Homing endonucleases: DNA scissors on a mission

Catalytic Activity Control of Restriction Endonuclease—Triplex Forming Oligonucleotide Conjugates

(2012) Arunas Silanskas et al.   BIOCONJUGATE CHEMISTRY

Recent advances in targeted genome engineering in mammalian systems

(2012) Ning Sun et al.   Biotechnology Journal

Molecular scissors forin situcellular repair

(2012) Jesús Prieto et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

(2012) Sarah Baxter et al.   NUCLEIC ACIDS RESEARCH

Chemical and biological approaches to improve the efficiency of homologous recombination in human cells mediated by artificial restriction DNA cutter

(2012) Hitoshi Katada et al.   NUCLEIC ACIDS RESEARCH

Structural, functional and evolutionary relationships between homing endonucleases and proteins from their host organisms

(2012) G. K. Taylor et al.   NUCLEIC ACIDS RESEARCH

Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space

(2012) Kyle Jacoby et al.   NUCLEIC ACIDS RESEARCH

LAHEDES: the LAGLIDADG homing endonuclease database and engineering server

(2012) G. K. Taylor et al.   NUCLEIC ACIDS RESEARCH

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

(2012) Erin L. Doyle et al.   NUCLEIC ACIDS RESEARCH

Monomeric site-specific nucleases for genome editing

(2012) B. P. Kleinstiver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural modeling of TAL effector-DNA interactions

(2012) Philip Bradley   PROTEIN SCIENCE

The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

(2012) A. N.-S. Mak et al.   SCIENCE

Infertility resulting from transgenic I-PpoI maleAnopheles gambiaein large cage trials

(2012) T A Klein et al.   Pathogens and Global Health

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Development of a Markerless Gene Replacement System for Acidithiobacillus ferrooxidans and Construction of apfkBMutant

(2011) Huiyan Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Homing endonucleases residing within inteins: evolutionary puzzles awaiting genetic solutions

(2011) Adi Barzel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Learning to live together: mutualism between self-splicing introns and their hosts

(2011) David R Edgell et al.   BMC BIOLOGY

GAL1-SceI directed site-specific genomic (gsSSG) mutagenesis: a method for precisely targeting point mutations in S. cerevisiae

(2011) Sarah Piccirillo et al.   BMC BIOTECHNOLOGY

Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

(2011) George Silva et al.   CURRENT GENE THERAPY

The highly variable mitochondrial small-subunit ribosomal RNA gene of Ophiostoma minus

(2011) Mohamed Hafez et al.   Fungal Biology

Insect Population Control by Homing Endonuclease-Based Gene Drive: An Evaluation inDrosophila melanogaster

(2011) Yuk-Sang Chan et al.   GENETICS

Genome Engineering With Zinc-Finger Nucleases

(2011) Dana Carroll   GENETICS

Gene therapy for primary immunodeficiencies: Looking ahead, toward gene correction

(2011) Itai M. Pessach et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

(2011) Nikolai Windbichler et al.   NATURE

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

(2011) Vikram Pattanayak et al.   NATURE METHODS

Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificity

(2011) S.-H. Chan et al.   NUCLEIC ACIDS RESEARCH

Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases

(2011) Ines Fonfara et al.   NUCLEIC ACIDS RESEARCH

Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family

(2011) Gregory K. Taylor et al.   NUCLEIC ACIDS RESEARCH

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Native homing endonucleases can target conserved genes in humans and in animal models

(2011) Adi Barzel et al.   NUCLEIC ACIDS RESEARCH

Novel reporter systems for facile evaluation of I-SceI-mediated genome editing

(2011) Nina M. Muñoz et al.   NUCLEIC ACIDS RESEARCH

Zinc Finger Nuclease and Homing Endonuclease-Mediated Assembly of Multigene Plant Transformation Vectors

(2011) V. Zeevi et al.   PLANT PHYSIOLOGY

Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI

(2011) Martine Aubert et al.   PLoS One

DNA Nicks Promote Efficient and Safe Targeted Gene Correction

(2011) Luther Davis et al.   PLoS One

Tapping natural reservoirs of homing endonucleases for targeted gene modification

(2011) Ryo Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirements for effective malaria control with homing endonuclease genes

(2011) A. Deredec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent insertion of 5'-terminal nucleotides and loss of the branchpoint motif in lineages of group II introns inserted in mitochondrial preribosomal RNAs

(2011) C.-F. Li et al.   RNA

Targeted Genome Editing Across Species Using ZFNs and TALENs

(2011) Andrew J. Wood et al.   SCIENCE

TAL Effectors: Customizable Proteins for DNA Targeting

(2011) A. J. Bogdanove et al.   SCIENCE

Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

(2011) Barry L. Stoddard   STRUCTURE

Permanent genome modifications in plant cells by transient viral vectors

(2011) Alexander Vainstein et al.   TRENDS IN BIOTECHNOLOGY

XanthomonasAvrBs3 Family-Type III Effectors: Discovery and Function

(2010) Jens Boch et al.   Annual Review of Phytopathology

I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomycetes

(2010) Theresa Siegl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template

