Article
Rheumatology
Dinesh Khanna, Christopher P. Denton, Daniel E. Furst, Maureen D. Mayes, Marco Matucci-Cerinic, Vanessa Smith, Dick de Vries, Paul Ford, Yasmina Bauer, Matthew J. Randall, Mitra Ebrahimpoor, Laszlo Kupcsik, Pieter-Jan Stiers, Liesbeth Deberdt, Niyati Prasad, Sharlene Lim, Philippe Pujuguet, Sohail Ahmed
Summary: The study aimed to investigate the efficacy, safety, and tolerability of ziritaxestat in patients with early dcSSc. The results showed that ziritaxestat significantly reduced the modified Rodnan skin score compared to placebo and was well tolerated. Biomarker analysis suggested that ziritaxestat may reduce fibrosis. In conclusion, this study highlights the importance of ziritaxestat in improving skin involvement in patients with dcSSc.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mary Yinghua Zhang, Shuyi Fang, Hongyu Gao, Xiaoli Zhang, Dongsheng Gu, Yunlong Liu, Jun Wan, Jingwu Xie
Summary: This study identified the important role of amphiregulin (Areg) gene in skin fibrosis, with findings indicating that the Areg-EGFR-MEK signaling axis is critical for the development of fibrosis. By investigating the effects of Areg deficiency and inhibiting MEK, researchers demonstrated that blocking this signaling axis may be an effective treatment for scleroderma. The study highlights the potential of targeting Areg in the treatment of fibrotic diseases.
CELL AND BIOSCIENCE
(2021)
Article
Dermatology
Julien Seneschal, Alexandra Duplaine, Herve Maillard, Thierry Passeron, Nicolas Andreu, Regis Lassalle, Clelia Favary, Catherine Droitcourt, Alain Taieb, Khaled Ezzedine
Summary: In adult patients with facial vitiligo, twice-daily use of tacrolimus 0.1% ointment showed superior efficacy compared to the vehicle over 24 weeks of intervention and 24 weeks of follow-up. Therapeutic success rate was 65%, with only a 40% relapse rate at week 48.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Naoko Takamura, Ludivine Renaud, Willian Abraham da Silveira, Carol Feghali-Bostwick
Summary: Systemic sclerosis is an autoimmune disease characterized by vasculopathy and excessive fibrosis, with limited treatment options available. Research suggests that abnormal regulation of MCHR1 may play a role in the pathogenesis of SSc, and inhibiting MCHR1 could be a novel therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ming-Li Zou, Ying-Ying Teng, Zhong-hua Chen, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Jun-Jie Wu, Zheng-Dong Yuan, Xiao-Yu Tang, Shun Yu, Jun-Xing Ye, Xia Li, Xiao-Jin Zhou, Feng-Lai Yuan
Summary: Skin fibrosis is a common pathological feature of various diseases. The urokinase-type plasminogen activator (uPA) system, including uPA, urokinase plasminogen activator receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1), is upregulated in fibrotic diseases. The successful binding of uPA and uPAR activates the downstream peroxisome proliferator-activated receptor (PPAR) signaling pathway, reducing the proliferation, migration, and contraction of disease-derived fibroblasts and alleviating skin fibrosis. However, increased or robust upregulation of PAI-1 inhibits these effects, suggesting the involvement of PAI-1 in skin fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grondahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon
Summary: The use of letrozole during ovarian stimulation for IVF did not significantly decrease the proportion of women with premature progesterone levels above 1.5 ng/ml at the time of triggering final oocyte maturation. However, letrozole did significantly increase the proportion of women with mid-luteal progesterone levels above 30 ng/ml.
HUMAN REPRODUCTION
(2022)
Article
Surgery
Michel Prudhomme, Eric Rullier, Zaher Lakkis, Eddy Cotte, Yves Panis, Bernard Meunier, Philippe Rouanet, Jean-Jacques Tuech, Mehrdad Jafari, Guillaume Portier, Anne Dubois, Igor Sielezneff, Yann Parc, Jean-Luc Faucheron, Guillaume Meurette, Bernard Lelong, Guillaume Piessen, Mehdi Karoui, Pascale Fabbro-Peray, Christophe Demattei, Martin M. Bertrand
Summary: The study did not find evidence that systematic mesh implantation during primary colostomy creation was effective in preventing parastomal hernia. The positioning of the mesh in a retro-muscular position with a central incision for colon passage was not recommended as a method to prevent parastomal hernia. Optimization of mesh location and reinforcement material is recommended for future research.
