c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential

Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes

(2017) Laura Scott et al.   EXPERIMENTAL NEUROLOGY

Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System

(2017) Vivek Lawana et al.   Journal of Neuroimmune Pharmacology

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

(2017) Dominika Truban et al.   Journal of Parkinsons Disease

The Microtubule-Associated Protein Tau is Also Phosphorylated on Tyrosine

(2017) Thibaud Lebouvier et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Phosphorylated at Tyrosine 394 is Found in Alzheimer's Disease Tangles and can be a Product of the Abl-Related Kinase, Arg

(2017) Matthew A. Tremblay et al.   JOURNAL OF ALZHEIMERS DISEASE

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations

(2016) Igor Dikiy et al.   ACS Chemical Biology

Off-Target Effects of BCR-ABL and JAK2 Inhibitors

(2016) Myke R. Green et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

(2016) Saurav Brahmachari et al.   JOURNAL OF CLINICAL INVESTIGATION

Harnessing Cerebrospinal Fluid Biomarkers in Clinical Trials for Treating Alzheimer's and Parkinson's Diseases: Potential and Challenges

(2016) Dana Kim et al.   Journal of Clinical Neurology

Cerebrospinal fluid biomarkers in Alzheimer's and Parkinson's diseases-From pathophysiology to clinical practice

(2016) Kaj Blennow et al.   MOVEMENT DISORDERS

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters

(2016) Yun-Kai Zhang et al.   Scientific Reports

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

(2016) Fernando Pagan et al.   Journal of Parkinsons Disease

Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics

(2015) Aaron M. Swomley et al.   ARCHIVES OF TOXICOLOGY

c-Abl–p38α signaling plays an important role in MPTP-induced neuronal death

(2015) R Wu et al.   CELL DEATH AND DIFFERENTIATION

A Ubl/ubiquitin switch in the activation of Parkin

(2015) V. Sauve et al.   EMBO JOURNAL

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Do CSF Biomarkers Predict Progression to Cognitive Impairment in Parkinson’s disease patients? A Systematic Review

(2015) Katherine Leaver et al.   NEUROPSYCHOLOGY REVIEW

Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution

(2015) Amanda Tse et al.   PLoS One

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

(2015) Daniel A. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluating the Promiscuous Nature of Tyrosine Kinase Inhibitors Assessed in A431 Epidermoid Carcinoma Cells by Both Chemical- and Phosphoproteomics

(2014) Piero Giansanti et al.   ACS Chemical Biology

Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway

(2014) James A. Olzmann et al.   Autophagy

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

(2014) Anne-Laure Mahul-Mellier et al.   HUMAN MOLECULAR GENETICS

The Capable ABL: What Is Its Biological Function?

(2014) J. Y. J. Wang   MOLECULAR AND CELLULAR BIOLOGY

Alpha-synuclein and tau: teammates in neurodegeneration?

(2014) Simon Moussaud et al.   Molecular Neurodegeneration

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

CSF biomarkers and clinical progression of Parkinson disease

(2014) S. Hall et al.   NEUROLOGY

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease

(2014) Georgia S. Gaki et al.   NEUROMOLECULAR MEDICINE

A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson’s disease

(2014) Akie Tanabe et al.   Frontiers in Cellular Neuroscience

The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

(2014) Senthilkumar S. Karuppagounder et al.   Scientific Reports

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

(2013) Yunjong Lee et al.   NATURE NEUROSCIENCE

Cerebrospinal fluid biomarkers in Parkinson disease

(2013) Lucilla Parnetti et al.   Nature Reviews Neurology

Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson’s Disease Model

(2013) Syed Z. Imam et al.   PLoS One

The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models

(2013) Hiroyasu Sato et al.   REVIEWS IN THE NEUROSCIENCES

Biochemical Increase in Phosphorylated Alpha-Synuclein Precedes Histopathology of Lewy-Type Synucleinopathies

(2012) Lih-Fen Lue et al.   BRAIN PATHOLOGY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Recent Advances in the Genetics of Parkinson's Disease

(2011) Ian Martin et al.   Annual Review of Genomics and Human Genetics

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Molecular Pathways: BCR-ABL

(2011) D. Cilloni et al.   CLINICAL CANCER RESEARCH

C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology

(2011) L. D. Estrada et al.   Current Alzheimer Research

c-Abl in Neurodegenerative Disease

(2011) Sarah D. Schlatterer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

(2011) S. Z. Imam et al.   JOURNAL OF NEUROSCIENCE

Synthesis and Characterization of a BODIPY Conjugate of the BCR-ABL Kinase Inhibitor Tasigna (Nilotinib): Evidence for Transport of Tasigna and Its Fluorescent Derivative by ABC Drug Transporters

(2011) Suneet Shukla et al.   MOLECULAR PHARMACEUTICS

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

(2011) Scott Ditch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxidative Stress in Parkinson's Disease

(2010) Chun Zhou et al.   Annals of the New York Academy of Sciences

c-Abl tyrosine kinase in the DNA damage response: cell death and more

(2010) V Meltser et al.   CELL DEATH AND DIFFERENTIATION

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity

(2010) J. Colicelli   Science Signaling

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

(2009) Thomas O'Hare et al.   CANCER CELL

A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells

(2009) U Rix et al.   LEUKEMIA

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits

(2008) Gonzalo I. Cancino et al.   BRAIN