(2010) Michael J. Metzger et al.   NUCLEIC ACIDS RESEARCH

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

(2010) Justin Ashworth et al.   NUCLEIC ACIDS RESEARCH

Targeted genome engineering via zinc finger nucleases

(2010) Seokjoong Kim et al.   Plant Biotechnology Reports

The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy

(2010) S. Arnould et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation

(2010) Aaron Klug   QUARTERLY REVIEWS OF BIOPHYSICS

A group II intron encodes a functional LAGLIDADG homing endonuclease and self-splices under moderate temperature and ionic conditions

(2010) S.-T. Mullineux et al.   RNA

Mobile DNA elements in T4 and related phages

(2010) David R Edgell et al.   Virology Journal

TAL effector-DNA specificity

(2010) Heidi Scholze et al.   Virulence

Modern approaches for the biological control of vertebrate pests: An Australian perspective

(2009) Glen Saunders et al.   BIOLOGICAL CONTROL

Homing endonucleases: from basics to therapeutic applications

(2009) Maria J. Marcaida et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Likely Pathway for Formation of Mobile Group I Introns

(2009) Richard P. Bonocora et al.   CURRENT BIOLOGY

A Free-Standing Homing Endonuclease Targets an Intron Insertion Site in the psbA Gene of Cyanophages

(2009) Qinglu Zeng et al.   CURRENT BIOLOGY

Homing endonucleases catalyze double-stranded DNA breaks and somatic transgene excision inAedes aegypti

(2009) B. E. Traver et al.   INSECT MOLECULAR BIOLOGY

Genes within Genes: Multiple LAGLIDADG Homing Endonucleases Target the Ribosomal Protein S3 Gene Encoded within an rnl Group I Intron of Ophiostoma and Related Taxa

(2009) J. Sethuraman et al.   MOLECULAR BIOLOGY AND EVOLUTION

Exploitation of binding energy for catalysis and design

(2009) Summer B. Thyme et al.   NATURE

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

(2009) Vipula K. Shukla et al.   NATURE

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

(2009) Hui Li et al.   NUCLEIC ACIDS RESEARCH

Creation of a type IIS restriction endonuclease with a long recognition sequence

(2009) Shaun M. Lippow et al.   NUCLEIC ACIDS RESEARCH

Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family

(2009) Bareket Dassa et al.   NUCLEIC ACIDS RESEARCH

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

(2009) Jordan Jarjour et al.   NUCLEIC ACIDS RESEARCH

Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

REBASE—a database for DNA restriction and modification: enzymes, genes and genomes

(2009) Richard J. Roberts et al.   NUCLEIC ACIDS RESEARCH

Heritable targeted mutagenesis in maize using a designed endonuclease

(2009) Huirong Gao et al.   PLANT JOURNAL

Targeted mutagenesis in the progeny of maize transgenic plants

(2009) Meizhu Yang et al.   PLANT MOLECULAR BIOLOGY

Linear group II intron RNAs can retrohome in eukaryotes and may use nonhomologous end-joining for cDNA ligation

(2009) F. Zhuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

(2009) A. McConnell Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting

(2009) F. Zhuang et al.   RNA

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

The ribozyme core of group II introns: a structure in want of partners

(2009) François Michel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy

(2009) Utpal P. Davé et al.   PLoS Genetics

A system for the construction of targeted unmarked gene deletions in the genus Burkholderia

(2008) Ronald S. Flannagan et al.   ENVIRONMENTAL MICROBIOLOGY

The Population Genetics of Using Homing Endonuclease Genes in Vector and Pest Management

(2008) A. Deredec et al.   GENETICS

Engineering Variants of the I-SceI Homing Endonuclease with Strand-specific and Site-specific DNA-nicking Activity

(2008) Yan Niu et al.   JOURNAL OF MOLECULAR BIOLOGY

Activity and Specificity of the Bacterial PD-(D/E)XK Homing Endonuclease I-Ssp6803I

(2008) Lei Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY

Zinc-finger Nucleases: The Next Generation Emerges

(2008) Toni Cathomen et al.   MOLECULAR THERAPY

Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

(2008) Pilar Redondo et al.   NATURE

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

(2008) L. Glover et al.   NUCLEIC ACIDS RESEARCH

Group II Intron-Based Gene Targeting Reactions in Eukaryotes

(2008) Marta Mastroianni et al.   PLoS One

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

(2008) Y. Santiago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future biological control of pest populations of European rabbits,Oryctolagus cuniculus

(2008) Robert P. Henzell et al.   WILDLIFE RESEARCH

Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae

(2008) Nikolai Windbichler et al.   PLoS Genetics