Genetic approaches to study glial cells in the rodent brain

Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine

(2011) Jonathan P. Wisor et al.   BRAIN BEHAVIOR AND IMMUNITY

Transmitter- and hormone-activated Ca2+ responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca2+ sensor

(2011) Stefanie Seifert et al.   CELL CALCIUM

Age-dependent fate and lineage restriction of single NG2 cells

(2011) X. Zhu et al.   DEVELOPMENT

Visualization and genetic manipulation of adult neurogenesis using transgenic mice

(2011) Jagroop Dhaliwal et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

New tools for the analysis of glial cell biology in Drosophila

(2011) Takeshi Awasaki et al.   GLIA

CNS live imaging reveals a new mechanism of myelination: The liquid croissant model

(2011) Bettina Sobottka et al.   GLIA

Genetic modeling of gliomas in mice: New tools to tackle old problems

(2011) Dolores Hambardzumyan et al.   GLIA

SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury

(2011) Vicki M Tysseling et al.   Journal of Neuroinflammation

Macroglial Plasticity and the Origins of Reactive Astroglia in Experimental Autoimmune Encephalomyelitis

(2011) F. Guo et al.   JOURNAL OF NEUROSCIENCE

Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage

(2011) H. B. F. Pohl et al.   JOURNAL OF NEUROSCIENCE

Pointing in the right direction: new developments in the field of planar cell polarity

(2011) Roy Bayly et al.   NATURE REVIEWS GENETICS

Lake-Front Property: A Unique Germinal Niche by the Lateral Ventricles of the Adult Brain

(2011) Rebecca A. Ihrie et al.   NEURON

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Ascl1 (Mash1) Defines Cells with Long-Term Neurogenic Potential in Subgranular and Subventricular Zones in Adult Mouse Brain

(2011) Euiseok J. Kim et al.   PLoS One

The Proteolipid Protein Promoter Drives Expression outside of the Oligodendrocyte Lineage during Embryonic and Early Postnatal Development

(2011) John-Paul Michalski et al.   PLoS One

TAL Effectors: Customizable Proteins for DNA Targeting

(2011) A. J. Bogdanove et al.   SCIENCE

Direct visualization of microtubules using a genetic tool to analyse radial progenitor-astrocyte continuum in brain

(2011) Tae-Yeon Eom et al.   Nature Communications

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Flexible Accelerated STOP Tetracycline Operator-Knockin (FAST): A Versatile and Efficient New Gene Modulating System

(2010) Kenji F. Tanaka et al.   BIOLOGICAL PSYCHIATRY

Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain

(2010) Beihui Liu et al.   BMC MOLECULAR BIOLOGY

A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination

(2010) Maria Traka et al.   BRAIN

NG2 cells: Properties, progeny and origin

(2010) Jacqueline Trotter et al.   BRAIN RESEARCH REVIEWS

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

(2010) Fanie Barnabé-Heider et al.   Cell Stem Cell

EphB Signaling Controls Lineage Plasticity of Adult Neural Stem Cell Niche Cells

(2010) Tadashi Nomura et al.   Cell Stem Cell

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II

(2010) Y. Hirota et al.   DEVELOPMENT

Role of astroglial connexin30 in hippocampal gap junction coupling

(2010) Dominic Gosejacob et al.   GLIA

Prospectively isolated CD133/CD24-positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long-term in vitro self-renewal and in vivo gene expression

(2010) Cosima V. Pfenninger et al.   GLIA

The Glia of Caenorhabditis elegans

(2010) Grigorios Oikonomou et al.   GLIA

Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice

(2010) Yongjie Yang et al.   GLIA

Microglia in the CNS: Immigrants from another world

(2010) Marco Prinz et al.   GLIA

Intrathecal Injection of Helper-Dependent Adenoviral Vectors Results in Long-Term Transgene Expression in Neuroependymal Cells and Neurons

(2010) Scott Dindot et al.   HUMAN GENE THERAPY

Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse

(2010) G. R. Wilson et al.   HUMAN MOLECULAR GENETICS

Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum

(2010) Ya-Jing Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Ways to Think about Cellular Internal Ribosome Entry

(2010) Wendy V. Gilbert   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche

