Metalloprotease cleavage of the N terminus of the orphan G protein–coupled receptor GPR37L1 reduces its constitutive activity

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1

(2015) Nicola J. Smith   Frontiers in Pharmacology

Basis for substrate recognition and distinction by matrix metalloproteinases

(2014) Boris I. Ratnikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Functional interactions between matrix metalloproteinases and glycosaminoglycans

(2013) Autumn Tocchi et al.   FEBS Journal

GPR37 Protein Trafficking to the Plasma Membrane Regulated by Prosaposin and GM1 Gangliosides Promotes Cell Viability

(2013) Ebba Gregorsson Lundius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor

(2013) D. Marazziti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

(2013) Rebecca C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

(2012) Xiao-long Tang et al.   ACTA PHARMACOLOGICA SINICA

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Roles of proteolysis in regulation of GPCR function

(2012) GS Cottrell   BRITISH JOURNAL OF PHARMACOLOGY

New concepts in pharmacological efficacy at 7TM receptors: IUPHAR Review 2

(2012) Terry Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR

(2012) Baran A Ersoy et al.   Nature Chemical Biology

Low Affinity GPCRs for Metabolic Intermediates: Challenges for Pharmacologists

(2012) Nicola J. Smith   Frontiers in Endocrinology

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

(2011) N. J. Smith et al.   MOLECULAR PHARMACOLOGY

Identification of genes related to heart failure using global gene expression profiling of human failing myocardium

(2010) Kyung-Duk Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13

(2010) Laura Jenkins et al.   BIOCHEMICAL JOURNAL

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of matrix metalloproteinase activity in health and disease

(2010) Elin Hadler-Olsen et al.   FEBS Journal

Human β1-Adrenergic Receptor Is Subject to Constitutive and Regulated N-terminal Cleavage

(2010) Anna E. Hakalahti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis

(2010) Flavia Giannone et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Establishing the Proteome of Normal Human Cerebrospinal Fluid

(2010) Steven E. Schutzer et al.   PLoS One

Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

(2010) Xuemei Zhao et al.   PROTEOMICS

GPR37 Surface Expression Enhancement via N-Terminal Truncation or Protein−Protein Interactions

(2009) Jill H. Dunham et al.   BIOCHEMISTRY

The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1

(2009) Nicola J. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α1b-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

(2008) Meritxell Canals et al.   BIOCHEMICAL JOURNAL

Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids

(2008) Leigh A. Stoddart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY