Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37

G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia

(2017) Sarah Jolly et al.   GLIA

Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders

(2017) Beihui Liu et al.   GLIA

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant

(2017) Michelle M. Giddens et al.   NEUROBIOLOGY OF DISEASE

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines

(2017) Jo Lynne Harenza et al.   Scientific Data

An 18-mer Peptide Derived from Prosaposin Ameliorates the Effects of Aβ1–42 Neurotoxicity on Hippocampal Neurogenesis and Memory Deficit in Mice

(2016) Hui-ling Gao et al.   JOURNAL OF ALZHEIMERS DISEASE

The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding

(2016) S. Orvokki Mattila et al.   JOURNAL OF CELL SCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors

(2016) Tony Ngo et al.   Nature Chemical Biology

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Metalloprotease cleavage of the N terminus of the orphan G protein–coupled receptor GPR37L1 reduces its constitutive activity

(2016) James L. J. Coleman et al.   Science Signaling

Metalloprotease cleavage of the N terminus of the orphan G protein–coupled receptor GPR37L1 reduces its constitutive activity

(2016) James L. J. Coleman et al.   Science Signaling

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1

(2015) Nicola J. Smith   Frontiers in Pharmacology

Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

(2015) Jeffrey Klarenbeek et al.   PLoS One

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Attenuation of MPTP/MPP+ toxicity in vivo and in vitro by an 18-mer peptide derived from prosaposin

(2013) H.L. Gao et al.   NEUROSCIENCE

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

(2013) Rebecca C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain

(2010) Beihui Liu et al.   BMC MOLECULAR BIOLOGY

GPR37 Surface Expression Enhancement via N-Terminal Truncation or Protein−Protein Interactions

(2009) Jill H. Dunham et al.   BIOCHEMISTRY

Central action of prosaptide TX14(A) against gp120-induced allodynia in rats

(2007) Corinne G. Jolivalt et al.   EUROPEAN JOURNAL OF PAIN