Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State

(2012) Tobias Högen et al.   BIOPHYSICAL JOURNAL

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prerequisites to launch neuroprotective trials in Parkinson's disease: An industry perspective

(2012) Johannes R. Streffer et al.   MOVEMENT DISORDERS

Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes

(2012) Felix Schmidt et al.   PLoS One

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Diphenylpyrazole-Derived Compounds Increase Survival Time of Mice after Prion Infection

(2011) Fabienne Leidel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

From High-Throughput Cell Culture Screening to Mouse Model: Identification of New Inhibitor Classes against Prion Disease

(2011) Markus Geissen et al.   ChemMedChem

Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity

(2011) Mark J. Thompson et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Aminothiazoles as Therapeutic Leads for Prion Diseases

(2011) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

(2011) Sandra Hüls et al.   JOURNAL OF NEUROCHEMISTRY

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

(2010) Stephen Connelly et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

ST1859 reduces prion infectivity and increase survival in experimental scrapie

(2009) Laura Colombo et al.   ARCHIVES OF VIROLOGY

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Discovery of 2-Aminothiazoles as Potent Antiprion Compounds

(2009) S. Ghaemmaghami et al.   JOURNAL OF VIROLOGY

Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial

(2009) John Collinge et al.   LANCET NEUROLOGY

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

(2009) Gonzalo R. Lamberto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Misfolding and Neurodegeneration

(2008) Claudio Soto et al.   ARCHIVES OF NEUROLOGY

Cell-free propagation of prion strains

(2008) Joaquín Castilla et al.   EMBO JOURNAL

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2008) G Irvine et al.   MOLECULAR MEDICINE

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE