- (2018) Lamya S. Shihabuddin et al. JOURNAL OF NEUROSCIENCE
- Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
- (2018) Saranna Fanning et al. MOLECULAR CELL
- Pathogenesis-targeted therapeutic strategies in Parkinson's disease
- (2018) Joseph Jankovic MOVEMENT DISORDERS
- The vermiform appendix impacts the risk of developing Parkinson’s disease
- (2018) Bryan A. Killinger et al. Science Translational Medicine
- Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
- (2018) Andreas Weihofen et al. NEUROBIOLOGY OF DISEASE
- Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
- (2017) Andrew B. West EXPERIMENTAL NEUROLOGY
- Therapeutic approaches to target alpha-synuclein pathology
- (2017) Patrik Brundin et al. EXPERIMENTAL NEUROLOGY
- A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments
- (2017) Jérôme Stirnemann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Parkinson's Disease Is Not Simply a Prion Disorder
- (2017) D. James Surmeier et al. JOURNAL OF NEUROSCIENCE
- Therapies targeting DNA and RNA in Huntington's disease
- (2017) Edward J Wild et al. LANCET NEUROLOGY
- Media hype: Patient and scientific perspectives on misleading medical news
- (2017) Israel Robledo et al. MOVEMENT DISORDERS
- Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
- (2017) J.A. Obeso et al. MOVEMENT DISORDERS
- T cells from patients with Parkinson’s disease recognize α-synuclein peptides
- (2017) David Sulzer et al. NATURE
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
- (2017) Yvette C Wong et al. NATURE MEDICINE
- Zeroing in on neurodegenerative α-synuclein
- (2017) Katie Kingwell NATURE REVIEWS DRUG DISCOVERY
- Vagotomy and Parkinson disease
- (2017) Bojing Liu et al. NEUROLOGY
- β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
- (2017) Shuchi Mittal et al. SCIENCE
- Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate
- (2017) Anna Migdalska-Richards et al. SYNAPSE
- c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential
- (2017) Saurav Brahmachari et al. Journal of Parkinsons Disease
- LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
- (2017) Hien Tran Zhao et al. Molecular Therapy-Nucleic Acids
- Exploring Braak’s Hypothesis of Parkinson’s Disease
- (2017) Carmen D. Rietdijk et al. Frontiers in Neurology
- The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
- (2017) David I. Finkelstein et al. Acta Neuropathologica Communications
- A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
- (2017) Jess-Karan S. Dhillon et al. PLoS One
- Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease
- (2017) Antonio Martin-Bastida et al. Scientific Reports
- Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients
- (2016) Morten Gersel Stokholm et al. ANNALS OF NEUROLOGY
- Survival and dementia inGBA-associated Parkinson's disease: The mutation matters
- (2016) Roberto Cilia et al. ANNALS OF NEUROLOGY
- Ade novocompound targeting α-synuclein improves deficits in models of Parkinson’s disease
- (2016) Wolfgang Wrasidlo et al. BRAIN
- New and emerging medical therapies in Parkinson’s disease
- (2016) Mitesh Lotia et al. EXPERT OPINION ON PHARMACOTHERAPY
- Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration
- (2016) Saurav Brahmachari et al. JOURNAL OF CLINICAL INVESTIGATION
- The relationship between glucocerebrosidase mutations and Parkinson disease
- (2016) Anna Migdalska-Richards et al. JOURNAL OF NEUROCHEMISTRY
- Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance
- (2016) Judith Blanz et al. JOURNAL OF NEUROCHEMISTRY
- Motor and nonmotor heterogeneity of LRRK2 -related and idiopathic Parkinson's disease
- (2016) Connie Marras et al. MOVEMENT DISORDERS
- Peripheral Synucleinopathy in Early Parkinson's Disease: Submandibular Gland Needle Biopsy Findings
- (2016) Charles H. Adler et al. MOVEMENT DISORDERS
- Targeting α-synuclein: Therapeutic options
- (2016) Benjamin Dehay et al. MOVEMENT DISORDERS
- First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
- (2016) Dale B. Schenk et al. MOVEMENT DISORDERS
- Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models
- (2016) Simona Petrucci et al. PARKINSONISM & RELATED DISORDERS
- The relationship between essential tremor and Parkinson's disease
- (2016) Mary Ann Thenganatt et al. PARKINSONISM & RELATED DISORDERS
- Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinsons disease