Review
Biochemistry & Molecular Biology
Devis Benfaremo, Silvia Agarbati, Matteo Mozzicafreddo, Chiara Paolini, Silvia Svegliati, Gianluca Moroncini
Summary: Systemic sclerosis, also known as scleroderma or SSc, is a highly varied disease in terms of clinical presentation, disease progression, and treatment response. Recent advancements in skin molecular profiling technologies have enabled the identification of patient subgroups based on gene expression analysis. This narrative review provides an overview of the current status of skin gene expression analysis and emphasizes the benefits of stratifying patients based on their gene signatures. This stratification has the potential to lead to a precision medicine approach in the management of SSc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Young Gue Koh, Joon Seok, Jae Wan Park, Ka Ram Kim, Kwang Ho Yoo, Yong Joon Kim, Beom Joon Kim
Summary: This study aimed to evaluate the efficacy and safety of oral palmitoleic acid in improving skin barrier, elasticity, and wrinkle formation in adult women. The results showed that palmitoleic acid significantly improved skin hydration and transepidermal water loss. However, it did not show significant improvements in skin elasticity, surface roughness, eye wrinkle volume, wrinkle severity, and participant-assessed clinical improvement score.
Article
Pharmacology & Pharmacy
Jiansheng Li, Xue-qing Yu, Yang Xie, Shu-guang Yang, Limin Zhao, Miao Zhou, Yong Meng
Summary: The study aimed to evaluate the efficacy and safety of traditional Chinese medicine (TCM) treatment for idiopathic pulmonary fibrosis (IPF). The results showed that TCM treatment significantly reduced acute exacerbations, improved pulmonary function, health-related quality of life, exercise capacity, and symptoms, with acceptable side-effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yoon-Koo Kang, Suzanne George, Robin L. Jones, Piotr Rutkowski, Lin Shen, Olivier Mir, Shreyaskumar Patel, Yongjian Zhou, Margaret von Mehren, Peter Hohenberger, Victor Villalobos, Mehdi Brahmi, William D. Tap, Jonathan Trent, Maria A. Pantaleo, Patrick Schoeffski, Kevin He, Paggy Hew, Kate Newberry, Maria Roche, Michael C. Heinrich, Sebastian Bauer
Summary: Avapritinib, a potent inhibitor of KIT and PDGFRA mutant kinases, showed clinical activity in GISTs with specific mutations. The VOYAGER study comparing avapritinib and regorafenib in advanced GIST patients did not find a significant difference in median progression-free survival, but showed similar overall survival and safety profiles between the two treatments.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Rheumatology
Corrado Campochiaro, Giacomo De Luca, Maria-Grazia Lazzaroni, Giuseppe Armentaro, Amelia Spinella, Barbara Vigone, Barbara Ruaro, Anna Stanziola, Devis Benfaremo, Enrico De Lorenzis, Beatrice Moccaldi, Silvia Laura Bosello, Giovanna Cuomo, Lorenzo Beretta, Elisabetta Zanatta, Dilia Giuggioli, Nicoletta Del Papa, Paolo Airo, Marco Confalonieri, Gianluca Moroncini, Lorenzo Dagna, Marco Matucci-Cerinic
Summary: In this real-life study, the efficacy and safety of Nintedanib in treating SSc-ILD were evaluated. The results showed that Nintedanib, in combination with immunosuppressants, could stabilize lung function and reduce lung progression. However, gastrointestinal side effects were observed frequently.
Review
Allergy
Yasuhito Hamaguchi
Summary: Drug-induced scleroderma-like lesion refers to skin sclerotic lesions similar to systemic sclerosis or morphea induced by drug administration. Various drugs can cause this condition, including chemotherapeutic agents and immune checkpoint inhibitors. Unlike systemic sclerosis, drug-induced scleroderma-like lesion does not include Raynaud's phenomenon, nail-fold capillary abnormality, and organ involvement. It is important to consider the possibility of drug-induced sclerotic lesion when treating patients with skin sclerosis.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Masataka Kuwana, Minoru Hasegawa, Ryosuke Fukue, Yuichiro Shirai, Osamu Ishikawa, Hirahito Endo, Fumihide Ogawa, Daisuke Goto, Yasushi Kawaguchi, Shinichi Sato, Hironobu Ihn, Kazuhiko Takehara
Summary: The study aimed to identify initial parameters predicting worsening skin thickening in dcSSc patients in Japan. Short disease duration, low mRSS values, absence of nailfold bleeding, arthritis, and high erythrocyte sedimentation rate at diagnosis were identified as predictors of subsequent worsening of skin thickness. A predictive model showed that patients with disease duration <= 12 months and mRSS <= 19 had a risk of mRSS worsening within one year.
