What is microglia neurotoxicity (Not)?

Effects of 56Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2)

(2013) Jacob Raber et al.   BEHAVIOURAL BRAIN RESEARCH

Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2

(2013) Patricia de Monasterio-Schrader et al.   GLIA

Unique transcriptome signature of mouse microglia

(2013) Clara Beutner et al.   GLIA

Microglial polarization and plasticity: Evidence from organotypic hippocampal slice cultures

(2013) Maria Antonietta Ajmone-Cat et al.   GLIA

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

(2013) Jessica M. Crain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain microglia: watchdogs with pedigree

(2013) Harald Neumann et al.   NATURE NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Phagocytosis executes delayed neuronal death after focal brain ischemia

(2013) J. J. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Microglia, seen from the CX3CR1 angle

(2013) Yochai Wolf et al.   Frontiers in Cellular Neuroscience

Polarization of macrophages and microglia in inflammatory demyelination

(2013) Li Cao et al.   Neuroscience Bulletin

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Altered Expression of CX3CL1 in Patients with Epilepsy and in a Rat Model

(2012) Yali Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus

(2012) Min-Hee Yi et al.   BRAIN RESEARCH

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Secreted protein lipocalin-2 promotes microglial M1 polarization

(2012) Eunha Jang et al.   FASEB JOURNAL

Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia

(2012) C Maiorino et al.   GENE THERAPY

Editors' preface: Microglia-A new era dawns

(2012) Richard M. Ransohoff et al.   GLIA

The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage

(2012) Yao Yao et al.   GLIA

Phenotyping primary human microglia: Tight regulation of LPS responsiveness

(2012) Jeroen Melief et al.   GLIA

Animal models for studying microglia: The first, the popular, and the new

(2012) Dirk Sieger et al.   GLIA

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

(2012) Jonathan Vinet et al.   Journal of Neuroinflammation

The Soluble Isoform of CX3CL1 Is Necessary for Neuroprotection in a Mouse Model of Parkinson's Disease

(2012) J. M. Morganti et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke

(2012) D. Fernández-López et al.   NEUROSCIENCE

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

(2012) N. H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Non-Identical Twins – Microglia and Monocyte-Derived Macrophages in Acute Injury and Autoimmune Inflammation

(2012) Steffen Jung et al.   Frontiers in Immunology

Genetic approaches to study glial cells in the rodent brain

(2011) Frank W. Pfrieger et al.   GLIA

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

(2011) Seo-Hyun Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood

(2011) M. Mizutani et al.   JOURNAL OF IMMUNOLOGY

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease

(2011) Mibel M Pabon et al.   Journal of Neuroinflammation

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents

(2011) R. Cipriani et al.   JOURNAL OF NEUROSCIENCE

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats

(2011) Tomas Drabek et al.   RESUSCITATION

Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity

(2010) Shannon Levesque et al.   BRAIN

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

(2010) Angela M. Wynne et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia dynamics and function in the CNS

(2010) Christopher N Parkhurst et al.   CURRENT OPINION IN NEUROBIOLOGY

Microglia in the CNS: Immigrants from another world

(2010) Marco Prinz et al.   GLIA

CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus

(2010) Hilmar R.J. van Weering et al.   HIPPOCAMPUS

Microglia in the aging brain: relevance to neurodegeneration

(2010) Xiao-Guang Luo et al.   Molecular Neurodegeneration

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

(2010) Joanna Mikita et al.   Multiple Sclerosis Journal

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice

(2010) Martine M. Mirrione et al.   NEUROBIOLOGY OF DISEASE

Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice

(2010) Sanae Hasegawa-Ishii et al.   NEUROPATHOLOGY

Adenosine A1 Receptors and Microglial Cells Mediate CX3CL1-Induced Protection of Hippocampal Neurons Against Glu-Induced Death

(2010) Clotilde Lauro et al.   NEUROPSYCHOPHARMACOLOGY

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

(2010) Hanneke L.D.M. Willemen et al.   PAIN

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Proteomic analysis of the anti-inflammatory action of minocycline

(2010) Christopher R. Dunston et al.   PROTEOMICS

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Senescent synapses and hippocampal circuit dynamics

(2010) Sara N. Burke et al.   TRENDS IN NEUROSCIENCES

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice

(2009) Cora H. Nijboer et al.   BRAIN BEHAVIOR AND IMMUNITY

Immunotoxic depletion of microglia in mouse hippocampal slice cultures enhances ischemia-like neurodegeneration

(2009) Maria Montero et al.   BRAIN RESEARCH

The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice

(2009) Matthias Schilling et al.   BRAIN RESEARCH

Neuroprotective effects of the anti-inflammatory compound triflusal on ischemia-like neurodegeneration in mouse hippocampal slice cultures occur independent of microglia

(2009) Maria Montero Domínguez et al.   EXPERIMENTAL NEUROLOGY

Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging

(2009) Sjef Copray et al.   GLIA

Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences

(2009) Jonathan P. Godbout et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Differential gene expression in LPS/IFNγ activated microglia and macrophages:in vitroversusin vivo

(2009) Christoph D. Schmid et al.   JOURNAL OF NEUROCHEMISTRY

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions

(2009) Nathalie Koning et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic Pain

(2009) H. Jung et al.   JOURNAL OF NEUROSCIENCE

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

(2009) V. Wee Yong et al.   NEURON

Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice

(2009) M. Schilling et al.   NEUROSCIENCE

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice

(2009) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death

(2008) Ik-Hyun Cho et al.   BRAIN

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Astroglia in dementia and Alzheimer's disease

(2008) J J Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

The value of incomplete mouse models of Alzheimer’s disease

(2008) Rebecca Radde et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

(2008) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Monocyte chemoattractant protein-1 (MCP-1) produced via NF-κB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats

(2008) Y. Y. Deng et al.   GLIA

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

(2008) Teresa F Pais et al.   Journal of Neuroinflammation

Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase

(2008) G. Gowing et al.   JOURNAL OF NEUROSCIENCE

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

(2008) S. Lehnardt et al.   JOURNAL OF NEUROSCIENCE

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

(2008) S. Jimenez et al.   JOURNAL OF NEUROSCIENCE