Article
Virology
Yanhua Gao, Ira Bergman
Summary: Viral oncolytic immunotherapy is a promising approach for targeting and eliminating cancer cells using cancer-specific viruses. A new VSV, rrVSV-G, was developed by modifying the VSV-G glycoprotein to target the Her2/neu receptor, commonly found in breast cancer. This virus showed potent antitumor capabilities and can be combined with other oncolytic viruses for enhanced treatment results.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Yaoxing Wu, Shouheng Jin, Qingxiang Liu, Yu Zhang, Ling Ma, Zhiyao Zhao, Shuai Yang, Yi-Ping Li, Jun Cui
Summary: IRF3, a critical transcription factor in antiviral innate immune signaling, is regulated by CALCOCO2 and PSMD14. CALCOCO2 promotes autophagic degradation of IRF3, while PSMD14 prevents such degradation, maintaining IRF3 activity and fine-tuning immune response against viral infection.
Article
Plant Sciences
Shih-Chao Lin, Xiang Zhang, Caitlin W. Lehman, Han-Chi Pan, Ya Wen, Shiow-Yi Chen
Summary: Resveratrol, a natural phytochemical, shows promising efficacy in inhibiting vesicular stomatitis virus (VSV) infection, potentially serving as a veterinary therapeutic or prophylactic agent. It exerts a protective effect by increasing cell viability, reducing viral replication, and inhibiting VSV infection through suppression of the caspase cascade. These findings suggest the need for further investigation into the use of resveratrol as an antiviral treatment in veterinary medicine.
Article
Oncology
Jingshu Xiao, Jiaming Liang, Junjie Fan, Panpan Hou, Xiaodong Li, Haipeng Zhang, Kai Li, Lang Bu, Ping Li, Miao He, Yongheng Zhong, Liping Guo, Penghui Jia, Qiaoqiao Xiao, Junyu Wu, Hong Peng, Chunmei Li, Fan Xing, Deyin Guo
Summary: This study presents a promising strategy for the treatment of aggressive glioblastoma (GBM) by combining CDK4/6 inhibitors with oncolytic viruses (OV). CDK4/6 inhibition enhances the efficacy of OV by promoting autophagic degradation of MAVS, impairing antiviral responses, and amplifying oncolysis. Furthermore, CDK4/6 inhibitors and OV synergistically induce immuno-genic cell death and boost antitumor immunity, inhibiting tumor growth and prolonging survival in GBM models.
Article
Biotechnology & Applied Microbiology
Yanwei Chen, Shichuan Hu, Yongheng Shu, Zhongbing Qi, Bin Zhang, Yueting Kuang, Jinhu Ma, Ping Cheng
Summary: Solid tumors are characterized by abundant extracellular matrix and cancer-associated fibroblasts, impacting the vascular system and immune cells. The study demonstrates that the combination therapy of antifibrotic drug halofuginone with oncolytic virus significantly inhibits tumor growth and modulates the immunosuppressive tumor microenvironment.
HUMAN GENE THERAPY
(2022)
Article
Multidisciplinary Sciences
D. G. Roy, K. Geoffroy, M. Marguerie, S. T. Khan, N. T. Martin, J. Kmiecik, D. Bobbala, A. S. Aitken, C. T. de Souza, K. B. Stephenson, B. D. Lichty, R. C. Auer, D. F. Stojdl, J. C. Bell, M-C Bourgeois-Daigneault
Summary: Vaccination with oncolytic viruses co-administered with tumour antigenic peptides is as efficient as antigen-engineered oncolytic viruses, providing a potential alternative for personalized anti-cancer vaccines targeting patient-specific mutations.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Andrea Marzi, Allen Jankeel, Andrea R. Menicucci, Julie Callison, Kyle L. O'Donnell, Friederike Feldmann, Amanda N. Pinski, Patrick W. Hanley, Ilhem Messaoudi
Summary: The study demonstrates that the VSV-MARV vaccine showed rapid protective effects with high survival rates in nonhuman primates challenged with MARV. Transcriptional analysis indicated activation of B cells and antiviral defense after vaccination, with different immune responses observed in animals challenged at different time points post-vaccination. The data suggest that VSV-MARV could be a suitable fast-acting vaccine for emergency situations such as disease outbreaks in Africa.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Po-Yuan Ke
Summary: Autophagy regulates cellular metabolism and acts as a defense mechanism against viral infections. Recent studies have shown that virus-induced autophagy may promote viral replication by modulating host cellular processes, including the regulation of innate immunity mediated by RLR. This article provides an overview of the functional molecules and regulatory mechanisms of RLR antiviral immune response and autophagy, and summarizes the role of autophagy in regulating RLR antiviral signaling and the crosstalk between autophagy and RLR innate immunity.
