The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy

Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAs

(2010) Thomas J Cradick et al.   MOLECULAR THERAPY

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

(2010) Stefan Stein et al.   NATURE MEDICINE

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

(2010) Justin Ashworth et al.   NUCLEIC ACIDS RESEARCH

IDENTIFICATION OF CONSERVED FEATURES OF LAGLIDADG HOMING ENDONUCLEASES

(2010) ALEXANDER GRISHIN et al.   Journal of Bioinformatics and Computational Biology

Targeted gene modifications in drug discovery and development

(2009) Jean-Pierre Cabaniols et al.   CURRENT OPINION IN PHARMACOLOGY

Targeted approaches for gene therapy and the emergence of engineered meganucleases

(2009) Roman Galetto et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

(2009) Hui Li et al.   NUCLEIC ACIDS RESEARCH

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

Heritable targeted mutagenesis in maize using a designed endonuclease

(2009) Huirong Gao et al.   PLANT JOURNAL

Targeted mutagenesis in the progeny of maize transgenic plants

(2009) Meizhu Yang et al.   PLANT MOLECULAR BIOLOGY

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

(2009) A. McConnell Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directed evolution of homing endonuclease I-SceI with altered sequence specificity

(2009) Z. Chen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Progress and prospects: Zinc-finger nucleases as gene therapy agents

(2008) D Carroll   GENE THERAPY

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

(2008) Steven J. Howe et al.   JOURNAL OF CLINICAL INVESTIGATION

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering Variants of the I-SceI Homing Endonuclease with Strand-specific and Site-specific DNA-nicking Activity

(2008) Yan Niu et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

(2008) Pilar Redondo et al.   NATURE

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

(2008) Emmanuel Fajardo-Sanchez et al.   NUCLEIC ACIDS RESEARCH

Rapid and efficient construction of markerless deletions in the Escherichia coli genome

(2008) B. J. Yu et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering

(2008) M. J. Marcaida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA