Review
Biochemistry & Molecular Biology
Sergio Davinelli, Luciano Saso, Floriana D'Angeli, Vittorio Calabrese, Mariano Intrieri, Giovanni Scapagnini
Summary: This article reviews the potential molecular mechanisms by which astaxanthin (AST) regulates the transcription factors Nrf2 and NF-κB, which are involved in oxidative stress and inflammation. Additionally, it summarizes the current clinical studies elucidating how AST alleviates the etiopathogenesis of oxidative stress and inflammation.
Review
Cell Biology
Don A. Davies, Aida Adlimoghaddam, Benedict C. Albensi
Summary: Nrf2 impairments in neurodegenerative disorders, such as Alzheimer's disease, lead to oxidative stress, while Nrf2 activators can reverse memory and synaptic plasticity impairments associated with AD.
Article
Orthopedics
Peng Zhang, Yesheng Jin, Wei Xia, Xiaotong Wang, Zhiqiang Zhou
Summary: This study found that the active ingredient PHI from Forsythiae Fructus can alleviate IL-1 beta-induced inflammation cytokines and ECM degradation by activating Nrf2 and inhibiting the NF-kappa B pathway. This provides a biological rationale for the use of PHI as a potential candidate for OA treatment.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Nutrition & Dietetics
Yongfeng Zhang, Jie Hao, Zijian Liu, Zhige Li, Lirong Teng, Di Wang
Summary: This study investigated the regulatory effects of Inonotus hispidus (IH) on lipid metabolism in mice fed a high-fat diet (HFD). The results showed that IH could reverse the pathological state of the liver and fat, decrease the levels of LDL-C, TC, TG, and LEP, and increase the level of HDL-C in serum. Additionally, IH improved liver damage and modulated the gut microbiota. IH regulated the Nrf2/NF-κB signaling pathway and oxidative stress. These findings provide experimental evidence for the potential use of IH in obesity treatment.
Article
Biochemistry & Molecular Biology
Shujuan Li, Yan Li, Li Hou, Li Tang, Fang Gao
Summary: Forsythoside B hampers IL-1 beta-elicited rat chondrocyte apoptosis, oxidative stress, and facilitates proliferation. It suppresses the profiles of inflammatory factors and NOD-like receptor family pyrin domain containing 3 inflammasomes, as well as Kelch-like epichlorohydrin-associated protein-1 (Keap1) and nuclear factor-kappa B (NF-kappa B) phosphorylation, while promotes nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels. Furthermore, Forsythoside B mitigates cartilage damage and degeneration.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sonia Emanuele, Adriana Celesia, Antonella D'Anneo, Marianna Lauricella, Daniela Carlisi, Anna De Blasio, Michela Giuliano
Summary: The article discusses the roles of Nrf2 in both cancer and COVID-19, highlighting its protective function in normal cells but potential overstimulation in tumor cells. Nrf2 exhibits different mechanisms of action in cancer and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Shanshan Teng, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Lanzhou Li, Xiaowei Huang, Di Wang, Zhe Lin
Summary: The water-soluble Morchella esculenta polysaccharide 2 (MEP2) was purified and isolated from an aqueous extract of the Morchella esculenta fruiting bodies. MEP2, with a molecular weight of 959 kDa, has a glucan backbone and substitutions at the H-6 position. The study also revealed that MEP2 has hepatoprotective activity and regulates hepatic cytokines through the Usp10/NF-kappa B/Nrf2 signaling pathway.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Yong-er Chen, Shi-jie Xu, Ying-yu Lu, Shu-xian Chen, Xian-hua Du, Shao-zhen Hou, Hai-yang Huang, Jian Liang
Summary: The research demonstrates that asperuloside (ASP) has anti-inflammatory and antioxidant effects on DSS-induced chronic colitis, activating the Nrf2/HO-1 signaling pathway and inhibiting the NF-kappa B signaling pathway, making it a potential effective candidate for the treatment of IBD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Hua-Wen Meng, Zhen-Bao Shen, Xian-She Meng, Ze-Qun Yin, Xue-Rui Wang, Ting-Feng Zou, Zhi-Gang Liu, Shuang Zhang, Yuan -Li Chen, Xiao-Xiao Yang, Qing-Shan Li, Ya-Jun Duan
Summary: In this study, a series of novel oxadiazole derivatives were designed and synthesized, among which compound F12 showed the best pharmacological activity. Compound F12 improved the dysfunction in a mouse model of Parkinson's disease by reducing oxidative stress and inflammatory response, and could be a potential treatment for Parkinson's disease.