Article
Cell Biology
Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui, Yi-Ping Li
Summary: This study demonstrates that NLRC5 exerts an antiviral effect by mediating the degradation of a multifunctional protein of DENV, providing a novel understanding of the regulatory network of NLRC5 in the host defense against virus infection.
Article
Cell Biology
Nanfang Peng, Helen H. H. Kang, Yan Feng, Alexander M. M. Minikes, Xuejun Jiang
Summary: Macroautophagy/autophagy is an important cellular survival mechanism in cancer, and its inhibition has potential therapeutic applications. This study found that inhibiting autophagy not only enhanced chemotherapy efficacy in glioblastoma (GBM) but also induced therapy-induced senescence of GBM cells. Additionally, autophagy inhibition altered the profile of senescence-associated secretory phenotype (SASP), leading to enhanced paracrine senescence, polarization of anti-tumor macrophages, and reduced recruitment of pro-tumor neutrophils. This study reveals the functional link between autophagy and senescence and suggests using autophagy blockage for senescence-mediated antitumor immunity.
Article
Pharmacology & Pharmacy
Wael L. Demian, Rajesh Abraham Jacob, Olga Cormier, Aisha Nazli, Matthew Melki, Akarin Asavajaru, Kaushal Baid, Ali Zhang, Matthew S. Miller, Charu Kaushic, Arinjay Banerjee, Karen Mossman
Summary: The study found that virus infection activates ASK1-related pathways, and the ASK1 inhibitor Selonsertib significantly reduces the replication of various viruses in human cell lines. However, differential effects of Selonsertib were observed in in vitro and in vivo hamster models, suggesting caution in predicting clinical and therapeutic outcomes in humans using rodent models.
ANTIVIRAL RESEARCH
(2023)
Article
Cell Biology
Bronwyn M. Gunn, Ryan P. McNamara, Lianna Wood, Sabian Taylor, Anush Devadhasan, Wenyu Guo, Jishnu Das, Avlant Nilsson, Amy Shurtleff, Sheri Dubey, Michael Eichberg, Todd J. Suscovich, Erica Ollmann Saphire, Douglas Lauffenburger, Beth -Ann Coller, Jakub K. Simon, Galit Alter
Summary: The 2013 Ebola epidemic in Central and West Africa marked the emergence of highly pathogenic viruses. The successful development of the Ebola vaccine will help control future outbreaks, but understanding how vaccine-induced antibodies protect against infection is crucial.
Article
Medicine, General & Internal
Kyle L. O'Donnell, Friederike Feldmann, Benjamin Kaza, Chad S. Clancy, Patrick W. Hanley, Paige Fletcher, Andrea Marzi
Summary: Marburg virus (MARV) is a highly pathogenic agent with no available treatments or vaccines. This study demonstrates that a vesicular stomatitis virus (VSV)-based vaccine expressing the MARV-Angola glycoprotein has a potential as a viable and fast-acting MARV vaccine candidate, providing uniform protection against the virus when administered in lower doses.
