Entacapone and Tolcapone, Two CatecholO-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity

COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson’s disease (PD): relevance for motor and non-motor features

(2011) Angelo Antonini   Neuropsychiatric Disease and Treatment

Tolcapone: review of its pharmacology and use as adjunctive therapy in patients with Parkinson's disease

(2010) Daniel Truong   Clinical Interventions in Aging

Structure and function of the molecular chaperone Hsp104 from yeast

(2009) Valerie Grimminger-Marquardt et al.   BIOPOLYMERS

New drug delivery strategies for improved Parkinson's disease therapy

(2009) Antonio Di Stefano et al.   Expert Opinion on Drug Delivery

α-Synuclein and neuronal cell death

(2009) Mark R Cookson   Molecular Neurodegeneration

Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

(2009) Ying Feng et al.   NEUROTOXICOLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective Properties of Gallic Acid from Sanguisorbae Radix on Amyloid β Protein (25—35)-Induced Toxicity in Cultured Rat Cortical Neurons

(2008) Ju Yeon Ban et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (−)-epigallocatechin gallate

(2008) Kosuke Dodo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Levodopa/DDCI and entacapone is the preferred treatment for Parkinson’s disease patients with motor fluctuations in routine practice: a retrospective, observational analysis of a large French cohort

(2008) P. Damier et al.   EUROPEAN JOURNAL OF NEUROLOGY

What’s in the pipeline for the treatment of Parkinson’s disease?

(2008) David B Sommer et al.   Expert Review of Neurotherapeutics

Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat

(2008) A Armagan et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

(2008) Christophe Lo Bianco et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

(2008) Mubeen Ahmad Ansari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation

(2008) Donggeun Sul et al.   LIFE SCIENCES

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

(2008) Fernando E. Herrera et al.   PLoS One

C-terminal peptides coassemble into A 42 oligomers and protect neurons against A 42-induced neurotoxicity

(2008) E. A. Fradinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex

(2008) C. C. Lapish et al.   PSYCHOPHARMACOLOGY

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING