Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

Altered Subcellular Distribution of c-Abl in Alzheimer's Disease

(2017) Zheng Jing et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Phosphorylated at Tyrosine 394 is Found in Alzheimer's Disease Tangles and can be a Product of the Abl-Related Kinase, Arg

(2017) Matthew A. Tremblay et al.   JOURNAL OF ALZHEIMERS DISEASE

α-Synuclein- and MPTP-Generated Rodent Models of Parkinsons Disease and the Study of Extracellular Striatal Dopamine Dynamics: A Microdialysis Approach

(2012) Gianfranco Bazzu et al.   CNS & Neurological Disorders-Drug Targets

Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)

(2012) Michaeline L. Hebron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration

(2012) Kristen A. Malkus et al.   NEUROBIOLOGY OF DISEASE

Impaired neurotransmission caused by overexpression of  -synuclein in nigral dopamine neurons

(2012) M. Lundblad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin ligase parkin modulates the execution of autophagy

(2011) Alexander M. Herman et al.   Autophagy

The Parkinson disease protein α-synuclein inhibits autophagy

(2011) Ashley R. Winslow et al.   Autophagy

BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

(2011) Tomasz Skorski   CHEMISTRY & BIOLOGY

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

c-Abl in Neurodegenerative Disease

(2011) Sarah D. Schlatterer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

(2011) S. Z. Imam et al.   JOURNAL OF NEUROSCIENCE

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

(2011) Evangelia Emmanouilidou et al.   PLoS One

β-Amyloid1–42Gene Transfer Model Exhibits Intraneuronal Amyloid, Gliosis, Tau Phosphorylation, and Neuronal Loss

(2010) G. William Rebeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

(2010) Preeti J Khandelwal et al.   Molecular Neurodegeneration

α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra

(2010) Alison L. McCormack et al.   PLoS One

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted therapies and autophagy: new insights from chronic myeloid leukemia

(2009) Paolo Salomoni et al.   Autophagy

Parkin promotes intracellular A 1-42 clearance

(2009) M. P. Burns et al.   HUMAN MOLECULAR GENETICS

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

c-Abl tyrosine kinase regulates cardiac growth and development

(2009) Z. Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits

(2008) Gonzalo I. Cancino et al.   BRAIN

Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression

(2008) F.-X. Mahon et al.   CANCER RESEARCH

Nilotinib: A second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia

(2008) David L. DeRemer et al.   CLINICAL THERAPEUTICS

Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities

(2008) Ashley D. Reynolds et al.   Journal of Neuroimmune Pharmacology

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Generation of a α-synuclein-based rat model of Parkinson's disease

(2007) Alessandra Recchia et al.   NEUROBIOLOGY OF DISEASE