Article
Fisheries
Zuyun Wei, Qiao Wen, Wanru Li, Xiaoqin Yuan, Qiuling Fu, Zhengwei Cui, Xinhua Chen
Summary: The study demonstrates that ATG12 in large yellow croaker plays a role in promoting the formation of autophagosome membrane and enhances antiviral immunity by inducing both autophagy and type I interferon response.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Microbiology
Weixiao Zhang, Haiyan Shen, Menglu Wang, Xuelei Fan, Songqi Wang, Nile Wuri, Bin Zhang, Haiyan He, Chunhong Zhang, Zhicheng Liu, Ming Liao, Jianfeng Zhang, Yugu Li, Jianmin Zhang
Summary: The porcine epidemic diarrhea virus (PEDV) is a highly contagious enteropathogenic coronavirus that poses a serious threat to animal and human health. This study found that fangchinoline (Fan) can inhibit PEDV infection by blocking the autophagic flux in cells. These findings will contribute to the development of new strategies for the prevention and treatment of PEDV infection.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Zhang, Elena V. Knatko, Maureen Higgins, Sharadha Dayalan Naidu, Gillian Smith, Tadashi Honda, Laureano de la Vega, Albena T. Dinkova-Kostova
Summary: The overexpression of pirin in colorectal cancer is correlated with the activation of Nrf2 and increased expression of NQO1, but not with the expression of AKR1B10 and AKR1C1. Pirin is regulated by Nrf2 and its inhibition can decrease the viability of colorectal cancer cells.
Review
Biochemistry & Molecular Biology
Isabelle K. Vila, Soumyabrata Guha, Joanna Kalucka, David Olagnier, Nadine Laguette
Summary: STING, a major adaptor protein, not only plays a central role in controlling immune responses, but also plays a key role in controlling metabolic pathways. These findings deepen our understanding of STING's involvement in human pathologies.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Antonio Cuadrado, Albena T. Dinkova-Kostova, Giovanni E. Mann
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Multidisciplinary Sciences
Tim Vierbuchen, Shiuli Agarwal, John L. Johnson, Liraz Galia, Xuqiu Lei, Karina Stein, David Olagnier, Karoline Gaede, Christian Herzmann, Christian K. Holm, Holger Heine, Athma Pai, Aisling O'Hara Hall, Kasper Hoebe, Katherine A. Fitzgerald
Summary: The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon and cytokine expression in human myeloid cells. It binds to proteins involved in mRNA processing and alternative splicing, and its absence leads to altered splicing and reduced expression of the NR4A2 gene, resulting in elevated immune gene expression. Furthermore, elevated LUCAT1 levels are found in patients with inflammatory bowel disease, asthma, and chronic obstructive pulmonary disease, suggesting its role in the regulation of inflammatory diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pharmacology & Pharmacy
Albena T. Dinkova-Kostova, Ian M. Copple
Summary: Activation of NRF2 has the potential to address oxidative stress, inflammation, and metabolic imbalances in chronic pathologies. This article discusses the rationale for targeting NRF2, recent advances in drug development of NRF2 modulators, and the challenges in fully harnessing NRF2 as a therapeutic target.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lukas Gola, Laura Bierhansl, Julia Csatari, Christina B. Schroeter, Lisanne Korn, Venu Narayanan, Manuela Cerina, Sara Abdolahi, Anna Speicher, Alexander M. Hermann, Simone Koenig, Albena T. Dinkova-Kostova, Tawfeeq Shekh-Ahmad, Sven G. Meuth, Heinz Wiendl, Ali Gorji, Matthias Pawlowski, Stjepana Kovac
Summary: Hyperexcitability is associated with neuronal dysfunction, cellular death, and neurodegeneration. NOX4, an NADPH oxidase, is found to regulate reactive oxygen species (ROS) levels and calcium homeostasis, thereby preventing hyperexcitability and neuronal death. These findings suggest that NOX4 might have a crucial role in neurodegenerative diseases by acting as a potential redox regulator.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alison R. McNeilly, Jennifer L. Gallagher, Mark E. Evans, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Bernard T. Thorens, Albena Dinkova-Kostova, Jeffrey-T. Huang, Michael L. J. J. Ashford, Rory McCrimmon
Summary: Chronic hyperglycaemia and recurrent hypoglycaemia are independently associated with accelerated cognitive decline in type 1 diabetes. This study examines the hypothesis that post-hypoglycaemic hyperglycaemia exacerbates hippocampal oxidative stress and explores potential contributory mechanisms.