BIOORGANIC CHEMISTRY
(2023)
Review
Urology & Nephrology
Peter Stenvinkel, Glenn M. Chertow, Prasad Devarajan, Adeera Levin, Sharon P. Andreoli, Sripal Bangalore, Bradley A. Warady
Summary: Despite recent advances in the management of chronic kidney disease (CKD), morbidity and mortality rates in these patients remain high. Chronic inflammation, oxidative stress, hypoxia, senescence, and mitochondrial dysfunction are now recognized as key factors in the etiology and progression of CKD. Various mechanisms, such as NF-KB and Nrf2-mediated gene transcription, regulate the inflammatory response in CKD, impacting glomerular filtration rate (GFR) decline and eventual progression to end-stage kidney disease (ESKD) in various kidney diseases.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Yongpeng He, Shuaiqi Wang, Hao Sun, Yan Li, Jian Feng
Summary: This study demonstrates that naringenin (NG) exerts cardioprotective effects against diabetic cardiomyopathy by regulating oxidative stress and inflammation, reducing cardiac fibrosis and cardiomyocyte apoptosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Ali S. Alshehri, Attalla F. El-kott, Mohamed S. A. El-Gerbed, Ayman E. El-Kenawy, Ghadeer M. Albadrani, Heba S. Khalifa
Summary: The study evaluated the protective effect of kaempferol against cadmium chloride-induced liver damage through antioxidant and anti-inflammatory mechanisms, involving the upregulation of Nr12/HO-1 axis and suppression of NF-kappa B p65 and keap1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ying Fu, Yu Xiang, Ying Wang, Zhiwen Liu, Danyi Yang, Jie Zha, Chengyuan Tang, Juan Cai, Guochun Chen, Zheng Dong
Summary: This study uncovers the role of the STAT1/HMGB1/NF-?B pathway in chronic kidney problems after long-term use of cisplatin, providing new therapeutic targets for kidney protection in cancer patients receiving cisplatin chemotherapy.
Article
Nutrition & Dietetics
Mengyao Wang, Feng Zhang, Jie Zhou, Ke Gong, Shasha Chen, Xinran Zhu, Mengxue Zhang, Yajun Duan, Chenzhong Liao, Jihong Han, Zequn Yin
Summary: Licorice is a versatile herbal medicine and food, and glabridin (Gla) extracted from licorice root has various health benefits. The research discovered the positive effect of Gla in treating alcoholic liver disease (ALD) in mice and liver cells. Gla alleviated liver injury caused by ethanol, reduced inflammation and oxidative stress, and restored antioxidant enzyme activity. Gla also regulated specific molecular pathways involved in ALD. Overall, Gla shows promise as a potential health product or drug for ALD.
Article
Endocrinology & Metabolism
Xi Jiang, Qizhi Yan, Wendie Lao, Qian Lin, Haoran Cao, Lei Chen, Jin Chen, Xuefeng Yu, Fuhe Liu
Summary: This study aims to explore the effect of irisin on ethanol-induced behavioral deficits and investigate the underlying mechanisms. The results showed that chronic irisin treatment improved ethanol-induced depressive and anxiety-like behaviors, and this improvement was associated with the anti-inflammatory and antioxidant effects of irisin. The Nrf2-mediated antioxidative stress signaling pathway and NF-kappa B-mediated anti-inflammatory signaling pathway were involved in this protection.