(2010) C. R. Gajera et al.   JOURNAL OF CELL SCIENCE

Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

(2010) D. A. Hume   JOURNAL OF LEUKOCYTE BIOLOGY

The Fate of Synaptic Input to NG2 Glial Cells: Neurons Specifically Downregulate Transmitter Release onto Differentiating Oligodendroglial Cells

(2010) M. Kukley et al.   JOURNAL OF NEUROSCIENCE

Cilia Organize Ependymal Planar Polarity

(2010) Z. Mirzadeh et al.   JOURNAL OF NEUROSCIENCE

Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain

(2010) A. D. R. Garcia et al.   JOURNAL OF NEUROSCIENCE

Conditional RNAi in mice

(2010) Aljoscha Kleinhammer et al.   METHODS

Macrophage-mediated GDNF Delivery Protects Against Dopaminergic Neurodegeneration: A Therapeutic Strategy for Parkinson's Disease

(2010) KC Biju et al.   MOLECULAR THERAPY

AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice

(2010) James C Dodge et al.   MOLECULAR THERAPY

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia

(2010) Boris Guirao et al.   NATURE CELL BIOLOGY

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

(2010) Fadel Tissir et al.   NATURE NEUROSCIENCE

SOX9 induces and maintains neural stem cells

(2010) Charlotte E Scott et al.   NATURE NEUROSCIENCE

Rapid bacterial artificial chromosome modification for large-scale mouse transgenesis

(2010) Shiaoching Gong et al.   Nature Protocols

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Do astrocytes really exocytose neurotransmitters?

(2010) Nicola B. Hamilton et al.   NATURE REVIEWS NEUROSCIENCE

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Functions of Mature Mammalian Astrocytes: A Current View

(2010) Harold K. Kimelberg   NEUROSCIENTIST

Fluorescent Proteins and Their Applications in Imaging Living Cells and Tissues

(2010) Dmitriy M. Chudakov et al.   PHYSIOLOGICAL REVIEWS

Identification of Novel Glial Genes by Single-Cell Transcriptional Profiling of Bergmann Glial Cells from Mouse Cerebellum

(2010) Samir Koirala et al.   PLoS One

In vivo targeting of subventricular zone astrocytes

(2010) Carlyn Mamber et al.   PROGRESS IN NEUROBIOLOGY

Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca2+ Signaling

(2010) C. Agulhon et al.   SCIENCE

Specification and Morphogenesis of Astrocytes

(2010) M. R. Freeman   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain

(2010) Conrad Johanson et al.   TOXICOLOGIC PATHOLOGY

Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes

(2010) Shinsuke Shibata et al.   Molecular Brain

Choroid plexus: biology and pathology

(2009) Hartwig Wolburg et al.   ACTA NEUROPATHOLOGICA

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Ependymal cells: biology and pathology

(2009) Marc R. Del Bigio   ACTA NEUROPATHOLOGICA

The Low-Density Lipoprotein Receptor-Related Protein 1 Mediates Tissue-Type Plasminogen Activator-Induced Microglial Activation in the Ischemic Brain

(2009) Chen Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Heterogeneity in astrocyte morphology and physiology

(2009) Vitali Matyash et al.   BRAIN RESEARCH REVIEWS

FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain

(2009) B. V. Jacquet et al.   DEVELOPMENT

C-terminal tagging with eGFP yields new insights into expression of connexin45 but prevents rescue of embryonic lethal connexin45-deficient mice

(2009) Julia von Maltzahn et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Lentiviral vectors for gene transfer into the spinal cord glial cells

(2009) A Meunier et al.   GENE THERAPY

Tet system in the brain: Transgenic rats and lentiviral vectors approach

(2009) Witold Konopka et al.   GENESIS

Inducible site-specific recombination in neural stem/progenitor cells

(2009) Jian Chen et al.   GENESIS

Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX3CR1

(2009) Coral-Ann B. Lewis et al.   GLIA

Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis

(2009) Xiaofang Tang et al.   GLIA

Determinants of regional and local diversity within the astroglial lineage of the normal central nervous system

(2009) James A. Hewett   JOURNAL OF NEUROCHEMISTRY

Connexin32 Mutations Cause Loss of Function in Schwann Cells and Oligodendrocytes Leading to PNS and CNS Myelination Defects

(2009) I. Sargiannidou et al.   JOURNAL OF NEUROSCIENCE

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Transgenic mice expressing a cameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo

(2009) Stan D. Atkin et al.   JOURNAL OF NEUROSCIENCE METHODS

Myosin IXa Regulates Epithelial Differentiation and Its Deficiency Results in Hydrocephalus

(2009) Marouan Abouhamed et al.   MOLECULAR BIOLOGY OF THE CELL

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

(2009) Marie Carlén et al.   NATURE NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both?

