标题
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-01-04
DOI
10.1038/s41573-018-0008-x
参考文献
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- (2012) Yi-Chun Chen et al. PARKINSONISM & RELATED DISORDERS
- Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis
- (2012) E Croze et al. PHARMACOGENOMICS JOURNAL
- Keap1 degradation by autophagy for the maintenance of redox homeostasis
- (2012) K. Taguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism
- (2011) Agnieszka Jazwa et al. ANTIOXIDANTS & REDOX SIGNALING
- Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
- (2011) Ralf A. Linker et al. BRAIN
- Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
- (2011) Abena S. Agyeman et al. BREAST CANCER RESEARCH AND TREATMENT
- Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
- (2011) Thomas W. Kensler et al. CARCINOGENESIS
- Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
- (2011) Hongting Zheng et al. DIABETES
- Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
- (2011) Stefan Freigang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
- (2011) Xiuwen Tang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers
- (2011) Yosuke Hirotsu et al. GENES TO CELLS
- Conserved Intramolecular Disulfide Bond Is Critical to Trafficking and Fate of ATP-binding Cassette (ABC) Transporters ABCB6 and Sulfonylurea Receptor 1 (SUR1)/ABCC8
- (2011) Yu Fukuda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism
- (2011) Emilia Kansanen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular mechanisms of cardiomyopathy
- (2011) Pamela A. Harvey et al. JOURNAL OF CELL BIOLOGY
- Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells
- (2011) Vineet Kumar et al. JOURNAL OF MEDICINAL CHEMISTRY
- New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
- (2011) Michael B. Sporn et al. JOURNAL OF NATURAL PRODUCTS
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Global quantification of mammalian gene expression control
- (2011) Björn Schwanhäusser et al. NATURE
- Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
- (2011) Gisa Ellrichmann et al. PLoS One
- Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- (2011) D. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model
- (2011) C. J. Harvey et al. Science Translational Medicine
- Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption
- (2011) Kai Connie Wu et al. TOXICOLOGICAL SCIENCES
- Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis
- (2011) Tej K. Pareek et al. Scientific Reports
- NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection
- (2010) Berenice Barajas et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
- (2010) Malin von Otter et al. BMC Medical Genetics
- Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation
- (2010) Jeong-Eun Kim et al. CELLULAR SIGNALLING
- Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice
- (2010) John W. Calvert et al. CIRCULATION
- The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy
- (2010) T. Jiang et al. DIABETES
- The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunction
- (2010) Bo Ding et al. FASEB JOURNAL
- Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease
- (2010) Cliona Stack et al. FREE RADICAL BIOLOGY AND MEDICINE
- p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
- (2010) Ashish Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcriptional Upregulation of Nrf2-Dependent Phase II Detoxification Genes in the Involved Epidermis of Vitiligo Vulgaris
- (2010) Vivek T. Natarajan et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression
- (2010) Ute Boettler et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
- (2010) Malin von Otter et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1
- (2010) K. Taguchi et al. MOLECULAR AND CELLULAR BIOLOGY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
- (2010) Constance L. Saw et al. MOLECULAR CARCINOGENESIS
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- (2010) M. McMahon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
- (2010) T. Ogura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration
- (2010) N. Wakabayashi et al. Science Signaling
- Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice
- (2009) Hirokazu Sugimoto et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression
- (2009) Tirumalai Rangasamy et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Deletion ofKeap1in the Lung Attenuates Acute Cigarette Smoke–Induced Oxidative Stress and Inflammation
- (2009) David J. Blake et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Nrf2 Protects Against Maladaptive Cardiac Responses to Hemodynamic Stress
- (2009) Jinqing Li et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
- (2009) Aimee L. Eggler et al. BIOCHEMICAL JOURNAL
- Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery
- (2009) D. R. Crooks et al. BLOOD
- Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
- (2009) A.Kenneth MacLeod et al. CARCINOGENESIS
- Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
- (2009) Melinda S. Yates et al. CARCINOGENESIS
- Nrf2: friend or foe for chemoprevention?
- (2009) T. W. Kensler et al. CARCINOGENESIS
- Role of microglial redox balance in modulation of neuroinflammation
- (2009) Nadia G Innamorato et al. CURRENT OPINION IN NEUROLOGY
- The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
- (2009) Antonio Cuadrado et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
- (2009) Sudhir Chowdhry et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
- (2009) Ana I. Rojo et al. GLIA
- Systems Biology Guided by Chinese Medicine Reveals New Markers for Sub-Typing Rheumatoid Arthritis Patients
- (2009) Herman van Wietmarschen et al. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
- Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement
- (2009) Hyman M. Schipper et al. JOURNAL OF NEUROCHEMISTRY
- Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
- (2009) Z. Sun et al. MOLECULAR AND CELLULAR BIOLOGY
- KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ
- (2009) Dung-Fang Lee et al. MOLECULAR CELL
- Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia
- (2009) Vincent Paupe et al. PLoS One
- Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
- (2009) Pei-Chun Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
- (2009) T. W. Sedlak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
- (2009) K. Kanninen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis
- (2009) Delinda A. Johnson et al. TOXICOLOGICAL SCIENCES
- Alveolar Oxidative Stress is Associated with Elevated Levels of Nonenzymatic Low-Molecular-Weight Antioxidants in Patients with Different Forms of Chronic Fibrosing Interstitial Lung Diseases
- (2008) Philipp Markart et al. ANTIOXIDANTS & REDOX SIGNALING
- Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
- (2008) Wen Lin et al. BIOCHEMICAL PHARMACOLOGY
- Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3
- (2008) Girish Rachakonda et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway
- (2008) Marc A. Riedl et al. CLINICAL IMMUNOLOGY
- The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population
- (2008) Cui-Ping Guan et al. EXPERIMENTAL DERMATOLOGY
- Nuclear Factor-Eythroid 2–Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury
- (2008) Jutta Lamlé et al. GASTROENTEROLOGY
- Nitro-fatty Acid Metabolome: Saturation, Desaturation, β-Oxidation, and Protein Adduction
- (2008) Volker Rudolph et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis
- (2008) M. R. Vargas et al. JOURNAL OF NEUROSCIENCE
- The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
- (2008) M. Kobayashi et al. MOLECULAR AND CELLULAR BIOLOGY
- Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice
- (2008) Thomas E. Sussan et al. PLoS One
- Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
- (2008) T. E. Sussan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
- (2008) D Goven et al. THORAX
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