METABOLIC BRAIN DISEASE
(2023)
Review
Nutrition & Dietetics
Lais de Souza Gouveia Moreira, Susane Fanton, Ludmila Cardozo, Natalia A. Borges, Emilie Combet, Paul G. Shiels, Peter Stenvinkel, Denise Mafra
Summary: Chronic kidney disease (CKD) is a disease characterized by systemic inflammation, oxidative stress, and gut dysbiosis, leading to metabolic disorders and increased risk of cardiovascular disease-associated death. Diet plays a crucial role in the prevention and management of CKD and its complications, and beetroot, a root vegetable rich in bioactive compounds such as nitrate, betaine, and betalain, has shown beneficial effects in CKD, including blood pressure reduction, anti-inflammatory properties, and antioxidant actions.
Article
Biochemistry & Molecular Biology
Denise Mafra, Livia Alvarenga, Milena B. Stockler-Pinto, Lia S. Nakao, Peter Stenvinkel, Paul G. Shiels
Summary: Bach1 forms nuclear heterodimers with sMaf, which antagonize the function of Nrf2. Studies have shown dysregulation of Nrf2 and Bach1 expression in chronic diseases. Therefore, investigating Nrf2 activators and Bach1 inhibitors as potential therapeutics for chronic diseases is necessary.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biochemistry & Molecular Biology
Karen Salve Coutinho-Wolino, Beatriz Oliveira da Cruz, Ludmila F. M. De F. Cardozo, Igor Alexandre Fernandes, Claudio Tinoco Mesquita, Peter Stenvinkel, Peter Bergman, Denise Mafra, Milena Barcza Stockler-Pinto
Summary: This study aimed to assess the effect of Brazil nut supplementation on TMAO levels and GPx activity in patients with CAD. It found that a 3-month Brazil nut supplementation did not change TMAO levels, but potentially increased GPx activity.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Isabelle C. V. S. Martins, Michel G. Maciel, Jose L. M. do Nascimento, Denise Mafra, Alexsandro F. Santos, Camila S. Padilha
Summary: The aim of this systematic review and meta-analysis was to evaluate the effects of anthocyanins-interventions on oxidative stress, inflammation, and lipid profile in patients undergoing hemodialysis. The results showed that anthocyanin intervention can reduce oxidative stress and inflammatory parameters, and improve lipid metabolism by increasing HDL cholesterol levels.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Urology & Nephrology
Denise Mafra, Livia Alvarenga, Marcia Ribeiro, Beatriz G. Baptista, Susane Fanton, Bruna R. Paiva, Liana Trugilho, Julie Ann Kemp, Marcelo Alves-Ribeiro, Ludmila F. M. F. Cardozo
Summary: This study aimed to evaluate the expression of Bach1 mRNA in different treatments for chronic kidney disease (CKD). The results showed that Bach1 mRNA expression was significantly higher in patients undergoing hemodialysis compared to peritoneal dialysis and nondialysis patients. This suggests that Bach1 may be a therapeutic target for regulating inflammation in CKD patients.
HEMODIALYSIS INTERNATIONAL
(2023)
Review
Food Science & Technology
Denise Mafra, Julie A. Kemp, Viviane de O. Leal, Ludmila Cardozo, Natalia A. Borges, Livia Alvarenga, Karla T. R. Teixeira, Peter Stenvinkel
Summary: Fish is a valuable source of nutrients and intake is associated with reduced cardiovascular risk, but recent studies have shown that it also contains TMAO, a toxin associated with cardiovascular diseases. TMAO levels are increased in patients with CKD, but the effects of a fish-rich diet on TMAO levels and cardiovascular outcomes have not been studied yet. This review explores the pros and cons of a fish-rich diet in CKD patients, an area that requires further research.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Nutrition & Dietetics
Karen S. Coutinho-Wolino, Manuela F. S. Melo, Jessica C. Mota, Denise Mafra, Jonas T. Guimaraes, Milena B. Stockler-Pinto
Summary: Gut dysbiosis, a common condition in chronic kidney disease (CKD) patients, can lead to uremic toxin production, inflammation, oxidative stress, and cardiovascular disease. Consuming berry fruits, rich in polyphenols and nutrients, has shown promise in positively influencing the gut microbiota and improving clinical outcomes in CKD. However, more research is needed to understand the mechanisms and determine the optimal amount of berries for these effects. Clinical studies are encouraged to further evaluate the potential benefits of berry fruits in CKD patients.