- (2016) A. Ghosh et al. Science Translational Medicine
- Nilotinib – Differentiating the Hope from the Hype
- (2016) Richard K. Wyse et al. Journal of Parkinsons Disease
- Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies
- (2016) Fernando Pagan et al. Journal of Parkinsons Disease
- Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates
- (2016) Timothy J. Collier et al. Frontiers in Neuroscience
- Vagotomy and subsequent risk of Parkinson's disease
- (2015) Elisabeth Svensson et al. ANNALS OF NEUROLOGY
- Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates
- (2015) Andreas A. Deeg et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Targeting α-synuclein as a therapeutic strategy for Parkinson’s disease
- (2015) Nada B Lawand et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model
- (2015) Alevtina D. Zharikov et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
- (2015) Benjamin Dehay et al. LANCET NEUROLOGY
- Development of Passive Immunotherapies for Synucleinopathies
- (2015) Ann-Louise Bergström et al. MOVEMENT DISORDERS
- Active immunization therapies for Parkinson's disease and multiple system atrophy
- (2015) Achim Schneeberger et al. MOVEMENT DISORDERS
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Spreading of pathology in neurodegenerative diseases: a focus on human studies
- (2015) Johannes Brettschneider et al. NATURE REVIEWS NEUROSCIENCE
- Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle
- (2015) S. Pablo Sardi et al. PROGRESS IN NEUROBIOLOGY
- Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and -synuclein
- (2015) M. Goedert SCIENCE
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
- (2015) Reina N. Fuji et al. Science Translational Medicine
- The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset
- (2014) Johannes Levin et al. ACTA NEUROPATHOLOGICA
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies
- (2014) Rajaraman Krishnan et al. JOURNAL OF MOLECULAR BIOLOGY
- Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
- (2014) D. Games et al. JOURNAL OF NEUROSCIENCE
- Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease
- (2014) Georgia S. Gaki et al. NEUROMOLECULAR MEDICINE
- Increased plasma oligomeric alpha-synuclein in patients with lysosomal storage diseases
- (2014) S.N. Pchelina et al. NEUROSCIENCE LETTERS
- Genetic Movement Disorders in Patients of Jewish Ancestry
- (2014) Rivka Inzelberg et al. JAMA Neurology
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- Glucocerebrosidase mutations and the pathogenesis of Parkinson disease
- (2013) Michelle S. Beavan et al. ANNALS OF MEDICINE
- Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease
- (2013) David Devos et al. ANTIOXIDANTS & REDOX SIGNALING
- Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance
- (2013) Michaeline L. Hebron et al. Autophagy
- Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease models
- (2013) M. L. Hebron et al. HUMAN MOLECULAR GENETICS
- Dangerous duet: LRRK2 and α-synuclein jam at CMA
- (2013) Zhenyu Yue et al. NATURE NEUROSCIENCE
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The link between the GBA gene and parkinsonism
- (2012) Ellen Sidransky et al. LANCET NEUROLOGY
- mTOR: on target for novel therapeutic strategies in the nervous system
- (2012) Kenneth Maiese et al. TRENDS IN MOLECULAR MEDICINE
- c-Abl in Neurodegenerative Disease
- (2011) Sarah D. Schlatterer et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease
- (2011) S. Z. Imam et al. JOURNAL OF NEUROSCIENCE
- Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond
- (2011) Tamar Shachar et al. MOVEMENT DISORDERS
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
- (2010) Alison L. McCormack et al. PLoS One
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
- (2010) H. S. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Structural Reorganization of α-Synuclein at Low pH Observed by NMR and REMD Simulations
- (2009) Kuen-Phon Wu et al. JOURNAL OF MOLECULAR BIOLOGY
- Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study
- (2009) J Benito-Leon et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- In vivo silencing of alpha-synuclein using naked siRNA
- (2008) Jada Lewis et al. Molecular Neurodegeneration
- Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood
- (2008) Robin Barbour et al. Neurodegenerative Diseases
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