标题
Targeting α-synuclein: Therapeutic options
作者
关键词
-
出版物
MOVEMENT DISORDERS
Volume 31, Issue 6, Pages 882-888
出版商
Wiley
发表日期
2016-03-01
DOI
10.1002/mds.26568
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
- (2017) Mathieu Bourdenx et al. PROGRESS IN NEUROBIOLOGY
- Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases
- (2016) Mathieu Bourdenx et al. Autophagy
- Neurodegenerative Diseases: Expanding the Prion Concept
- (2015) Lary C. Walker et al. Annual Review of Neuroscience
- Commentary: Hot, Hotter, and Hottest Trends in α-Synuclein Research
- (2015) Vladimir N. Uversky CURRENT PROTEIN & PEPTIDE SCIENCE
- Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells
- (2015) Ola Awad et al. HUMAN MOLECULAR GENETICS
- MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
- (2015) Catherine L. Nezich et al. JOURNAL OF CELL BIOLOGY
- Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
- (2015) A. Siddiqui et al. JOURNAL OF NEUROSCIENCE
- Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
- (2015) Benjamin Dehay et al. LANCET NEUROLOGY
- A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
- (2015) Brian Spencer et al. Molecular Neurodegeneration
- Alpha-synuclein propagation: New insights from animal models
- (2015) Benjamin Dehay et al. MOVEMENT DISORDERS
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors
- (2015) Anke Van der Perren et al. NEUROBIOLOGY OF AGING
- Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
- (2015) Katrina L. Paumier et al. NEUROBIOLOGY OF DISEASE
- Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein
- (2015) Kiri Kilpatrick et al. PLoS One
- Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
- (2015) Brent J. Ryan et al. TRENDS IN BIOCHEMICAL SCIENCES
- Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
- (2015) Mathieu Bourdenx et al. Acta Neuropathologica Communications
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy
- (2014) Olivier Flabeau et al. MOVEMENT DISORDERS
- Multiple system atrophy: A prototypical synucleinopathy for disease-modifying therapeutic strategies
- (2014) Pierre-Olivier Fernagut et al. NEUROBIOLOGY OF DISEASE
- Lysosome: regulator of lipid degradation pathways
- (2014) Carmine Settembre et al. TRENDS IN CELL BIOLOGY
- Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death
- (2014) Mathieu Bourdenx et al. Frontiers in Neuroanatomy
- Pathological alpha-synuclein propagates through neural networks
- (2014) Masami Masuda-Suzukake et al. Acta Neuropathologica Communications
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- Prion-like spreading of pathological α-synuclein in brain
- (2013) Masami Masuda-Suzukake et al. BRAIN
- Lysosomal impairment in Parkinson's disease
- (2013) Benjamin Dehay et al. MOVEMENT DISORDERS
- Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?
- (2013) C. Warren Olanow et al. MOVEMENT DISORDERS
- Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
- (2013) David Freeman et al. PLoS One
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy
- (2013) P.O. Fernagut et al. SYNAPSE
- Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease
- (2012) M. Decressac et al. EXPERIMENTAL NEUROLOGY
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, -Synuclein Accumulation, and Neurotoxicity
- (2012) M. Usenovic et al. JOURNAL OF NEUROSCIENCE
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells
- (2012) Gabriel C. Baltazar et al. PLoS One
- Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
- (2012) B. Dehay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
- (2011) Diego L. Medina et al. DEVELOPMENTAL CELL
- E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment
- (2011) Kristel L. Emmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A tale on animal models of Parkinson's disease
- (2011) Erwan Bezard et al. MOVEMENT DISORDERS
- Prion-like acceleration of a synucleinopathy in a transgenic mouse model
- (2011) Anne-Laure Mougenot et al. NEUROBIOLOGY OF AGING
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- A Lysosomal Lair for a Pathogenic Protein Pair
- (2011) T. M. Dawson et al. Science Translational Medicine
- Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
- (2010) Ayse Ulusoy et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Endocytosis of nanomedicines
- (2010) Gaurav Sahay et al. JOURNAL OF CONTROLLED RELEASE
- Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors
- (2010) K. Ubhi et al. JOURNAL OF NEUROSCIENCE
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Applications of nanoparticles in ophthalmology
- (2010) Yolanda Diebold et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Functional Protein Delivery into Neurons Using Polymeric Nanoparticles
- (2009) Linda Hasadsri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
- (2009) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Is Parkinson's disease a prion disorder?
- (2009) C. W. Olanow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lrrk2 and α-synuclein are co-regulated in rodent striatum
- (2008) Marie Westerlund et al. MOLECULAR AND CELLULAR NEUROSCIENCE
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