Article
Plant Sciences
Beatriz Germer Baptista, Susane Fanton, Marcia Ribeiro, Ludmila F. M. F. Cardozo, Bruna Regis, Livia Alvarenga, Marcelo Ribeiro-Alves, Andresa A. Berretta, Paul G. Shiels, Denise Mafra
Summary: The study aimed to evaluate the effects of propolis supplementation on inflammatory markers in peritoneal dialysis patients with chronic kidney disease. The results showed that propolis supplementation significantly reduced tumor necrosis factor-alpha levels and had a trend to increase the expression of nuclear factor erythroid-2-related factor 2.
Review
Nutrition & Dietetics
Lu Dai, Denise Mafra, Paul G. Shiels, Tilman M. Hackeng, Peter Stenvinkel, Leon J. Schurgers
Summary: Vitamin K and vitamin K-dependent proteins are associated with age-related diseases. The direct impact of vitamin K on cellular senescence is yet to be proven, but its status reflects the complex interactions between dietary intake, gut microbiome activity, and health. It is proposed to emphasize food quality and explore healthy eating patterns containing vitamin K rather than focusing on a single nutrient for dietary recommendations.
Article
Biochemistry & Molecular Biology
Bruna Cadete Martins, Alexandre Coelho Soares, Fabiane Ferreira Martins, Angela de Castro Resende, Kim Ohanna Pimenta Inada, Vanessa Souza-Mello, Nathalia Moura Nunes, Julio Beltrame Daleprane
Summary: This study aimed to evaluate the preventive and therapeutic effects of coffee consumption on molecular changes and adipose tissue remodeling in a murine model of high-fat diet-induced obesity. The results showed that the coffee prevention group had lower body mass and a better distribution of adipose tissue compared to the high-fat group. Both groups that received coffee showed improved glucose metabolism and attenuated adipose tissue inflammation. Coffee consumption also attenuated hepatic steatosis and inflammation. Preventive coffee consumption associated with a high-fat diet ameliorates the metabolic profile related to the development of obesity and its comorbidities.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Food Science & Technology
Denise Mafra, Julie A. Kemp, Natalia A. Borges, Michelle Wong, Peter Stenvinkel
Summary: Residual kidney function is associated with better quality of life and outcome for patients with chronic kidney disease (CKD), and strategies should be implemented to preserve kidney function. Gut dysbiosis due to increased uremic toxin production and endotoxemia is a major cause of kidney damage, and various strategies, including diet, medications, and faecal transplantation, have been proposed to modulate the gut microbiota in these patients. Modifying gut microbiota composition may mitigate chronic kidney damage and preserve residual kidney function, but the effects of diet on residual kidney function remain limited.
Review
Medicine, General & Internal
Beatriz G. Baptista, Ligia S. Lima, Marcia Ribeiro, Isadora K. Britto, Livia Alvarenga, Julie A. Kemp, Ludmila F. M. F. Cardozo, Andresa A. Berretta, Denise Mafra
Summary: Royal jelly is a bee product rich in bioactive components with therapeutic properties, such as antioxidants and anti-inflammatory compounds. It has been shown to have preventive effects on complications related to non-communicable diseases (NCDs) through its role in reducing inflammation, oxidative stress, and intestinal dysbiosis. Personalized use of royal jelly as a non-pharmacological therapy is recommended.
Review
Urology & Nephrology
Laiis de Souza Gouveia Moreira, Isabela de Souza da Costa Brum, Drielly C. M. de Vargas Reis, Liana Trugilho, Tuany R. Chermut, Marta Esgalhado, Ludmila F. M. F. Cardozo, Peter Stenvinkel, Paul G. Shiels, Denise Mafra
Summary: Cinnamon, a widely used spice and traditional herbal medicine, may have beneficial effects on cardiovascular disease, obesity, and diabetes. However, its effectiveness for chronic kidney disease (CKD) remains uncertain. Bioactive compounds in cinnamon can mitigate common complications in CKD patients, such as oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia. This narrative review explores the mechanisms by which cinnamon may alleviate CKD complications and its potential role as an additional nutritional strategy for this patient group.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2023)