Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy

IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

(2013) Sheetal Bodhankar et al.   METABOLIC BRAIN DISEASE

CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia

(2013) Julian Zimmermann et al.   PLoS One

Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model

(2012) Zacharias Kohl et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

(2012) Kiren Ubhi et al.   EXPERIMENTAL NEUROLOGY

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1

(2012) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia

(2012) Shuwen Cao et al.   Journal of Neuroinflammation

Role of  -Synuclein in Adult Neurogenesis and Neuronal Maturation in the Dentate Gyrus

(2012) B. Winner et al.   JOURNAL OF NEUROSCIENCE

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

(2012) Carla M. Lema Tomé et al.   MOLECULAR NEUROBIOLOGY

Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease

(2012) Katrina L. Paumier et al.   MOVEMENT DISORDERS

Fluoxetine Promotes Remission in Acute Experimental Autoimmune Encephalomyelitis in Rats

(2012) Xi-qiu Yuan et al.   NEUROIMMUNOMODULATION

A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease

(2012) I. H. Richard et al.   NEUROLOGY

Neuronal to oligodendroglial alpha-synuclein redistribution in a double transgenic model of multiple system atrophy

(2012) Edward Rockenstein et al.   NEUROREPORT

Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

(2012) Guilherme A. Behr et al.   Oxidative Medicine and Cellular Longevity

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

(2012) Haya Kisos et al.   PLoS One

Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice

(2011) Seong-Joon Koh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Antidepressants encounter autophagy in neural cells

(2011) Jürgen Zschocke et al.   Autophagy

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

A study on the mechanisms involving the anti-inflammatory effect of amitriptyline in carrageenan-induced paw edema in rats

(2011) Hossein Sadeghi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease

(2011) Yong-Hwan Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Antidepressants and Neuroinflammation: Can Antidepressants Calm Glial Rage Down?

(2011) S. Hashioka   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

(2011) C Anacker et al.   MOLECULAR PSYCHIATRY

Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells

(2011) Dexiang Liu et al.   NEUROPHARMACOLOGY

Fluoxetine protects neurons against microglial activation-mediated neurotoxicity

(2011) Feng Zhang et al.   PARKINSONISM & RELATED DISORDERS

Amitriptyline-Mediated Cognitive Enhancement in Aged 3×Tg Alzheimer's Disease Mice Is Associated with Neurogenesis and Neurotrophic Activity

(2011) Wayne Chadwick et al.   PLoS One

Chemokines and Inflammatory Mediators Interact to Regulate Adult Murine Neural Precursor Cell Proliferation, Survival and Differentiation

(2011) Alisa Turbic et al.   PLoS One

Antidepressants Stimulate Hippocampal Neurogenesis by Inhibiting p21 Expression in the Subgranular Zone of the Hipppocampus

(2011) Robert N. Pechnick et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

(2011) Vahap Ozan Kotan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update

(2010) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

NF-κB Mediates IL-1β– and IL-17A–InducedMUC5BExpression in Airway Epithelial Cells

(2010) Tomoyuki Fujisawa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Interleukin-10 repletion suppresses pro-inflammatory cytokines and decreases liver pathology without altering viral replication in murine cytomegalovirus (MCMV)-infected IL-10 knockout mice

(2010) Yajarayma J. Tang-Feldman et al.   INFLAMMATION RESEARCH

The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma

(2010) Suzanne M. Cloonan et al.   INTERNATIONAL JOURNAL OF CANCER

Entacapone and Tolcapone, Two CatecholO-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity

(2010) Saviana Di Giovanni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluoxetine prevents stimulation-dependent fatigue of synaptic vesicle exocytosis in hippocampal neurons

(2010) Andreas Wolfram Henkel et al.   JOURNAL OF NEUROCHEMISTRY

Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors

(2010) K. Ubhi et al.   JOURNAL OF NEUROSCIENCE

Astrogliosis in CNS Pathologies: Is There A Role for Microglia?

(2010) Dan Zhang et al.   MOLECULAR NEUROBIOLOGY

Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease

(2010) Marwa Aboukhatwa et al.   Molecular Neurodegeneration

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

(2010) He-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Amitriptyline and Acute Inflammation: A Study Using Intravital Microscopy and the Carrageenan-Induced Paw Edema Model

(2010) L. Vismari et al.   PHARMACOLOGY

Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats

(2009) Yueh-Hua Tai et al.   ANESTHESIOLOGY

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus

(2009) Yinchuan Jin et al.   BRAIN RESEARCH

Interleukin-10 provides direct trophic support to neurons

(2009) Zhigang Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Imbalance between Pro- and Anti-inflammatory Cytokines, and between Th1 and Th2 Cytokines in Depressed Patients: The Effect of Electroacupuncture or Fluoxetine Treatment

(2009) C. Song et al.   PHARMACOPSYCHIATRY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments

(2008) Darrick T. Balu et al.   BRAIN RESEARCH

IFN-γ enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer’s disease

(2008) Rona Baron et al.   FASEB JOURNAL

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells

(2008) J.-W. Wang et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice

(2008) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect

(2008) Chae-Moon Lim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

A controlled trial of antidepressants in patients with Parkinson disease and depression

(2008) M. Menza et al.   NEUROLOGY

Second consensus statement on the diagnosis of multiple system atrophy

(2008) S. Gilman et al.   NEUROLOGY

Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice

(2008) Haruhiko Sugino et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production

(2007) Kazue Hisaoka et al.   BRAIN RESEARCH

Mutant α-synuclein exacerbates age-related decrease of neurogenesis

(2007) Beate Winner et al.   NEUROBIOLOGY OF AGING

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING

Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells

(2003) Kazue Hisaoka et al.   JOURNAL OF NEUROCHEMISTRY