Article
Biochemistry & Molecular Biology
Kristiana M. Amirova, Petya A. Dimitrova, Milena N. Leseva, Ivanka K. Koycheva, Albena T. Dinkova-Kostova, Milen I. Georgiev
Summary: CDDO-Me regulates neutrophil function by reducing necrosis and cell apoptosis, decreasing CXCR4 expression, increasing Nrf2 levels, and improving histological score of joint damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Noemi Esteras, Thomas S. Blacker, Evgeny A. Zherebtsov, Olga A. Stelmashuk, Ying Zhang, W. Christian Wigley, Michael R. Duchen, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Summary: The transcription factor Nrf2 and its repressor Keap1 play a crucial role in cell stress adaptation by regulating gene expression related to cellular detoxification, antioxidant defense, and energy metabolism. This study investigated the impact of Nrf2 on glucose distribution and the connection between NADH production in energy metabolism and NADPH homeostasis using glio-neuronal cultures. The findings showed that Nrf2 activation enhances glucose uptake in neurons and astrocytes, with prioritized consumption for mitochondria-related energy production rather than NADPH synthesis in the pentose phosphate pathway.
Article
Oncology
Huy-Dung Hoang, Aida Said, Nasana Vaidya, Victoria H. Gilchrist, Kyle Malone, Usha Kabilan, Serena Topshee, Xiao Xiang, An-Dao Yang, David Olagnier, Karen Mossman, Shawn T. Beug, Seyed Mehdi Jafarnejad, Samuel T. Workenhe, Tyson E. Graber, Tommy Alain
Summary: The study demonstrates that incorporating the US11 5'leader into the GM-CSF transgene improves translation and enhances the therapeutic efficacy of oncolytic HSV1. Treatment with the US11 5'leader-GM-CSF oncolytic HSV1 shows superior antitumor immune activity and improved survival compared to the leaderless-GM-CSF HSV1 in a mouse model of colorectal cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Kit-Kay Mak, Zhang Shiming, Raghavendra Sakirolla, Madhu Katyayani Balijepalli, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika
Summary: This article describes the synthesis of new shogaol thiophene compounds (STCs) to enhance their stability, and demonstrates that these compounds are more effective in activating nuclear factor erythroid 2-related factor 2 (NRF2) and reducing inflammation compared to 6-shogaol.
Article
Biochemistry & Molecular Biology
Kit-Kay Mak, Shiming Zhang, Jestin Chellian, Zulkefeli Mohd, Ola Epemolu, Albena T. Dinkova-Kostova, Madhu Katyayani Balijepalli, Mallikarjuna Rao Pichika
Summary: The study evaluated the effect of swietenine in nonalcoholic fatty liver disease (NAFLD) in diabetic mice. Swietenine was found to reverse hepatic lipid accumulation and activate the Nrf2 antioxidant defense pathway, inhibiting lipogenesis. These findings suggest that swietenine has beneficial effects in diabetes-induced NAFLD.
Article
Biochemistry & Molecular Biology
Sharadha Dayalan Naidu, Plamena R. Angelova, Elena V. Knatko, Chiara Leonardi, Miroslav Novak, Laureano de la Vega, Ian G. Ganley, Andrey Y. Abramov, Albena T. Dinkova-Kostova
Summary: Transcription factor Nrf2 plays a crucial role in maintaining cellular redox homeostasis and mitochondrial health in lung cancer cells with loss-of-function Keap1 mutations.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jialin Feng, Oliver J. Read, Albena T. Dinkova-Kostova
Summary: Nuclear factor erythroid 2-related factor 2 (Nrf2) mediates cellular antioxidant response and plays a role in metabolism, inflammation, and immunity. Nrf2 activation is often exploited by cancer cells for survival and resistance to therapies. It can also occur in tumor-associated macrophages (TAMs) and contribute to an immunosuppressive tumor immune microenvironment (TIME). Cancer cell-derived metabolites activate Nrf2 and modulate the interaction between TIME and TAMs. Understanding the effects of Nrf2 in cancer presents opportunities for targeted therapy.
MOLECULES AND CELLS
(2023)