(2009) Andrew K. Chojnacki et al.   NATURE REVIEWS NEUROSCIENCE

The ependymal route for insulin-like growth factor-1 gene therapy in the brain

(2009) C.B. Hereñú et al.   NEUROSCIENCE

Expression and localization of the Parkin Co-Regulated Gene in mouse CNS suggests a role in ependymal cilia function

(2009) Gabrielle R. Wilson et al.   NEUROSCIENCE LETTERS

Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo

(2009) Johannes Hirrlinger et al.   PLoS One

Silencing Inhibits Cre-Mediated Recombination of the Z/AP and Z/EG Reporters in Adult Cells

(2009) Michael A. Long et al.   PLoS One

A Novel Mouse Model Reveals that Polycystin-1 Deficiency in Ependyma and Choroid Plexus Results in Dysfunctional Cilia and Hydrocephalus

(2009) Claas Wodarczyk et al.   PLoS One

Astrocytes and the regulation of cerebral blood flow

(2009) Raymond C. Koehler et al.   TRENDS IN NEUROSCIENCES

Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1

(2008) Kakuri M. Omari et al.   AMERICAN JOURNAL OF PATHOLOGY

Viral vectors based on bidirectional cell-specific mammalian promoters and transcriptional amplification strategy for use in vitro and in vivo

(2008) Beihui Liu et al.   BMC BIOTECHNOLOGY

Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death

(2008) Ik-Hyun Cho et al.   BRAIN

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code

(2008) Christian Hochstim et al.   CELL

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

(2008) Joseph P. Doyle et al.   CELL

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

NG2-expressing cells in the nervous system revealed by the NG2-EYFP-knockin mouse

(2008) Khalad Karram et al.   GENESIS

A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system

(2008) Jill M. Weimer et al.   GLIA

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

Quality control of astrocyte-directed Cre transgenic mice: The benefits of a direct link between loss of gene expression and reporter activation

(2008) Robert Pascal Requardt et al.   GLIA

Engineered lentiviral vector targeting astrocytesIn vivo

(2008) Angélique Colin et al.   GLIA

Neuroblast proliferation on the surface of the adult rat striatal wall after focal ependymal loss by intracerebroventricular injection of neuraminidase

(2008) María Del Carmen Gómez-Roldán et al.   JOURNAL OF COMPARATIVE NEUROLOGY

CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain

(2008) Karen Bulloch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The transcriptome of retinal Müller glial cells

(2008) Karin Roesch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Ly6c+“inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

(2008) Daniel R. Getts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Separate Proteolipid Protein/DM20 Enhancers Serve Different Lineages and Stages of Development

(2008) M. C. Tuason et al.   JOURNAL OF NEUROSCIENCE

Early Neuronal and Glial Fate Restriction of Embryonic Neural Stem Cells

(2008) D. Delaunay et al.   JOURNAL OF NEUROSCIENCE

Subventricular Zone-Mediated Ependyma Repair in the Adult Mammalian Brain

(2008) J. Luo et al.   JOURNAL OF NEUROSCIENCE

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation

(2008) Fanie Barnabé-Heider et al.   NATURE METHODS

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

(2008) Akiko Nishiyama et al.   NATURE REVIEWS NEUROSCIENCE

Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development

(2008) Todd E Anthony et al.   Neural Development

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain

(2008) V. Coskun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells

(2008) Lionel M. L. Chow et al.   TRANSGENIC RESEARCH

Lack of connexin43-mediated Bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning

(2008) Mika Tanaka   Frontiers in Behavioral Neuroscience

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

(2008) Konstantinos Meletis et al.   PLOS BIOLOGY

Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping

(2007) M.A. Vogt et al.   EXPERIMENTAL NEUROLOGY