MODERN RHEUMATOLOGY
(2021)
Article
Integrative & Complementary Medicine
Mohsen Zabihi, Bahareh Hatefi, Mohammad Ebrahimzadeh Ardakani, Ali Mohammad Ranjbar, Farhad Mohammadi
Summary: This study investigated the healing effect of hydroalcoholic extract of licorice root on the wound healing process caused by second-degree burns. The results showed that patients using the hydrogel containing licorice root hydroalcoholic extract had significantly less inflammation, redness, pain, and burning compared to the control group, and the healing process was significantly faster.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Letter
Rheumatology
Renaud Felten, Jacques-Eric Gottenberg
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Michael Hughes, Suiyuan Huang, Juan Jose Alegre-Sancho, Patricia E. Carreira, Merete Engelhart, Eric Hachulla, Joerg Henes, Eduardo Kerzberg, Maria Rosa Pozzi, Gabriela Riemekasten, Vanessa Smith, Gabriella Szucs, Marie Vanthuyne, Elisabetta Zanatta, Oliver Distler, Armando G. Gabrielli, Anna-Maria Hoffmann-Vold, Virginia D. Steen, Dinesh Khanna
Summary: This study aimed to investigate the prevalence and characteristics of late skin fibrosis in systemic sclerosis (SSc). The study found that late skin fibrosis is not uncommon in SSc, and different patterns of development exist among patients. Patients with lower baseline mRSS and lcSSc are more likely to develop late skin fibrosis. Anti-Scl-70 is associated with progression from lcSSc to dcSSc, while anticentromere antibodies have a protective effect.
Article
Dermatology
Angela L. Bosma, Annelie H. Musters, Manja Bloem, Louise A. A. Gerbens, Maritza A. Middelkamp-Hup, Eva Haufe, Jochen Schmitt, Sebastien Barbarot, Julien Seneschal, Delphine Staumont-Salle, Emma K. Johansson, Maria Bradley, Laura B. von Kobyletzki, Ida Vittrup, Iben Frier Ruge, Jacob P. Thyssen, Christian Vestergaard, Marina de Vega, Ignacio Garcia-Doval, Andrea Chiricozzi, Luca Stingeni, Piergiacomo Calzavara-Pinton, Michael R. Ardern-Jones, Nick J. Reynolds, Carsten Flohr, Phyllis Spuls
Summary: The TREAT Registry Taskforce is a collaborative network collecting real-world data on atopic eczema patients. This study provides an overview of the eight established TREAT registries and examines the overlap and pooling ability of their datasets. The results show that pooled analyses can be performed on multiple important domain items, enabling future comparative analyses.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Rheumatology
Yann Nguyen, Cecile M. Yelnik, Nathalie Morel, Romain Paule, Romain Stammler, Leo Placais, Karim Sacre, Bertrand Godeau, Helene Maillard, David Launay, Sandrine Morell-Dubois, Anastasia Dupre, Guillaume Lefevre, Cecile Devloo, Virginie Dufrost, Ygal Benhamou, Herve Levesque, Gaelle Leroux, Jean-Charles Piette, Luc Mouthon, Eric Hachulla, Marc Lambert, Veronique Le Guern, Nathalie Costedoat-Chalumeau
Summary: This study used unsupervised clustering analysis to identify four homogeneous phenotypic subgroups among APS patients, primarily involving venous, arterial, SLE or other autoimmune disease-associated, and arterial microthrombotic phenotypes. These findings may be explained by heterogeneous pathophysiological mechanisms.
Article
Rheumatology
Michele Iudici, Denis Mongin, Elise Siegert, Patricia E. Carreira, Joerg Distler, Joerg Henes, Elisabetta Zanatta, Eric Hachulla, Giacomo De Luca, Carolina de Souza Mueller, Tania Santiago, Jose-Luis Tandaipan, Breno Valdetaro Bianchi, Maria De Santis, Anna-Maria Hoffmann-Vold, Armando Gabrielli, Oliver Distler, Delphine Sophie Courvoisier
Summary: The study aimed to estimate the prevalence of long-term exposure to glucocorticoids (GCs) among SSc patients and identify factors associated with prescribing practices over time and across countries. The results showed that the utilization of GCs is widespread and long-term in SSc patients, with significant variations between countries and within-country. However, there has been a gradual decrease in their utilization.
