Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

Exploitation of binding energy for catalysis and design

(2009) Summer B. Thyme et al.   NATURE

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

(2009) Hui Li et al.   NUCLEIC ACIDS RESEARCH

Assessment of the optimization of affinity and specificity at protein–DNA interfaces

(2009) Justin Ashworth et al.   NUCLEIC ACIDS RESEARCH

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

(2009) Sylvestre Grizot et al.   NUCLEIC ACIDS RESEARCH

Heritable targeted mutagenesis in maize using a designed endonuclease

(2009) Huirong Gao et al.   PLANT JOURNAL

Directed evolution of homing endonuclease I-SceI with altered sequence specificity

(2009) Z. Chen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

(2008) Pilar Redondo et al.   NATURE