Article
Rheumatology
Alain Lescoat, Doerte Huscher, Nils Schoof, Paolo Airo, Jeska De Vries-Bouwstra, Gabriela Riemekasten, Eric Hachulla, Andrea Doria, Edoardo Rosato, Nicolas Hunzelmann, Carlomaurizio Montecucco, Armando Gabrielli, Anna-Maria Hoffmann-Vold, Oliver Distler, Jennifer Ben Shimol, Maurizio Cutolo, Yannick Allanore
Summary: The prevalence and characteristics of SSc-associated interstitial lung disease (SSc-ILD) vary between geographical regions. This study aimed to explore the differences in prevalence, phenotype, treatment, and prognosis in patients with SSc-ILD from different regions in the EUSTAR database. The results showed significant variations in clinical characteristics, survival rates, and treatment approaches among different regions.
Article
Immunology
Cloe Comarmond, Elodie Drumez, Julien Labreuche, Eric Hachulla, Thierry Thomas, Rene-Marc Flipo, Raphaelle Seror, Jerome Avouac, Nathalie Balandraud, Renaud Desbarbieux, Renaud Felten, Melanie Gilson, Marie-Hlene Guyot, Ambre Hittinger-Roux, Thao Pham, Myriam Renard, Nicolas Roux, Vincent Sobanski, Anne Tournadre, Christophe Richez, Patrice Cacoub
Summary: This study investigated whether RMD patients receiving anti-IL6 therapy have less severe forms of COVID-19 and better outcomes. Retrospective analysis of the French RMD COVID-19 cohort data showed that the severity of COVID-19 was lower in the anti-IL6 group, but there were no significant differences in the evolution of COVID-19 between the groups.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Letter
Dermatology
J. Nasseh, A. Brun, V. Theret, J. Ramspacher, M. Severino-Freire, D. Coustou, C. Bulai Livideanu, M. Tauber, M. C. Marguery, C. Paul
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
B. Halioua, C. Taieb, J. Clarke, C. Ribeyre, S. Merhand, A. L. Demessant-Flavigny, J. Seneschal
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Mathilde Guyon, Ribal Merhi, Nicolas Andreu, Katia Boniface, Julien Seneschal
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Nanja van Geel, Jolien Duponselle, Liesbeth Delbaere, Sandrine Herbelet, Viktoria Eleftheriadou, Khaled Ezzedine, Maxine Forman, Amit Garg, Iltefat H. Hamzavi, Julien Seneschal, Phyllis Spuls, Caroline B. Terwee, Albert Wolkerstorfer, Reinhart Speeckaert, Amit G. Pandya
Summary: This article reviews the importance of clinician-reported outcome measures (ClinROMs) in assessing vitiligo and describes 14 different ClinROMs that can be used to measure vitiligo extent, repigmentation, and activity. The choice of an appropriate ClinROM depends on practical strengths and limitations as well as the research question and setting.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Rheumatology
Amelie Nicolas, Sylvie Leroy, Luc Mouthon, Yurdagul Uzunhan, Vincent Cottin, Arsene Mekinian, Viviane Queyrel, Eric Hachulla, Benoit Gachet, David Launay, Nihal Martis
Summary: This study provides an overview of the diagnostic approaches, follow-up, and treatment strategies used in France for the management of SSc-associated ILD. The results highlight the heterogeneity and gaps in current clinical practices, calling for improvement and standardization.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Meeting Abstract
Rheumatology
Mickael Essouma, Jean Jacques Noubiap, Madeleine Singwe-Ngandeu, Eric Hachulla
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Louai Zaidan, Noemie Le Gouellec, Eric Hachulla, Luc Mouthon, Francois Jerome Authier
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Federica Cacciamani, Ariane Bercu, Vincent Bouteloup, Leslie Grasset, Vincent Planche, Genevieve Chene, Carole Dufouil
Summary: There is heterogeneity in subjective perception of cognitive changes, despite similar objective cognitive trajectories. This perception is explained by both AD-related and, more robustly, non-AD-related factors. These findings deepen our understanding of the multifaceted nature of subjective cognitive complaints in individuals at risk for dementia and highlight the importance of considering a range of factors when interpreting cognitive complaints.
ALZHEIMERS RESEARCH & THERAPY
(2023)